Arushi Varshney, PhD
Research Investigator
Computational Medicine and Bioinformatics
Department of Computational Medicine & Bioinformatics
100 Washtenaw Ave., 2049 Palmer Commons
Ann Arbor, MI 48109
[email protected]

Available to mentor
Arushi Varshney, PhD
Research Investigator
  • Qualifications
  • Research Overview
  • Links
  • Recent Publications
    • Qualifications
    • Doctor of Philosophy (PhD) in Human Genetics
      University of Michigan, Ann Arbor, MI, 2019
    • Master of Science (MS) in Bioengineering
      Swiss Federal Institute of Technology, Lausanne, 2014
    • Bachelor of Technology (BTech) in Biotechnology
      Indian Institute of Technology Guwahati, Assam, 2012
    Research Overview

    Through my research, I am to better understand how predisposition to complex metabolic diseases such as type 2 diabetes (T2D) is encoded in our DNA. I employ computational and statistical approaches to analyze large high-throughput data sets on the genome, epigenome, and transcriptome in disease-relevant tissues/cells to understand biological mechanisms of gene regulation.

    Links
    • Google Scholar
    • GitHub
    Recent Publications See All Publications
    • Journal Article
      1468-P: Massively Parallel Reporter Assay Reveals Position-, Promoter-, and Strand-Dependent Effects in Islet TSSs Overlapping Type 2 Diabetes GWAS Loci
      BOSE ML, TOVAR A, VARSHNEY A, PARKER S, KITZMAN J, KYONO Y. Diabetes, 2024 Jun 14; 73 (Supplement_1): DOI:10.2337/db24-1468-p
    • Journal Article
      2005-LB: Optimization of Single Nuclei Isolation from Frozen Human Skeletal Muscle and Pancreatic Tissue Samples for Single Nuclei Multiome ATAC + Gene Expression
      DOLGACHEV V, VARSHNEY A, MOO KG, WANG X, ORCHARD P, SAUNDERS DC, BRISSOVA M, PARKER SC. Diabetes, 2024 Jun 14; 73 (Supplement_1): DOI:10.2337/db24-2005-lb
    • Journal Article
      2009-LB: Deep Learning Enhances Chromatin Accessibility Signals and Discovers Links with Genetic Variations in Skeletal Muscle Rare Cells
      VU HTH, VARSHNEY A, ORCHARD P, LAAKSO M, TUOMILEHTO J, LAKKA TA, MOHLKE KL, BOEHNKE M, SCOTT L, KOISTINEN HA, COLLINS FS, PARKER SC. Diabetes, 2024 Jun 14; 73 (Supplement_1): DOI:10.2337/db24-2009-lb
    • Journal Article
      2012-LB: Type 2 Diabetes GWAS Signal C2CD4A/B Insulin Resistance Mechanisms in Skeletal Muscle
      EPELLE IL, VARSHNEY A, ORCHARD P, ZHANG Z, FENG F, LAAKSO M, TUOMILEHTO J, LAKKA TA, MOHLKE KL, BOEHNKE M, SCOTT L, KOISTINEN HA, COLLINS FS, LIU J, PARKER SC. Diabetes, 2024 Jun 14; 73 (Supplement_1): DOI:10.2337/db24-2012-lb
    • Journal Article
      2013-LB: Population-Scale Skeletal Muscle Single-Nucleus Multiomic Profiling Reveals Extensive Context-Specific Genetic Regulation
      VARSHNEY A, MANICKAM N, ORCHARD P, TOVAR A, ZHANG Z, FENG F, LAKKA TA, LAAKSO M, TUOMILEHTO J, MOHLKE KL, KITZMAN J, KOISTINEN HA, LIU J, BOEHNKE M, COLLINS FS, SCOTT L, PARKER SC. Diabetes, 2024 Jun 14; 73 (Supplement_1): DOI:10.2337/db24-2013-lb
    • Proceeding / Abstract / Poster
      210-OR: ADA Presidents' Select Abstract: Discovering Stimulatory State-Specific Type 2 Diabetes GWAS Mechanisms with Single-Cell Multiomics on iPSC-Derived Fibro-adipogenic Progenitor Cell Villages
      VENTRESCA C, VARSHNEY A, ORCHARD P, TSAN Y-C, MONTEIRO DA ROCHA A, LAAKSO M, TUOMILEHTO J, LAKKA TA, MOHLKE KL, BOEHNKE M, SCOTT L, KOISTINEN HA, COLLINS FS, HERRON TJ, BIELAS S, PARKER S. Diabetes, 2024 Jun 14; 73 (Supplement_1): DOI:10.2337/db24-210-or
    • Journal Article
      212-OR: Differential Cell-Type - Specific Gene Expression and Chromatin Accessibility by Type 2 Diabetes Status and Physical Activity Levels in Human Skeletal Muscle
      CIOTLOS D, HANKS S, VARSHNEY A, ERDOS M, MANICKAM N, STRINGHAM HM, HILL-BURNS E, ORCHARD P, NARISU N, BONNYCASTLE LL, SWEENEY MD, LAAKSO M, TUOMILEHTO J, LAKKA TA, MOHLKE KL, BOEHNKE M, KOISTINEN HA, COLLINS FS, PARKER S, SCOTT L. Diabetes, 2024 Jun 14; 73 (Supplement_1): DOI:10.2337/db24-212-or
    • Journal Article
      213-OR: Widespread Age-Associated Changes in the Chromatin Architecture of Skeletal Muscle Cell Types
      MOO KG, D'OLIVEIRA ALBANUS R, VARSHNEY A, ORCHARD P, MANICKAM N, LAAKSO M, TUOMILEHTO J, LAKKA TA, MOHLKE KL, BOEHNKE M, SCOTT L, KOISTINEN HA, COLLINS FS, PARKER S. Diabetes, 2024 Jun 14; 73 (Supplement_1): DOI:10.2337/db24-213-or