Thanh Hoang, PhD
Assistant Professor of Ophthalmology and Visual Sciences
Assistant Professor of Cell and Developmental Biology
Medical School
[email protected]

Available to mentor
Thanh Hoang, PhD
Assistant Professor
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    Research Overview

    The central nervous system (CNS) is a highly complex structure composed of diverse subtypes of neurons and glia. Neurons in the retina, like elsewhere in the CNS, are highly susceptible to diseases, and their loss often result in blindness. Our research focuses on studying cell type specification during neural development and regeneration of lost neurons via cell fate reprogramming as a potential therapy for neurodegenerative diseases. Using a combination of multiomic and genetic tools, We are particularly interested in exploring the regenerative capacity and neuroprotective roles of glial cells: retinal Müller glia and astrocytes, in injury and neurodegenerative disorders.https://hoanglabregen.com/

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    • Hoang Lab
    Recent Publications See All Publications
    • Journal Article
      Viral-mediated Pou5f1 (Oct4) overexpression and inhibition of Notch signaling synergistically induce neurogenic competence in mammalian Müller glia.
      Le N, Awad S, Palazzo I, Hoang T, Blackshaw S. Elife, 2025 May 19; 14: DOI:10.7554/eLife.106450
      PMID: PMC12088672
    • Journal Article
      A combination treatment based on drug repurposing demonstrates mutation-agnostic efficacy in pre-clinical retinopathy models
      Leinonen H, Zhang J, Occelli LM, Seemab U, Choi EH, Luis LF, Querubin J, Kolesnikov AV, Galinska A, Kordecka K, Hoang T, Lewandowski D, Lee TT, Einstein EE, Einstein DE, Dong Z, Kiser PD, Blackshaw S, Kefalov VJ, Tabaka M, Foik A, Petersen-Jones SM, Palczewski K. Nature Communications, 2024 Dec 1; 15 (1): DOI:10.1038/s41467-024-50033-5
      PMID: 39009597
    • Journal Article
      A large-scale CRISPR screen reveals context-specific genetic regulation of retinal ganglion cell regeneration
      Emmerich K, Hageter J, Hoang T, Lyu P, Sharrock AV, Ceisel A, Thierer J, Chunawala Z, Nimmagadda S, Palazzo I, Matthews F, Zhang L, White DT, Rodriguez C, Graziano G, Marcos P, May A, Mulligan T, Reibman B, Saxena MT, Ackerley DF, Qian J, Blackshaw S, Horstick E, Mumm JS. Development Cambridge, 2024 Aug 1; 151 (15): DOI:10.1242/dev.202754
      PMID: 39007397
    • Journal Article
      Robust reprogramming of glia into neurons by inhibition of Notch signaling and nuclear factor I (NFI) factors in adult mammalian retina
      Le N, Vu TD, Palazzo I, Pulya R, Kim Y, Blackshaw S, Hoang T. Science Advances, 2024 Jul 12; 10 (28): DOI:10.1126/sciadv.adn2091
      PMID: 38996013
    • Journal Article
      miR-26 Deficiency Causes Alterations in Lens Transcriptome and Results in Adult-Onset Cataract
      Upreti A, Hoang TV, Li M, Tangeman JA, Dierker DS, Wagner BD, Tsonis PA, Liang C, Lachke SA, Robinson ML. Investigative Ophthalmology and Visual Science, 2024 Apr 1; 65 (4): DOI:10.1167/IOVS.65.4.42
      PMID: 38683565
    • Journal Article
      Common and divergent gene regulatory networks control injury-induced and developmental neurogenesis in zebrafish retina
      Lyu P, Iribarne M, Serjanov D, Zhai Y, Hoang T, Campbell LJ, Boyd P, Palazzo I, Nagashima M, Silva NJ, Hitchcock PF, Qian J, Hyde DR, Blackshaw S. Nature Communications, 2023 Dec 1; 14 (1): DOI:10.1038/s41467-023-44142-w
      PMID: 38123561
    • Preprint
      Molecular regulation of retinal regeneration is context specific.
      Emmerich K, Hageter J, Hoang T, Lyu P, Sharrock AV, Ceisel A, Thierer J, Chunawala Z, Nimmagadda S, Palazzo I, Matthews F, Zhang L, White DT, Rodriquez C, Graziano G, Marcos P, May A, Mulligan T, Reibman B, Saxena MT, Ackerley DF, Qian J, Blackshaw S, Horstick E, Mumm JS. 2023 Nov 21; DOI:10.1101/2023.11.20.567904
      PMID: 38045256
    • Journal Article
      Common and divergent gene regulatory networks control injury-induced and developmental neurogenesis in zebrafish retina.
      Blackshaw S, Lyu P, Zhai Y, Qian J, Iribarne M, Serjanov D, Campbell L, Boyd P, Hyde D, Palazzo I, Hoang T, Nagashima M, Silva N, Hitchcock P. Res Sq, 2023 Sep 18; DOI:10.21203/rs.3.rs-3294233/v1
      PMID: PMC10543505
    Featured News & Stories
    Department News
    New Publication from the Hoang Lab!
    "Robust reprogramming of glia into neurons by inhibition of Notch signaling and nuclear factor I (NFI) factors in adult mammalian retina," has been published in Science Advances.