1301 Catherine Street / 6435 Medical Science Unit I
Ann Arbor, MI 48109
Available to mentor
Vincent van Drongelen, PhD is a Research Investigator in the University of Michigan Department of Dermatology. Dr. van Drongelen has made important contributions to research investigating systemic lupus erythematosus (SLE) and other immune-mediated diseases involving the skin. In collaboration with Dr. Allison Billi, he is studying the female-biased immune regulator “VGLL3” as a driver of sexual dimorphism in autoimmune diseases.
Dr. van Drongelen received his PhD in dermatology from Leiden University Medical Center in Leiden, the Netherlands, where he focused on the contribution of genetic and environmental factors to development of atopic dermatitis. He completed postdoctoral research training in autoimmunity and immunology in the University of Michigan Department of Internal Medicine – Division of Rheumatology and was appointed Research Investigator in Internal Medicine/Rheumatology in 2020. He joined the Billi lab in the University of MIchigan Department of Dermatology in 2022.
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Postdoctoral Research FellowUniversty of Michigan Medical School, Department of Internal Medicine, Division of Rheumatology, 2020
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PhDLeiden University Medical Center, Department of Dermatology; Department of Drug Delivery Technology, 2014
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MScLeiden University Medical Center, Biomedical Sciences, 2009
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BScLeiden University Medical Center, Leiden, 2007
• Uncovering the role of VGLL3 in the development of Systemic Lupus Erythematosus
• Using single cell (sc)RNA-sequencing to characterize rare skin diseases
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van Drongelen V, Young K, Gharaee-Kermani M, Plazyo O, Griffin E, Syu L, Xing E, Ward NL, Tsoi LC, Kahlenberg M, Dlugosz A, Gudjonsson JE, Billi A. Journal of Investigative Dermatology, 2024 May; 144 (8): s3 - s3.Proceeding / Abstract / Poster016 Investigating therapeutic targeting of the female-biased factor VGLL3 in lupus
DOI:10.1016/j.jid.2024.06.032 -
van Drongelen V, Ma F, Tsoi L, Roofeh D, Gudjonsson J, Khanna D, Billi A. Journal of Investigative Dermatology, 2023 May; 143 (5): s155 - s155.Proceeding / Abstract / Poster904 Single-cell RNA-sequencing reveals expansion of vascular associated cells in stiff skin syndrome
DOI:10.1016/j.jid.2023.03.914 -
Miglioranza Scavuzzi B, van Drongelen V, Kaur B, Fox JC, Liu J, Mesquita-Ferrari RA, Kahlenberg JM, Farkash EA, Benavides F, Miller FW, Sawalha AH, Holoshitz J. Commun Biol, 2022 Jul 28; 5 (1): 751Journal ArticleThe lupus susceptibility allele DRB1*03:01 encodes a disease-driving epitope.
DOI:10.1038/s42003-022-03717-x PMID: 35902632 -
Scavuzzi BM, van Drongelen V, Kaur B, Fox JC, Liu J, Mesquita-Ferrari RA, Kahlenberg JM, Farkash EA, Benavides F, Miller FW, Sawalha AH, Holoshitz J. bioRxiv,PreprintThe lupus susceptibility allele DRB1*03:01 encodes a disease-driving epitope
DOI:10.1101/2022.05.31.494172 -
van Drongelen V, Miglioranza Scavuzzi B, Holoshitz J. Rheumatology (Oxford), 2022 Mar 2; 61 (3): 889 - 891.Journal ArticleThe Cusp theory: is there more to HLA-disease association?
DOI:10.1093/rheumatology/keab624 PMID: 34436565 -
Scavuzzi BM, van Drongelen V, Holoshitz J. Front Immunol, 2022 13: 814967Journal ArticleHLA-G and the MHC Cusp Theory.
DOI:10.3389/fimmu.2022.814967 PMID: 35281038 -
Scavuzzi BM, Kaur B, Van Drongelen V, Mesquita-Ferrari R, Sawalha A, Miller F, Holoshitz J. ARTHRITIS & RHEUMATOLOGY, 2022 Nov; 74: 1338 - 1340.Proceeding / Abstract / PosterA Short Allelic Epitope Coded by HLA-DRB1*03:01 Activates a Systemic Lupus Erythematosus Cell Aberration Cascade
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van Drongelen V, Scavuzzi BM, Nogueira SV, Miller FW, Sawalha AH, Holoshitz J. Sci Rep, 2021 Jan 28; 11 (1): 2599Journal ArticleHLA-DRB1 allelic epitopes that associate with autoimmune disease risk or protection activate reciprocal macrophage polarization.
DOI:10.1038/s41598-021-82195-3 PMID: 33510427
