Di Chen, PhD
Research Investigator
Microbiology and Immunology
Department of Microbiology and Immunology
1150 West Medical Center Drive
Ann Arbor, Michigan 48109
[email protected]

Available to mentor
Di Chen, PhD
Research Investigator
  • Qualifications
  • Recent Publications
    • Qualifications
    • Postdoctoral Research Fellow
      University of Michigan Medical School, Department of Microbiology and Immunology, 2021
    • Postdoctoral Research Fellow
      Shanghai Institute of Nutrition and Health, Shanghai, 2015
    • PhD
      Huazhong University of Science and Technology, Wuhan, 2013
    • MS
      Hubei University, Wuhan, 2007
    • BSc
      China Three Gorges University, Yichang, 2004
    Recent Publications See All Publications
    • Journal Article
      A temporally-restricted pattern of endothelial cell collagen 4 alpha 1 expression during embryonic development determined with a novel knockin Col4a1-P2A-eGFP mouse line.
      Lartey NL, van der Ent M, Alonzo R, Chen D, King PD. Genesis, 2024 Feb; 62 (1): e23539 DOI:10.1002/dvg.23539
      PMID: 37501352
    • Journal Article
      Mutation of key signaling regulators of cerebrovascular development in vein of Galen malformations.
      Zhao S, Mekbib KY, van der Ent MA, Allington G, Prendergast A, Chau JE, Smith H, Shohfi J, Ocken J, Duran D, Furey CG, Hao LT, Duy PQ, Reeves BC, Zhang J, Nelson-Williams C, Chen D, Li B, Nottoli T, Bai S, Rolle M, Zeng X, Dong W, Fu P-Y, Wang Y-C, Mane S, Piwowarczyk P, Fehnel KP, See AP, Iskandar BJ, Aagaard-Kienitz B, Moyer QJ, Dennis E, Kiziltug E, Kundishora AJ, DeSpenza T, Greenberg ABW, Kidanemariam SM, Hale AT, Johnston JM, Jackson EM, Storm PB, Lang S-S, Butler WE, Carter BS, Chapman P, Stapleton CJ, Patel AB, Rodesch G, Smajda S, Berenstein A, Barak T, Erson-Omay EZ, Zhao H, Moreno-De-Luca A, Proctor MR, Smith ER, Orbach DB, Alper SL, Nicoli S, Boggon TJ, Lifton RP, Gunel M, King PD, Jin SC, Kahle KT. Nat Commun, 2023 Nov 17; 14 (1): 7452 DOI:10.1038/s41467-023-43062-z
      PMID: 37978175
    • Journal Article
      Cutting Edge: Induced Loss of Rasgrp1 in Peripheral CD4+ T Cells of Conditional Rasgrp1-Deficient Mice Reveals an Essential Role for Rasgrp1 in TCR/CD28-Induced Ras-MAPK Signaling.
      Chang Y, Manivannan P, Doosti A, Lapinski PE, Chen D, Roose JP, King PD. J Immunol, 2023 Sep 15; 211 (6): 917 - 922. DOI:10.4049/jimmunol.2300138
      PMID: 37566514
    • Journal Article
      EPHB4-RASA1-Mediated Negative Regulation of Ras-MAPK Signaling in the Vasculature: Implications for the Treatment of EPHB4- and RASA1-Related Vascular Anomalies in Humans.
      Chen D, Van der Ent MA, Lartey NL, King PD. Pharmaceuticals (Basel), 2023 Jan 23; 16 (2): DOI:10.3390/ph16020165
      PMID: 37259315
    • Journal Article
      Angiogenesis depends upon EPHB4-mediated export of collagen IV from vascular endothelial cells.
      Chen D, Hughes ED, Saunders TL, Wu J, Vasquez MNH, Makinen T, King PD. JCI Insight, 2022 Feb 22; 7 (4): DOI:10.1172/jci.insight.156928
      PMID: 35015735
    • Journal Article
      Macropinocytosis drives T cell growth by sustaining the activation of mTORC1.
      Charpentier JC, Chen D, Lapinski PE, Turner J, Grigorova I, Swanson JA, King PD. Nat Commun, 2020 Jan 10; 11 (1): 180 DOI:10.1038/s41467-019-13997-3
      PMID: 31924779
    • Journal Article
      RASA1-driven cellular export of collagen IV is required for the development of lymphovenous and venous valves in mice.
      Chen D, Geng X, Lapinski PE, Davis MJ, Srinivasan RS, King PD. Development, 2020 Dec 7; 147 (23): DOI:10.1242/dev.192351
      PMID: 33144395
    • Journal Article
      Loss of DP1 Aggravates Vascular Remodeling in Pulmonary Arterial Hypertension via mTORC1 Signaling.
      He Y, Zuo C, Jia D, Bai P, Kong D, Chen D, Liu G, Li J, Wang Y, Chen G, Yan S, Xiao B, Zhang J, Piao L, Li Y, Deng Y, Li B, Roux PP, Andreasson KI, Breyer RM, Su Y, Wang J, Lyu A, Shen Y, Yu Y. Am J Respir Crit Care Med, 2020 May 15; 201 (10): 1263 - 1276. DOI:10.1164/rccm.201911-2137OC
      PMID: 31917615