Adam C Abraham
Assistant Professor, Orthopaedic Surgery
Orthopaedic Surgery
109 Zina Pitcher
Ann Arbor, MI 48109
[email protected]

Available to mentor
Adam C Abraham
Assistant Professor
  • Qualifications
  • Center Memberships
  • Research Overview
  • Links
  • Recent Publications
    • Qualifications
    • Postdoctoral Research Scientist
      Columbia University Medical Center, Orthopaedic Surgery, 2019
    • Postdoctoral Fellow
      Washington University in St. Louis School of Medicine, Orthopaedic Surgery, 2015
    • PhD
      Colorado State University, Fort Collins, 2013
    • MS
      Michigan Technological University, Houghton, 2008
    • BS
      Michigan Technological University, Houghton, 2006
    Center Memberships
    • Center Member
      Center for Cell Plasticity and Organ Design
    • Center Member
      Biosciences Initiative
    Research Overview

    My multi-disciplinary background spans the fields of mechanical and biomedical engineering with additional training in metabolic diseases and immunology. My research expertise includes multi-scale biomechanics, inflammation, and musculoskeletal disease modeling. My research is focused on:
    1. Musculoskeletal tissue pathophysiology and mechanics
    2. Exercise and overuse mechanobiology of connective soft tissues (e.g. tendons, ligaments, etc.)
    3. Engineering immune-stromal crosstalk during the inflammatory response

    Links
    • Department Profile
    Recent Publications See All Publications
    • Preprint
      Functional Changes to Achilles Tendon and Enthesis in a Mouse Model of an Adolescent Masculine Gender-Affirming Hormone Treatment
      Hold LA, Phillips T, Cordts P, Steltzer S, Bae S-H, Henry B, Migotsky N, Grossman S, Dela Cruz C, Padmanabhan V, Moravek M, Shikanov A, Abraham AC, Killian ML. bioRxiv, DOI:10.1101/2024.06.10.598308
    • Preprint
      Overexpression of enhanced yellow fluorescent protein fused with Channelrhodopsin-2 causes contractile dysfunction in skeletal muscle
      Lamia SN, Davis CS, Macpherson PCD, Willingham TB, Zhang Y, Liu C, Iannucci L, Ganji E, Harden D, Bhattacharya I, Abraham AC, Brooks SV, Glancy B, Killian ML. bioRxiv, DOI:10.1101/2024.06.06.597782
    • Journal Article
      Nuclear factor κB overactivation in the intervertebral disc leads to macrophage recruitment and severe disc degeneration.
      Burt KG, Kim MKM, Viola DC, Abraham AC, Chahine NO. Sci Adv, 2024 Jun 7; 10 (23): eadj3194 DOI:10.1126/sciadv.adj3194
      PMID: 38848366
    • Journal Article
      Interfacial Tissue Regeneration with Bone.
      Steltzer SS, Abraham AC, Killian ML. Curr Osteoporos Rep, 2024 Apr; 22 (2): 290 - 298. DOI:10.1007/s11914-024-00859-1
      PMID: 38358401
    • Journal Article
      A role for TGFβ signaling in Gli1+ tendon and enthesis cells.
      Song L, Golman M, Abraham AC, Zelzer E, Thomopoulos S. FASEB J, 2024 Mar 31; 38 (6): e23568 DOI:10.1096/fj.202301452R
      PMID: 38522021
    • Journal Article
      Engineered Microenvironmental Cues from Fiber-Reinforced Hydrogel Composites Drive Tenogenesis and Aligned Collagen Deposition.
      Kent RN, Jewett ME, Buck TP, Said M, Hold LA, Crawford EA, Killian ML, Abraham AC, Huang AH, Baker BM. Adv Healthc Mater, 2024 Mar 5; e2400529 DOI:10.1002/adhm.202400529
      PMID: 38441411
    • Preprint
      Nuclear Factor Kappa B Over-Activation in the Intervertebral Disc Leads to Macrophage Recruitment and Severe Disc Degeneration.
      Burt KG, Kim MKM, Viola DC, Abraham AC, Chahine NO. 2023 Aug 8; DOI:10.1101/2023.08.07.552274
      PMID: 37609194
    • Journal Article
      Optogenetic-induced muscle loading leads to mechanical adaptation of the Achilles tendon enthesis in mice.
      Ganji E, Lamia SN, Stepanovich M, Whyte N, Goulet RW, Abraham AC, Killian ML. Sci Adv, 2023 Jun 23; 9 (25): eadf4683 DOI:10.1126/sciadv.adf4683
      PMID: 37352350