Elinor Levine Professor of Dementia Research and Professor of Neurology
[email protected]
Available to mentor
Catherine C Kaczorowski, BA, PhD
Professor
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FellowshipMedical College of Wisconsin, Neuroproteomics of Alzheimer's, Kern Innovation Fellow, 2012
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FellowshipUniversity of Wisconsin–Milwaukee, Psychology, Cognitive Aging, 2009
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PhDNorthwestern University - Institue for Neuroscience, Evanston, IL, 2006
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BAUniversity of Wisconsin–Milwaukee, Milwaukee, WI, 2000
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N/AFront Range Community College, Westminster, CO, 1997
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Center MemberCenter for Computational Medicine and Bioinformatics
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Center MemberPrecision Health Initiative
My laboratory pioneers techniques to identify and validate genetic and cellular mechanisms that promote resilience to cognitive aging, Alzheimer's disease, and other age-related dementias. By combining mouse and human systems; genomic, anatomic, and behavioral approaches; and integrative analyses across multiple scales, data types, environmental factors, and species, we are accelerating discovery of the precise genetic mechanisms of cognitive resilience that could yield the next generation of targets and therapeutic strategies for promoting brain health. We are now uniquely poised to propel the field of personalized medicine forward using our genetically diverse, yet reproducible models of human neurodegenerative dementias, having already contributed conceptual and technical advances that revolutionized our ability to study complex diseases, specifically human AD dementia.
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Nackenoff AG, Hohman TJ, Neuner SM, Akers CS, Weitzel NC, Shostak A, Ferguson SM, Mobley B, Bennett DA, Schneider JA, Jefferson AL, Kaczorowski CC, Schrag MS. PLoS Genet, 2021 Apr; 17 (4): e1009406Proceeding / Abstract / PosterPLD3 is a neuronal lysosomal phospholipase D associated with β-amyloid plaques and cognitive function in Alzheimer's disease.
DOI:10.1371/journal.pgen.1009406 PMID: 33830999 -
Wan Y-W, Al-Ouran R, Mangleburg CG, Perumal TM, Lee TV, Allison K, Swarup V, Funk CC, Gaiteri C, Allen M, Wang M, Neuner SM, Kaczorowski CC, Philip VM, Howell GR, Martini-Stoica H, Zheng H, Mei H, Zhong X, Kim JW, Dawson VL, Dawson TM, Pao P-C, Tsai L-H, Haure-Mirande J-V, Ehrlich ME, Chakrabarty P, Levites Y, Wang X, Dammer EB, Srivastava G, Mukherjee S, Sieberts SK, Omberg L, Dang KD, Eddy JA, Snyder P, Chae Y, Amberkar S, Wei W, Hide W, Preuss C, Ergun A, Ebert PJ, Airey DC, Mostafavi S, Yu L, Klein H-U, Accelerating Medicines Partnership-Alzheimer’s Disease Consortium , Carter GW, Collier DA, Golde TE, Levey AI, Bennett DA, Estrada K, Townsend TM, Zhang B, Schadt E, De Jager PL, Price ND, Ertekin-Taner N, Liu Z, Shulman JM, Mangravite LM, Logsdon BA. Cell Rep, 2020 Jul 14; 32 (2): 107908Journal ArticleMeta-Analysis of the Alzheimer's Disease Human Brain Transcriptome and Functional Dissection in Mouse Models.
DOI:10.1016/j.celrep.2020.107908 PMID: 32668255 -
Wan Y-W, Al-Ouran R, Mangleburg CG, Lee TV, Allison K, Neuner S, Kaczorowski C, Phillip V, Howell G, Martini-Stoica H, Zheng H, Kim JW, Dawson V, Dawson T, Pao P-C, Tsai L-H, Haure-Mirande J-V, Wang M, Ehrlich ME, Mei H, Zhong X, Chakrabarty P, Levites Y, Golde TE, Levey AI, Consortium AMP-AD, Logsdon B, Mangravite L, Liu Z, Shulman JM. bioRxiv,PreprintFunctional dissection of Alzheimer’s disease brain gene expression signatures in humans and mouse models
DOI:10.1101/506873 -
Gurdon B, Yates SC, Csucs G, Groeneboom NE, Hadad N, Telpoukhovskaia M, Ouellette A, Ouellette T, O'Connell KMS, Singh S, Murdy TJ, Merchant E, Bjerke I, Kleven H, Schlegel U, Leergaard TB, Puchades MA, Bjaalie JG, Kaczorowski CC. Commun Biol, 2024 May 20; 7 (1): 605Journal ArticleDetecting the effect of genetic diversity on brain composition in an Alzheimer's disease mouse model.
DOI:10.1038/s42003-024-06242-1 PMID: 38769398 -
Kaczorowski C. 2024 Apr 10;PresentationVanderbilt University Presentation
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Soni N, Hohsfield LA, Tran KM, Kawauchi S, Walker A, Javonillo D, Phan J, Matheos D, Da Cunha C, Uyar A, Milinkeviciute G, Gomez-Arboledas A, Tran K, Kaczorowski CC, Wood MA, Tenner AJ, LaFerla FM, Carter GW, Mortazavi A, Swarup V, MacGregor GR, Green KN. Alzheimers Dement, 2024 Apr; 20 (4): 2794 - 2816.Journal ArticleGenetic diversity promotes resilience in a mouse model of Alzheimer's disease.
DOI:10.1002/alz.13753 PMID: 38426371 -
Kaczorowski C. 2024 Mar 15;PresentationUsing Complex Genetics in Mice to Unlock the Secrets of Resilience to Dementia
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Kaczorowski C. 2024 Mar 13;PresentationUC Irvine Presentation
Department News
A man was identified with a rare mutation that protects from Alzheimer’s Disease.
