Toshiro Hara, PhD

Toshi received his B.S. from Osaka University, Japan, and his Ph.D. in Life Sciences from the University of Tokyo for studies on the metabolic regulation of macrophages with Dr. Motoharu Seiki at the Institute of Medical Science, the University of Tokyo. He was trained as a molecular biologist. He then joined the laboratory of Dr. Inder Verma, later of Dr. Tony Hunter, at the Salk Institute for Biological Studies, La Jolla. He initiated his postdoctoral work on intratumoral heterogeneity in glioblastoma by combining a mouse model of glioma with lineage tracing approaches, including lentiviral barcoding for single-cell RNA-seq in collaboration with Dr. Aviv Regev at the Broad Institute of MIT and Harvard. In 2019, he then, as a research fellow, joined Dr. Mario Suva’s laboratory in the Department of Pathology at Massachusetts General Hospital (MGH) and Harvard Medical School (HMS), and the Broad Institute. His postdoctoral studies delineated cellular states and plasticity in human glioblastoma and uncovered their molecular and cellular determinants. Working with clinical fellows and computational scientists, Toshi identified the joy of collaboration and the power of diverse perspectives in a team.

Measuring molecular and cellular heterogeneity in human cancers using genomics platforms. Integrating genetic and genomics tools into cell and animal model systems to study human cancers. Dissecting and engineering cell-to-cell interactions of brain tumor ecosystems