Patrice E Fort
Associate Director
Department of Neuroscience Graduate Program
Associate Professor of Ophthalmology and Visual Sciences
Associate Professor of Molecular and Integrative Physiology
Department of Ophthalmology and Visual Sciences
1000 Wall Street
Ann Arbor, MI 48105
[email protected]

Available to mentor

Patrice E Fort
Associate Professor
  • About
  • Links
  • Qualifications
  • Center Memberships
  • Research Overview
  • Recent Publications
  • About

    Dr Fort is a trained neuroscientist focusing on the neuroretina and the neuro-glial interaction. Dr Fort did his undergraduate studies at the Claude Bernard University in Lyon (France) before a master’s degree in neuroscience and a Doctorate in Living Sciences from the Louis Pasteur University in Strasbourg (France) with Dr Alvaro Rendon and Pr Jose Sahel at the Vision Institute in Paris (France). During his Ph.D., he uncovered unknown key roles of one of the dystrophin isoforms called Dp71, one as a key player in the regulation of retinal homeostasis by Müller glial cells, and the other as a critical protein for maintenance of lens transparency.

    Following his Ph.D., Dr Fort pursued is training at the Penn State University (Hershey, PA) where he continued to gain knowledge of retinal physiology and how it is affected by metabolic and neurodegenerative diseases. As he joined the laboratory of Dr. Gardner for his postdoctoral fellowship, he started studying how diabetes affects retinal metabolism and specifically, protein synthesis. This led to the identification of novel mechanisms of regulation of protein synthesis, specific to the retina and different from other insulin-sensitive tissues. During this time, he also identified previously unknown proteome changes, including effects on intrinsic protective mechanisms critical for cellular survival, using proteomic-based discovery approaches. Dr Fort was recruited by the University of Michigan Kellogg Eye Center in December 2010 as an assistant professor of the department of Ophthalmology and Visual Science, where he focuses on the function and regulation of these intrinsic protective mechanisms in acute and chronic retinal neurodegenerative disorders. Dr. Fort later joined the program of Cellular and Molecular Biology (CMB) as well as the department of molecular and Integrative Physiology (MIP) and the Neuroscience graduate program (NGP) of the University of Michigan in which he participates in recruitment and training of graduate students.

    Links
    • https://sites.google.com/a/umich.edu/patrice-fort-lab/home?authuser=0
    • https://medicine.umich.edu/dept/ophthalmology/patrice-e-fort-phd-ms#websites
    Qualifications
    • Fellowship
      Penn State Hershey College of Medicine, Ophthalmology, 2008
    Center Memberships
    • Center Member
      Caswell Diabetes Institute
    • Center Member
      Global REACH
    • Center Member
      Center for Cell Plasticity and Organ Design
    Research Overview

    The main research interest of Dr. Fort's laboratory are:
    1. Intrinsic retinal neuron survival mechanisms
    2. Retinal glial cells implications in pathological and normal retinal functions
    3. Hsp/Crystallin protein functions in the retina
    4. Signaling pathways regulation
    5. Regulation of the retinal inflammatory response

    Recent Publications See All Publications
    • Journal Article
      Novel mTORC2/HSPB4 Interaction: Role and Regulation of HSPB4 T148 Phosphorylation
      Sluzala ZB, Shan Y, Elghazi L, Cárdenas EL, Hamati A, Garner AL, Fort PE. Cells, 13 (23): 2000 DOI:10.3390/cells13232000
    • Journal Article
      Induction of a Müller glial-specific protective pathway safeguards the retina from diabetes induced damage.
      Lin C-H, Wu M-R, Tanasa B, Prakhar P, Deng B, Davis AE, Li L, Xia A, Shan Y, Fort PE, Wang S. Diabetes, 2024 Oct 24; DOI:10.2337/db24-0199
      PMID: 39446557
    • Presentation
      AlphaA-crystallin and the regulation of the metabolic-stress induced gliotic response.
      Fort P. 2024 Oct;
    • Journal Article
      HSPB4/CRYAA Protect Photoreceptors during Retinal Detachment in Part through FAIM2 Regulation.
      Besirli CG, Nath M, Yao J, Pawar M, Myers AM, Zacks D, Fort PE. Neurol Int, 2024 Aug 26; 16 (5): 905 - 917. DOI:10.3390/neurolint16050068
      PMID: 39311341
    • Preprint
      Induction of a Müller glial-specific protective pathway safeguards the retina from diabetes induced damage
      Lin C-H, Wu M-R, Tanasa B, Prakhar P, Davis AE, Li L, Xia A, Shan Y, Fort PE, Wang S. bioRxiv, DOI:10.1101/2024.06.10.598362
    • Journal Article
      A New Approach to Staging Diabetic Eye Disease: Staging of Diabetic Retinal Neurodegeneration and Diabetic Macular Edema.
      Channa R, Wolf RM, Simo R, Brigell M, Fort P, Curcio C, Lynch S, Verbraak F, Abramoff MD, Diabetic Retinal Neurodegeneration and Macular Edema working group of the Mary Tyler Moore Vision Initiative’s Diabetic Retinal Disease Staging Update Project . Ophthalmol Sci, 2024 4 (3): 100420 DOI:10.1016/j.xops.2023.100420
      PMID: 38284099
    • Preprint
      Modelling human neuronal catecholaminergic pigmentation in rodents recapitulates age-related multisystem neurodegenerative deficits
      Laguna A, Peñuelas N, Gonzalez-Sepulveda M, Nicolau A, Arthaud S, Guillard-Sirieix C, Lorente-Picón M, Compte J, Miquel-Rio L, Xicoy H, Liu J, Parent A, Cuadros T, Romero-Giménez J, Pujol G, Giménez-Llort L, Fort P, Bortolozzi A, Carballo-Carbajal I, Vila M. bioRxiv, DOI:10.1101/2023.08.08.552400
    • Journal Article
      Frontiers in diabetic retinal disease.
      Torm MEW, Dorweiler TF, Fickweiler W, Levine SR, Fort PE, Sun JK, Gardner TW. J Diabetes Complications, 2023 Feb; 37 (2): 108386 DOI:10.1016/j.jdiacomp.2022.108386
      PMID: 36608490