Elinor Levine Professor of Dementia Research and Professor of Neurology
Medical School
[email protected]
Available to mentor
Catherine C Kaczorowski, BA, PhD
Professor
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FellowshipMedical College of Wisconsin, Neuroproteomics of Alzheimer's, Kern Innovation Fellow, 2012
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FellowshipUniversity of Wisconsin–Milwaukee, Psychology, Cognitive Aging, 2009
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PhDNorthwestern University - Institue for Neuroscience, 2006
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BAUniversity of Wisconsin–Milwaukee, 2000
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N/AFront Range Community College, 1997
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Center MemberCenter for Computational Medicine and Bioinformatics
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Center MemberPrecision Health Initiative
My laboratory pioneers techniques to identify and validate genetic and cellular mechanisms that promote resilience to cognitive aging, Alzheimer's disease, and other age-related dementias. By combining mouse and human systems; genomic, anatomic, and behavioral approaches; and integrative analyses across multiple scales, data types, environmental factors, and species, we are accelerating discovery of the precise genetic mechanisms of cognitive resilience that could yield the next generation of targets and therapeutic strategies for promoting brain health. We are now uniquely poised to propel the field of personalized medicine forward using our genetically diverse, yet reproducible models of human neurodegenerative dementias, having already contributed conceptual and technical advances that revolutionized our ability to study complex diseases, specifically human AD dementia.
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Nackenoff AG, Hohman TJ, Neuner SM, Akers CS, Weitzel NC, Shostak A, Ferguson SM, Mobley B, Bennett DA, Schneider JA, Jefferson AL, Kaczorowski CC, Schrag MS. PLoS Genet, 2021 Apr; 17 (4): e1009406Proceeding / Abstract / PosterPLD3 is a neuronal lysosomal phospholipase D associated with β-amyloid plaques and cognitive function in Alzheimer's disease.
DOI:10.1371/journal.pgen.1009406 PMID: PMC8031396 -
Wan Y-W, Al-Ouran R, Mangleburg CG, Perumal TM, Lee TV, Allison K, Swarup V, Funk CC, Gaiteri C, Allen M, Wang M, Neuner SM, Kaczorowski CC, Philip VM, Howell GR, Martini-Stoica H, Zheng H, Mei H, Zhong X, Kim JW, Dawson VL, Dawson TM, Pao P-C, Tsai L-H, Haure-Mirande J-V, Ehrlich ME, Chakrabarty P, Levites Y, Wang X, Dammer EB, Srivastava G, Mukherjee S, Sieberts SK, Omberg L, Dang KD, Eddy JA, Snyder P, Chae Y, Amberkar S, Wei W, Hide W, Preuss C, Ergun A, Ebert PJ, Airey DC, Mostafavi S, Yu L, Klein H-U, Accelerating Medicines Partnership-Alzheimer’s Disease Consortium , Carter GW, Collier DA, Golde TE, Levey AI, Bennett DA, Estrada K, Townsend TM, Zhang B, Schadt E, De Jager PL, Price ND, Ertekin-Taner N, Liu Z, Shulman JM, Mangravite LM, Logsdon BA. Cell Rep, 2020 Jul 14; 32 (2): 107908Journal ArticleMeta-Analysis of the Alzheimer's Disease Human Brain Transcriptome and Functional Dissection in Mouse Models.
DOI:10.1016/j.celrep.2020.107908 PMID: PMC7428328 -
Wan Y-W, Al-Ouran R, Mangleburg CG, Lee TV, Allison K, Neuner S, Kaczorowski C, Phillip V, Howell G, Martini-Stoica H, Zheng H, Kim JW, Dawson V, Dawson T, Pao P-C, Tsai L-H, Haure-Mirande J-V, Wang M, Ehrlich ME, Mei H, Zhong X, Chakrabarty P, Levites Y, Golde TE, Levey AI, Consortium AMP-AD, Logsdon B, Mangravite L, Liu Z, Shulman JM. 2019 Jan 6; bioRxiv,PreprintFunctional dissection of Alzheimer’s disease brain gene expression signatures in humans and mouse models
DOI:10.1101/506873 -
Dunn AR, Kaur H, Dai M, Charland K, Ouellette AR, Hadad N, Doyle PH, Acosta GHG, Litkowski E, Hohman TJ, O’Connell KMS, Kaczorowski CC. 2025 Feb 11; bioRxiv,PreprintA genetically-diverse mouse model reveals a complex gene-environment regulation of cognitive resilience and susceptibility to Alzheimer’s disease
DOI:10.1101/2025.02.07.637137 -
Johnson GA, Tian Y, Hornburg K, Cook JJ, Qi Y, White LE, Killmar JT, Kaczorowski C, Ashbrook DG, Williams RW. 2025 Jan 12; bioRxiv,PreprintGlobal dissection of the impact of Alzheimer’s disease on brain architecture and behavior: High resolution MRH resolves robust regional effects
DOI:10.1101/2025.01.08.632011 -
Miller RA, Harrison DE, Cortopassi GA, Dehghan I, Fernandez E, Garratt M, Geisler JG, Ginsburg BC, Han ML, Kaczorowski CC, Kumar N, Leiser SF, Lopez‑Cruzan M, Milne G, Mitchell JR, Nelson JF, Reifsnyder PC, Salmon AB, Korstanje R, Rosenthal N, Strong R. Geroscience, 2025 Jan 1;Journal ArticleCorrection to: Lifespan effects in male UM-HET3 mice treated with sodium thiosulfate, 16-hydroxyestriol, and late-start canagliflozin (GeroScience, (2024), 46, 5, (4657-4670), 10.1007/s11357-024-01176-2)
DOI:10.1007/s11357-025-01752-0 -
Snyder JM, Harrison DE, Korstanje R, Ginsburg B, Reifsnyder PC, Nelson J, Leiser S, Kaczorowski C, Imai DM, Salmon AB, Strong R, Ladiges W, Miller RA. Geroscience, 2025 Jan 1;Journal ArticleEnd-of-life pathology in UM-HET3 mice treated with 16 α‑hydroxyestradiol or late‑start canagliflozin
DOI:10.1007/s11357-025-01741-3 -
Branch AE, McQuail J, Kaczorowski CC, Foster TC, Disterhoft JF, Huentelman MJ, Rapp PR, Barnes CA. Alzheimers Dement, 2024 Dec; 20 (Suppl 7):Journal ArticleA shared behavioral framework for assessing preserved cognitive function in aging in rodent models.
DOI:10.1002/alz.087235 PMID: PMC11716830
Department News
A man was identified with a rare mutation that protects from Alzheimer’s Disease.
