Assistant Professor of Ophthalmology and Visual Sciences
Assistant Professor of Cell and Developmental Biology
[email protected]
Available to mentor
Thanh Hoang, PhD
Assistant Professor
The central nervous system (CNS) is a highly complex structure composed of diverse subtypes of neurons and glia. Neurons in the retina, like elsewhere in the CNS, are highly susceptible to diseases, and their loss often result in blindness. Our research focuses on studying cell type specification during neural development and regeneration of lost neurons via cell fate reprogramming as a potential therapy for neurodegenerative diseases. Using a combination of multiomic and genetic tools, We are particularly interested in exploring the regenerative capacity and neuroprotective roles of glial cells: retinal Müller glia and astrocytes, in injury and neurodegenerative disorders.https://hoanglabregen.com/
Hoang Lab
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Leinonen H, Zhang J, Occelli LM, Seemab U, Choi EH, L P Marinho LF, Querubin J, Kolesnikov AV, Galinska A, Kordecka K, Hoang T, Lewandowski D, Lee TT, Einstein EE, Einstein DE, Dong Z, Kiser PD, Blackshaw S, Kefalov VJ, Tabaka M, Foik A, Petersen-Jones SM, Palczewski K. Nat Commun, 2024 Jul 15; 15 (1): 5943Journal ArticleA combination treatment based on drug repurposing demonstrates mutation-agnostic efficacy in pre-clinical retinopathy models.
DOI:10.1038/s41467-024-50033-5 PMID: 39009597 -
Emmerich K, Hageter J, Hoang T, Lyu P, Sharrock AV, Ceisel A, Thierer J, Chunawala Z, Nimmagadda S, Palazzo I, Matthews F, Zhang L, White DT, Rodriguez C, Graziano G, Marcos P, May A, Mulligan T, Reibman B, Saxena MT, Ackerley DF, Qian J, Blackshaw S, Horstick E, Mumm JS. Development, 2024 Aug 1; 151 (15):Journal ArticleA large-scale CRISPR screen reveals context-specific genetic regulation of retinal ganglion cell regeneration.
DOI:10.1242/dev.202754 PMID: 39007397 -
Le N, Vu T-D, Palazzo I, Pulya R, Kim Y, Blackshaw S, Hoang T. Sci Adv, 2024 Jul 12; 10 (28): eadn2091Journal ArticleRobust reprogramming of glia into neurons by inhibition of Notch signaling and nuclear factor I (NFI) factors in adult mammalian retina.
DOI:10.1126/sciadv.adn2091 PMID: 38996013 -
Upreti A, Hoang TV, Li M, Tangeman JA, Dierker DS, Wagner BD, Tsonis PA, Liang C, Lachke SA, Robinson ML. Invest Ophthalmol Vis Sci, 2024 Apr 1; 65 (4): 42Journal ArticlemiR-26 Deficiency Causes Alterations in Lens Transcriptome and Results in Adult-Onset Cataract.
DOI:10.1167/iovs.65.4.42 PMID: 38683565 -
Lyu P, Iribarne M, Serjanov D, Zhai Y, Hoang T, Campbell LJ, Boyd P, Palazzo I, Nagashima M, Silva NJ, Hitchcock PF, Qian J, Hyde DR, Blackshaw S. Nat Commun, 2023 Dec 20; 14 (1): 8477Journal ArticleCommon and divergent gene regulatory networks control injury-induced and developmental neurogenesis in zebrafish retina.
DOI:10.1038/s41467-023-44142-w PMID: 38123561 -
Emmerich K, Hageter J, Hoang T, Lyu P, Sharrock AV, Ceisel A, Thierer J, Chunawala Z, Nimmagadda S, Palazzo I, Matthews F, Zhang L, White DT, Rodriquez C, Graziano G, Marcos P, May A, Mulligan T, Reibman B, Saxena MT, Ackerley DF, Qian J, Blackshaw S, Horstick E, Mumm JS. 2023 Nov 21;PreprintMolecular regulation of retinal regeneration is context specific.
DOI:10.1101/2023.11.20.567904 PMID: 38045256 -
Blackshaw S, Lyu P, Zhai Y, Qian J, Iribarne M, Serjanov D, Campbell L, Boyd P, Hyde D, Palazzo I, Hoang T, Nagashima M, Silva N, Hitchcock P. Res Sq, 2023 Sep 18;Journal ArticleCommon and divergent gene regulatory networks control injury-induced and developmental neurogenesis in zebrafish retina.
DOI:10.21203/rs.3.rs-3294233/v1 PMID: 37790324 -
Lyu P, Iribarne M, Serjanov D, Zhai Y, Hoang T, Campbell LJ, Boyd P, Palazzo I, Nagashima M, Silva NJ, HItchcock PF, Qian J, Hyde DR, Blackshaw S. 2023 Aug 8;PreprintCommon and divergent gene regulatory networks control injury-induced and developmental neurogenesis in zebrafish retina.
DOI:10.1101/2023.08.08.552451 PMID: 37609307
Department News
"Robust reprogramming of glia into neurons by inhibition of Notch signaling and nuclear factor I (NFI) factors in adult mammalian retina," has been published in Science Advances.
