Amarbir S Gill, MD

I am an Assistant Professor of Otolaryngology and surgeon-scientist at the University of Michigan (UM). Both my clinical practice and my research career focus on chronic rhinosinusitis (CRS), an upper airway inflammatory disorder. To this end, I have published over 40 papers on CRS, focusing on disease pathophysiology and mechanisms, environmental exposures, and disease outcomes. I have presented my findings biannually at national conferences during the past 4 years.

My team and I seek to understand the molecular mechanisms driving the development and progression of chronic rhinosinusitis with nasal polyps (CRSwNP), a type 2 inflammatory subtype of CRS. I have expertise in CRSwNP disease phenotyping and endotyping, as well as in elucidation of molecular pathways and targets. My translational research effort combines patient tissue specimen analyses with cell culture and mouse models. My main areas of research focus are: 1) the contribution of macrophages and lipid metabolites to CRSwNP development and disease progression; 2) the differential pathogenic potential of wildfire vs. non-wildfire PM2.5 exposures on CRSwNP; and 3) the development of novel, topical therapeutics strategies for improving CRS outcomes.