Lezio Soares Bueno, Jr, PhD
Research Investigator
Psychiatry
109 Zina Pitcher Place
Ann Arbor
MI, 48109 United States
[email protected]

Available to mentor
Lezio Soares Bueno, Jr, PhD
Research Investigator
  • About
  • Qualifications
  • Research Overview
  • Recent Publications
    • About

    BSc in Biology, MSc in Psychology, and PhD in Neuroscience from the University of Sao Paulo in Ribeirao Preto (2000-2012). Postdoc in Neuroscience at the University of Pittsburgh, University of Sao Paulo in Ribeirao Preto, and University of Michigan Medical School (2013-2022). Currently Research Faculty at the University of Michigan Medical School, Department of Psychiatry, in collaboration with Oregon Health & Science University and VA Portland.

    Specialized in rodent behavior and physiology using techniques such as appetitive conditioning, brain stimulation/recording, drug delivery and machine vision. Also experienced in the analysis of human EEG. Currently interested in the temporal structure of REM sleep, as well as the relationships between sleep architecture and disorders affecting mood and social affiliation.

    Mentors: Jose Lino O. Bueno, Rodrigo N. Romcy-Pereira, Joao P. Leite, Bita Moghaddam, Brendon O. Watson, Miranda M. Lim.

    Qualifications
    • Postdoctoral Research Fellowship
      University of Michigan–Ann Arbor, Ann Arbor, 2022
    • Postdoctoral Research Fellowship
      University of Sao Paulo in Ribeirao Preto, Neuroscience, 2018
    • Postdoctoral Research Fellowship
      University of Pittsburgh, Neuroscience, 2014
    • PhD
      University of Sao Paulo in Ribeirao Preto, Brazil, 2012
    • MSc
      University of Sao Paulo in Ribeirao Preto, Brazil, 2008
    • BSc
      University of Sao Paulo in Ribeirao Preto, Brazil, 2005
    Research Overview

    Current interests:

    - Temporal structure of REM sleep
    - Behavioral and physiological markers of social bonding
    - Impact of both learning and arousal states on neocortical activity
    - Sleep architecture alterations in psychiatric disease

    Recent Publications See All Publications
    • Journal Article
      Quantifying social roles in multi-animal videos using subject-aware deep-learning.
      Goss K, Bueno-Junior LS, Stangis K, Ardoin T, Carmon H, Zhou J, Satapathy R, Baker I, Jones-Tinsley CE, Lim MM, Watson BO, Sueur C, Ferrario CR, Murphy GG, Ye B, Hu Y. bioRxiv, 2024 Jul 10; DOI:10.1101/2024.07.07.602350
      PMID: 39026890
    • Journal Article
      Early-life sleep disruption impairs subtle social behaviours in prairie voles: a pose-estimation study.
      Bueno-Junior LS, Jones-Tinsley CE, Milman NEP, Wickham PT, Watson BO, Lim MM. R Soc Open Sci, 2023 Jul; 10 (7): 230700 DOI:10.1098/rsos.230700
      PMID: 37448475
    • Journal Article
      Dysfunctional hippocampal-prefrontal network underlies a multidimensional neuropsychiatric phenotype following early-life seizure.
      Ruggiero RN, Marques DB, Rossignoli MT, De Ross JB, Prizon T, Beraldo IJS, Bueno-Junior LS, Kandratavicius L, Peixoto-Santos JE, Lopes-Aguiar C, Leite JP. Elife, 2024 Apr 9; 12: DOI:10.7554/eLife.90997
      PMID: 38593008
    • Journal Article
      The temporal structure of REM sleep shows minute-scale fluctuations across brain and body in mice and humans.
      Bueno-Junior LS, Ruckstuhl MS, Lim MM, Watson BO. Proc Natl Acad Sci U S A, 2023 May 2; 120 (18): e2213438120 DOI:10.1073/pnas.2213438120
      PMID: 37094161
    • Journal Article
      Editorial: Psychiatric Comorbidities in the Epilepsies: Extensive Mechanisms and Broad Questions.
      Ruggiero RN, Peixoto-Santos JE, Bueno-Junior LS, Valente KD, Leite JP. Front Integr Neurosci, 2022 16: 951170 DOI:10.3389/fnint.2022.951170
      PMID: 35784497
    • Journal Article
      Prediction of Learned Resistance or Helplessness by Hippocampal-Prefrontal Cortical Network Activity during Stress.
      Marques DB, Ruggiero RN, Bueno-Junior LS, Rossignoli MT, Leite JP. J Neurosci, 2022 Jan 5; 42 (1): 81 - 96. DOI:10.1523/JNEUROSCI.0128-21.2021
      PMID: 34772738
    • Journal Article
      Interaction between hippocampal-prefrontal plasticity and thalamic-prefrontal activity.
      Bueno-Junior LS, Peixoto-Santos JE, Ruggiero RN, Ávila MAV, Marques DB, Lopes-Aguiar C, Leite JP. Sci Rep, 2018 Jan 22; 8 (1): 1382 DOI:10.1038/s41598-018-19540-6
      PMID: 29358657
    • Journal Article
      Lithium modulates the muscarinic facilitation of synaptic plasticity and theta-gamma coupling in the hippocampal-prefrontal pathway.
      Ruggiero RN, Rossignoli MT, Lopes-Aguiar C, Leite JP, Bueno-Junior LS, Romcy-Pereira RN. Exp Neurol, 2018 Jun; 304: 90 - 101. DOI:10.1016/j.expneurol.2018.02.011
      PMID: 29458058