Thanh Hoang, PhD
Assistant Professor
[email protected]

Available to mentor

Thanh Hoang, PhD
Assistant Professor
  • Research Overview
  • Links
  • Recent Publications
  • Research Overview

    The central nervous system (CNS) is a highly complex structure composed of diverse subtypes of neurons and glia. Neurons in the retina, like elsewhere in the CNS, are highly susceptible to diseases, and their loss often result in blindness. Our research focuses on studying cell type specification during neural development and regeneration of lost neurons via cell fate reprogramming as a potential therapy for neurodegenerative diseases. Using a combination of multiomic and genetic tools, We are particularly interested in exploring the regenerative capacity and neuroprotective roles of glial cells: retinal Müller glia and astrocytes, in injury and neurodegenerative disorders.https://hoanglabregen.com/

    Links
    • Hoang Lab
    Recent Publications See All Publications
    • Journal Article
      A combination treatment based on drug repurposing demonstrates mutation-agnostic efficacy in pre-clinical retinopathy models.
      Leinonen H, Zhang J, Occelli LM, Seemab U, Choi EH, L P Marinho LF, Querubin J, Kolesnikov AV, Galinska A, Kordecka K, Hoang T, Lewandowski D, Lee TT, Einstein EE, Einstein DE, Dong Z, Kiser PD, Blackshaw S, Kefalov VJ, Tabaka M, Foik A, Petersen-Jones SM, Palczewski K. Nat Commun, 2024 Jul 15; 15 (1): 5943 DOI:10.1038/s41467-024-50033-5
      PMID: 39009597
    • Journal Article
      A large-scale CRISPR screen reveals context-specific genetic regulation of retinal ganglion cell regeneration.
      Emmerich K, Hageter J, Hoang T, Lyu P, Sharrock AV, Ceisel A, Thierer J, Chunawala Z, Nimmagadda S, Palazzo I, Matthews F, Zhang L, White DT, Rodriguez C, Graziano G, Marcos P, May A, Mulligan T, Reibman B, Saxena MT, Ackerley DF, Qian J, Blackshaw S, Horstick E, Mumm JS. Development, 2024 Aug 1; 151 (15): DOI:10.1242/dev.202754
      PMID: 39007397
    • Journal Article
      Robust reprogramming of glia into neurons by inhibition of Notch signaling and nuclear factor I (NFI) factors in adult mammalian retina.
      Le N, Vu T-D, Palazzo I, Pulya R, Kim Y, Blackshaw S, Hoang T. Sci Adv, 2024 Jul 12; 10 (28): eadn2091 DOI:10.1126/sciadv.adn2091
      PMID: 38996013
    • Journal Article
      miR-26 Deficiency Causes Alterations in Lens Transcriptome and Results in Adult-Onset Cataract.
      Upreti A, Hoang TV, Li M, Tangeman JA, Dierker DS, Wagner BD, Tsonis PA, Liang C, Lachke SA, Robinson ML. Invest Ophthalmol Vis Sci, 2024 Apr 1; 65 (4): 42 DOI:10.1167/iovs.65.4.42
      PMID: 38683565
    • Journal Article
      Common and divergent gene regulatory networks control injury-induced and developmental neurogenesis in zebrafish retina.
      Lyu P, Iribarne M, Serjanov D, Zhai Y, Hoang T, Campbell LJ, Boyd P, Palazzo I, Nagashima M, Silva NJ, Hitchcock PF, Qian J, Hyde DR, Blackshaw S. Nat Commun, 2023 Dec 20; 14 (1): 8477 DOI:10.1038/s41467-023-44142-w
      PMID: 38123561
    • Preprint
      Molecular regulation of retinal regeneration is context specific.
      Emmerich K, Hageter J, Hoang T, Lyu P, Sharrock AV, Ceisel A, Thierer J, Chunawala Z, Nimmagadda S, Palazzo I, Matthews F, Zhang L, White DT, Rodriquez C, Graziano G, Marcos P, May A, Mulligan T, Reibman B, Saxena MT, Ackerley DF, Qian J, Blackshaw S, Horstick E, Mumm JS. 2023 Nov 21; DOI:10.1101/2023.11.20.567904
      PMID: 38045256
    • Journal Article
      Common and divergent gene regulatory networks control injury-induced and developmental neurogenesis in zebrafish retina.
      Blackshaw S, Lyu P, Zhai Y, Qian J, Iribarne M, Serjanov D, Campbell L, Boyd P, Hyde D, Palazzo I, Hoang T, Nagashima M, Silva N, Hitchcock P. Res Sq, 2023 Sep 18; DOI:10.21203/rs.3.rs-3294233/v1
      PMID: 37790324
    • Preprint
      Common and divergent gene regulatory networks control injury-induced and developmental neurogenesis in zebrafish retina.
      Lyu P, Iribarne M, Serjanov D, Zhai Y, Hoang T, Campbell LJ, Boyd P, Palazzo I, Nagashima M, Silva NJ, HItchcock PF, Qian J, Hyde DR, Blackshaw S. 2023 Aug 8; DOI:10.1101/2023.08.08.552451
      PMID: 37609307
    Featured News & Stories
    Department News
    New Publication from the Hoang Lab!
    "Robust reprogramming of glia into neurons by inhibition of Notch signaling and nuclear factor I (NFI) factors in adult mammalian retina," has been published in Science Advances.