Catherine C Kaczorowski, BA, PhD
Elinor Levine Professor of Dementia Research and Professor of Neurology
[email protected]

Available to mentor
Catherine C Kaczorowski, BA, PhD
Professor
  • Qualifications
  • Center Memberships
  • Research Overview
  • Recent Publications
    • Qualifications
    • Fellowship
      Medical College of Wisconsin, Neuroproteomics of Alzheimer's, Kern Innovation Fellow, 2012
    • Fellowship
      University of Wisconsin–Milwaukee, Psychology, Cognitive Aging, 2009
    • PhD
      Northwestern University - Institue for Neuroscience, Evanston, IL, 2006
    • BA
      University of Wisconsin–Milwaukee, Milwaukee, WI, 2000
    • N/A
      Front Range Community College, Westminster, CO, 1997
    Center Memberships
    • Center Member
      Center for Computational Medicine and Bioinformatics
    • Center Member
      Precision Health Initiative
    Research Overview

    My laboratory pioneers techniques to identify and validate genetic and cellular mechanisms that promote resilience to cognitive aging, Alzheimer's disease, and other age-related dementias. By combining mouse and human systems; genomic, anatomic, and behavioral approaches; and integrative analyses across multiple scales, data types, environmental factors, and species, we are accelerating discovery of the precise genetic mechanisms of cognitive resilience that could yield the next generation of targets and therapeutic strategies for promoting brain health. We are now uniquely poised to propel the field of personalized medicine forward using our genetically diverse, yet reproducible models of human neurodegenerative dementias, having already contributed conceptual and technical advances that revolutionized our ability to study complex diseases, specifically human AD dementia.

    Recent Publications See All Publications
    • Proceeding / Abstract / Poster
      PLD3 is a neuronal lysosomal phospholipase D associated with β-amyloid plaques and cognitive function in Alzheimer's disease.
      Nackenoff AG, Hohman TJ, Neuner SM, Akers CS, Weitzel NC, Shostak A, Ferguson SM, Mobley B, Bennett DA, Schneider JA, Jefferson AL, Kaczorowski CC, Schrag MS. PLoS Genet, 2021 Apr; 17 (4): e1009406 DOI:10.1371/journal.pgen.1009406
      PMID: 33830999
    • Journal Article
      Meta-Analysis of the Alzheimer's Disease Human Brain Transcriptome and Functional Dissection in Mouse Models.
      Wan Y-W, Al-Ouran R, Mangleburg CG, Perumal TM, Lee TV, Allison K, Swarup V, Funk CC, Gaiteri C, Allen M, Wang M, Neuner SM, Kaczorowski CC, Philip VM, Howell GR, Martini-Stoica H, Zheng H, Mei H, Zhong X, Kim JW, Dawson VL, Dawson TM, Pao P-C, Tsai L-H, Haure-Mirande J-V, Ehrlich ME, Chakrabarty P, Levites Y, Wang X, Dammer EB, Srivastava G, Mukherjee S, Sieberts SK, Omberg L, Dang KD, Eddy JA, Snyder P, Chae Y, Amberkar S, Wei W, Hide W, Preuss C, Ergun A, Ebert PJ, Airey DC, Mostafavi S, Yu L, Klein H-U, Accelerating Medicines Partnership-Alzheimer’s Disease Consortium , Carter GW, Collier DA, Golde TE, Levey AI, Bennett DA, Estrada K, Townsend TM, Zhang B, Schadt E, De Jager PL, Price ND, Ertekin-Taner N, Liu Z, Shulman JM, Mangravite LM, Logsdon BA. Cell Rep, 2020 Jul 14; 32 (2): 107908 DOI:10.1016/j.celrep.2020.107908
      PMID: 32668255
    • Preprint
      Functional dissection of Alzheimer’s disease brain gene expression signatures in humans and mouse models
      Wan Y-W, Al-Ouran R, Mangleburg CG, Lee TV, Allison K, Neuner S, Kaczorowski C, Phillip V, Howell G, Martini-Stoica H, Zheng H, Kim JW, Dawson V, Dawson T, Pao P-C, Tsai L-H, Haure-Mirande J-V, Wang M, Ehrlich ME, Mei H, Zhong X, Chakrabarty P, Levites Y, Golde TE, Levey AI, Consortium AMP-AD, Logsdon B, Mangravite L, Liu Z, Shulman JM. bioRxiv, DOI:10.1101/506873
    • Journal Article
      Detecting the effect of genetic diversity on brain composition in an Alzheimer's disease mouse model.
      Gurdon B, Yates SC, Csucs G, Groeneboom NE, Hadad N, Telpoukhovskaia M, Ouellette A, Ouellette T, O'Connell KMS, Singh S, Murdy TJ, Merchant E, Bjerke I, Kleven H, Schlegel U, Leergaard TB, Puchades MA, Bjaalie JG, Kaczorowski CC. Commun Biol, 2024 May 20; 7 (1): 605 DOI:10.1038/s42003-024-06242-1
      PMID: 38769398
    • Preprint
      The Pgb1 locus controls glycogen aggregation in astrocytes of the aged hippocampus without impacting cognitive function.
      Gómez-Pascual A, Glikman DM, Ng HX, Tomkins JE, Lu L, Xu Y, Ashbrook DG, Kaczorowski C, Kempermann G, Killmar J, Mozhui K, Ohlenschläger O, Aebersold R, Ingram DK, Williams EG, Williams RW, Overall RW, Jucker M, de Bakker DEM. 2024 Jul 8; DOI:10.1101/2023.11.22.567373
      PMID: 38045339
    • Presentation
      Vanderbilt University Presentation
      Kaczorowski C. 2024 Apr 10;
    • Journal Article
      Genetic diversity promotes resilience in a mouse model of Alzheimer's disease.
      Soni N, Hohsfield LA, Tran KM, Kawauchi S, Walker A, Javonillo D, Phan J, Matheos D, Da Cunha C, Uyar A, Milinkeviciute G, Gomez-Arboledas A, Tran K, Kaczorowski CC, Wood MA, Tenner AJ, LaFerla FM, Carter GW, Mortazavi A, Swarup V, MacGregor GR, Green KN. Alzheimers Dement, 2024 Apr; 20 (4): 2794 - 2816. DOI:10.1002/alz.13753
      PMID: 38426371
    • Presentation
      Using Complex Genetics in Mice to Unlock the Secrets of Resilience to Dementia
      Kaczorowski C. 2024 Mar 15;
    Featured News & Stories
    Department News
    ScienceAlert: Man identified with rare mutation that protects from Alzheimer’s Disease
    A man was identified with a rare mutation that protects from Alzheimer’s Disease.