Assistant Professor of Anesthesiology
Program Assistant, Anesthesiology
[email protected]
Available to mentor
Stephan Frangakis, MD, PhD
Assistant Professor
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FellowshipDuke University Hospital, Regional Anesthesiology and Acute Pain Medicine, Department of Anesthesiology, 2021
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ResidencyDuke University Hospital, Clinical Anesthesiology Department of Anesthesiology, 2020
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Clinical InternshipDuke University Hospital, Department of Anesthesiology, 2017
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M.D.Duke University School of Medicine, Durham, North Carolina, 2016
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Ph.D.Duke University School of Medicine, Durham, North Carolina, 2015
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B.A.Rutgers, The State University of New Jersey, New Brunswick, 2006
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Center MemberPrecision Health Initiative
My research interests include genetic and physiologic factors predisposing to the development of acute postoperative pain, and the transition to chronic postoperative pain. Additionally, I am interested in adjuvants and techniques to prevent postoperative pain.
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Mosley JD, Shelley JP, Dickson AL, Zanussi J, Daniel LL, Zheng NS, Bastarache L, Wei W-Q, Shi M, Jarvik GP, Rosenthal EA, Khan A, Sherafati A, Kullo IJ, Walunas TL, Glessner J, Hakonarson H, Cox NJ, Roden DM, Frangakis SG, Vanderwerff B, Stein CM, Van Driest SL, Borinstein SC, Shu X-O, Zawistowski M, Chung CP, Kawai VK. Nat Commun, 2024 Apr 22; 15 (1): 3384Journal ArticleClinical associations with a polygenic predisposition to benign lower white blood cell counts.
DOI:10.1038/s41467-024-47804-5 PMID: 38649760 -
Frangakis SG, Brummett CM. Anesthesiology, 2024 Aug 1; 141 (2): 211 - 213.Journal ArticlePainstaking Progress: A Call for Comprehensive Research and Consistent Outcome Measures of Postsurgical Pain.
DOI:10.1097/ALN.0000000000005072 PMID: 38980162 -
Frangakis SG, Kavalakatt B, Gunaseelan V, Lai Y, Waljee J, Englesbe M, Brummett CM, Bicket MC. Ann Surg, 2024 Mar 14;Journal ArticleThe Association of Preoperative Opioid Use with Post-Discharge Outcomes: A Cohort Study of the Michigan Surgical Quality Collaborative.
DOI:10.1097/SLA.0000000000006265 PMID: 38482687 -
Annis AC, Gunaseelan V, Smith AV, Abecasis GR, Larach DB, Zawistowski M, Frangakis SG, Brummett CM. Genet Epidemiol, 2024 Oct 9;Journal ArticleGenetic Associations of Persistent Opioid Use After Surgery Point to OPRM1 but Not Other Opioid-Related Loci as the Main Driver of Opioid Use Disorder.
DOI:10.1002/gepi.22588 PMID: 39385445 -
Ramo S, Frangakis S, Waljee JF, Bicket MC. Reg Anesth Pain Med, 2024 Sep 11;Journal ArticleRisk factors for persistent postoperative opioid use: an entity distinct from chronic postsurgical pain.
DOI:10.1136/rapm-2024-105599 PMID: 39266222 -
Brummett C, Annis A, Gunaseelan V, Smith A, Abecasis G, Larach D, Zawistowski M, Frangakis S. Research Square,PreprintGenetic associations of persistent opioid use after surgery: a hypothesis-driven analysis of high-value genetic variants in the Michigan Genomics Initiative dataset
DOI:10.21203/rs.3.rs-3175786/v1 -
Mosley JD, Shelley JP, Dickson AL, Zanussi J, Daniel LL, Zheng NS, Bastarache L, Wei W-Q, Shi M, Jarvik GP, Rosenthal EA, Khan A, Sherafati A, Kullo IJ, Walunas TL, Glessner J, Hakonarson H, Cox NJ, Roden DM, Frangakis SG, Vanderwerff B, Stein CM, Van Driest SL, Borinstein SC, Shu X-O, Zawistowski M, Chung CP, Kawai VK. 2023 Aug 21;PreprintClinical consequences of a polygenic predisposition to benign lower white blood cell counts: Consequences of benign WBC count genetics.
DOI:10.1101/2023.08.20.23294331 PMID: 37662324 -
Frangakis S. 2023 May 31;PresentationUsing Electronic Health Records to Generate algorithm Phenotypes for Chronic Post-Surgical Pain (CPSP)
Department News
The project will be the largest postsurgical pain genetics study to date.
