Dogukan Mizrak

 Dogukan Mizrak headshot
Research Assistant Professor
Surgery
Medical School
[email protected]
Available to mentor
Dogukan Mizrak
Dogukan Mizrak headshot
Research Assistant Professor
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    • Center Memberships
    • Center Member
      Samuel and Jean Frankel Cardiovascular Center

    Recent Publications

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    • Journal Article
      Spatially controlled tenascin-C accumulation contributes to inflammatory disease persistence in giant cell aortitis.
      Shi H, Tang Y, Li J, Gewurz-Singer O, Yang B, Mizrak D. JCI Insight, 2026 Apr 8; 11 (7): DOI:10.1172/jci.insight.200255
      PMID: 41948935
    • Journal Article
      Construction of a Three-Dimensional Calcific Aortic Valve Disease Model Using Human iPSC-Derived Valvular Interstitial Cells
      Guo R, Qi Z, Qiu P, Mizrak D, Yang B. Stem Cell Reviews and Reports, 2026 Feb 1; 22 (2): 963 - 975. DOI:10.1007/s12015-025-11030-3
      PMID: 41343103
    • Preprint
      A Marfan-Associated FBN1 Nonsense Mutation Mouse Model Reveals Adventitial Inflammation During Aneurysm Progression.
      Wu S, Zhao J, Ponce A, Pham L, Xie D, Ju D, Yin S, Hernandez F, Jones S, Li C, Chung C, Komnenov D, Rossi NF, Mizrak D, Yang B, Yang Z, Yang M, Li H, Xie Y, Chen K, Zhang K, Li L. 2025 Nov 25; DOI:10.1101/2025.09.23.678101
      PMID: 41040364
    • Journal Article
      Single-cell spatial transcriptomics unravels the cellular landscape of abdominal aortic aneurysm
      Zhao G, Cho CS, Liu H, Hwang Y, Si Y, Kim M, Deng Y, Zhao Y, Xue C, Guo Y, Chang L, Mizrak D, Yang B, Kang HM, Zhang J, Lee JH, Chen YE. JCI Insight, 2025 Aug 25; 10 (16): e190534 - e190534.
    • Journal Article
      TGFBR3 dependent mechanism ofTGFB2 in smooth muscle cell differentiation and implications for TGFB2-related aortic aneurysm
      Tang Y, Cheng J, Huang C, Qiu P, Li J, Chen YE, Mizrak D, Yang B. Stem Cells Translational Medicine, 2025 Mar 1; 14 (3): DOI:10.1093/stcltm/szae101
      PMID: 40139558
    • Journal Article
      Bioengineered vascular grafts with a pathogenic TGFBR1 variant model aneurysm formation in vivo and reveal underlying collagen defects
      Yang Y, Feng H, Tang Y, Wang Z, Qiu P, Huang X, Chang L, Zhang J, Chen YE, Mizrak D, Yang B. Science Translational Medicine, 2024 May 8; 16 (746): DOI:10.1126/scitranslmed.adg6298
      PMID: 38718134
    • Journal Article
      Single-Molecule Spatial Transcriptomics of Human Thoracic Aortic Aneurysms Uncovers Calcification-Related CARTPT-Expressing Smooth Muscle Cells.
      Mizrak D, Zhao Y, Feng H, Macaulay J, Tang Y, Sultan Z, Zhao G, Guo Y, Zhang J, Yang B, Chen YE. Arterioscler Thromb Vasc Biol, 2023 Oct 27; DOI:10.1161/ATVBAHA.123.319329
    • Journal Article
      Bicuspid Aortic Valve-Associated Regulatory Regions Reveal GATA4 Regulation and Function during Human-Induced Pluripotent Stem Cell-Based Endothelial-Mesenchymal Transition - Brief Report
      Huang T, Cheng J, Feng H, Zhou W, Qiu P, Zhou D, Yang D, Zhang J, Willer C, Chen YE, Mizrak D, Yang B. Arteriosclerosis, Thrombosis, and Vascular Biology, 2023 Oct 31; 43 (2): 312 - 322. DOI:10.1161/ATVBAHA.122.318566