Anoop Arunagiri
Center Member
[email protected]

Available to mentor
Anoop Arunagiri
Center Member
  • About
  • Links
  • Qualifications
  • Center Memberships
  • Research Overview
  • Recent Publications
    • About

    I am a biochemist currently studying proinsulin folding and misfolding in pancreatic beta cells

    Links
    Qualifications
    • Postdoctoral Research Fellow
      University of Michigan, Internal Medicine, 2020
    • Ph.D.
      Indian Institute of Technology Bombay, Mumbai, 2016
    • M.Sc.
      Alagappa University, Karaikudi, 2008
    Center Memberships
    • Center Member
      Caswell Diabetes Institute
    Research Overview

    Interested in studying protein folding problems relevant to metabolic disorders and degenerative diseases
    utilizing biochemical, biophysical, and cell biological approaches

    Recent Publications See All Publications
    • Presentation
      Hrd1 deficiency in pancreatic beta cells
      Arunagiri A. 2024 May 2;
    • Journal Article
      Proinsulin folding and trafficking defects trigger a common pathological disturbance of endoplasmic reticulum homeostasis.
      Arunagiri A, Alam M, Haataja L, Draz H, Alasad B, Samy P, Sadique N, Tong Y, Cai Y, Shakeri H, Fantuzzi F, Ibrahim H, Jang I, Sidarala V, Soleimanpour SA, Satin LS, Otonkoski T, Cnop M, Itkin-Ansari P, Kaufman RJ, Liu M, Arvan P. Protein Sci, 2024 Apr; 33 (4): e4949 DOI:10.1002/pro.4949
      PMID: 38511500
    • Journal Article
      Restoration of PITPNA in Type 2 diabetic human islets reverses pancreatic beta-cell dysfunction.
      Yeh Y-T, Sona C, Yan X, Li Y, Pathak A, McDermott MI, Xie Z, Liu L, Arunagiri A, Wang Y, Cazenave-Gassiot A, Ghosh A, von Meyenn F, Kumarasamy S, Najjar SM, Jia S, Wenk MR, Traynor-Kaplan A, Arvan P, Barg S, Bankaitis VA, Poy MN. Nat Commun, 2023 Jul 17; 14 (1): 4250 DOI:10.1038/s41467-023-39978-1
      PMID: 37460527
    • Presentation
      Proinsulin Misfolding Reflects Disturbance of Endoplasmic Reticulum Homeostasis
      Arunagiri A. 2023 Oct 25;
    • Journal Article
      ER stress increases expression of intracellular calcium channel RyR1 to modify Ca2+ homeostasis in pancreatic beta cells.
      Zhang IX, Herrmann A, Leon J, Jeyarajan S, Arunagiri A, Arvan P, Gilon P, Satin LS. J Biol Chem, 2023 Aug; 299 (8): 105065 DOI:10.1016/j.jbc.2023.105065
      PMID: 37468098
    • Journal Article
      Nutrient-dependent regulation of β-cell proinsulin content.
      Xu X, Arunagiri A, Alam M, Haataja L, Evans CR, Zhao I, Castro-Gutierrez R, Russ HA, Demangel C, Qi L, Tsai B, Liu M, Arvan P. J Biol Chem, 2023 Jul; 299 (7): 104836 DOI:10.1016/j.jbc.2023.104836
      PMID: 37209827
    • Proceeding / Abstract / Poster
      Upregulation of ryanodine receptor 1 is involved in ER stress-induced disruption of beta cell calcium homeostasis
      Zhang IX, Hermann A, Leon J, Arunagiri A, Arvan P, Satin LS. Biophysical journal, 2023 Feb 10; 122 (3S1): 234a - 235a. DOI:10.1016/j.bpj.2022.11.1379
    • Journal Article
      Cholesterol Redistribution in Pancreatic β-Cells: A Flexible Path to Regulate Insulin Secretion.
      Galli A, Arunagiri A, Dule N, Castagna M, Marciani P, Perego C. Biomolecules, 2023 Jan 24; 13 (2): DOI:10.3390/biom13020224
      PMID: 36830593