Edward T and Ellen K Dryer Early Career Professor of Rheumatology
Assistant Professor of Internal Medicine
[email protected]
Available to mentor
Yu Zuo
Assistant Professor
Dr. Zuo is the Edward T. and Ellen K. Dryer Early Career Professor of Rheumatology, Assistant Professor in the Department of Internal Medicine, and the Antiphospholipid Syndrome Program associate director at the University of Michigan. His research focuses on the pathogenic role of neutrophil extracellular traps (NETs) and autoimmunities against NETs in various thromboinflammatory diseases such as antiphospholipid syndrome (APS), vasculitis and COVID-19. He has authored more than 50 papers, and his current research is supported by the National Institute of Health, Taubman Medical Research Institute, Arthritis National Research Foundation, the National Institute of Health, the Rheumatology Research Foundation, and the Frankel Cardiovascular Center at the University of Michigan support his current research. He has earned the distinction of being named a Taubman Institute Emerging Scholar and was also the recipient of the 2024 American Society of Clinical Investigation Young Physician-Scientist Award.
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Center MemberTaubman Institute
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Center MemberSamuel and Jean Frankel Cardiovascular Center
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Casares-Marfil D, Martínez-Bueno M, Borghi MO, Pons-Estel G, PRECISESADS Clinical Consortium , Reales G, Zuo Y, Espinosa G, Radstake T, van den Hoogen LL, Wallace C, Guthridge J, James JA, Cervera R, Meroni PL, Martin J, Knight JS, Alarcón-Riquelme ME, Sawalha AH. Arthritis Rheumatol, 2024 Nov; 76 (11): 1623 - 1634.Journal ArticleA Genome-Wide Association Study Suggests New Susceptibility Loci for Primary Antiphospholipid Syndrome.
DOI:10.1002/art.42947 PMID: 38973605 -
Tambralli A, Harbaugh A, NaveenKumar SK, Radyk MD, Rysenga CE, Sabb K, Hurley JM, Sule GJ, Yalavarthi S, Estes SK, Hoy CK, Smith T, Sarosh C, Madison JA, Schaefer JK, Sood SL, Zuo Y, Sawalha AH, Lyssiotis CA, Knight JS. J Clin Invest, 2024 Jun 13; 134 (15):Journal ArticleNeutrophil glucose flux as a therapeutic target in antiphospholipid syndrome.
DOI:10.1172/JCI169893 PMID: 38869951 -
Sloan EE, Kmetova K, NaveenKumar SK, Kluge L, Chong E, Hoy CK, Yalavarthi S, Sarosh C, Baisch J, Walters L, Nassi L, Fuller J, Turnier JL, Pascual V, Wright TB, Madison JA, Knight JS, Zia A, Zuo Y. Clin Immunol, 2024 Apr; 261: 109926Journal ArticleNon-criteria antiphospholipid antibodies and calprotectin as potential biomarkers in pediatric antiphospholipid syndrome.
DOI:10.1016/j.clim.2024.109926 PMID: 38355030 -
Yelnik CM, Erton ZB, Drumez E, Cheildze D, de Andrade D, Clarke A, Tektonidou MG, Sciascia S, Pardos-Gea J, Pengo V, Ruiz-Irastorza G, Belmont HM, Pedrera CL, Fortin PR, Wahl D, Gerosa M, Kello N, Signorelli F, Atsumi T, Ji L, Efthymiou M, Branch DW, Nalli C, Rodriguez-Almaraz E, Petri M, Cervera R, Shi H, Zuo Y, Artim-Esen B, Pons-Estel G, Willis R, Barber MRW, Skeith L, Bertolaccini ML, Cohen H, Roubey R, Erkan D. Semin Arthritis Rheum, 2024 Apr; 65: 152347Journal ArticleThrombosis recurrence and major bleeding in non-anticoagulated thrombotic antiphospholipid syndrome patients: Prospective study from antiphospholipid syndrome alliance for clinical trials and international networking (APS ACTION) clinical database and repository ("Registry").
DOI:10.1016/j.semarthrit.2023.152347 PMID: 38185079 -
NaveenKumar SK, Tambralli A, Fonseca BM, Yalavarthi S, Liang W, Hoy CK, Sarosh C, Rysenga CE, Ranger CH, Vance CE, Madison JA, Orsi FA, Sood SL, Schaefer JK, Zuo Y, Knight JS. Blood, 2024 Mar 21; 143 (12): 1193 - 1197.Journal ArticleLow ectonucleotidase activity and increased neutrophil-platelet aggregates in patients with antiphospholipid syndrome.
DOI:10.1182/blood.2023022097 PMID: 38237140 -
Hoy CK, NaveenKumar SK, Navaz SA, Sugur K, Yalavarthi S, Sarosh C, Smith T, Kmetova K, Chong E, Peters NF, Rysenga CE, Norman GL, Figueroa-Parra G, Nelson D, Girard J, Ahmed AZ, Schaefer JK, Gudjonsson JE, Kahlenberg JM, Madison JA, Knight JS, Crowson CS, Duarte-García A, Zuo Y. Arthritis Rheumatol, 2024 Jun; 76 (6): 928 - 935.Journal ArticleCalprotectin Impairs Platelet Survival in Patients With Primary Antiphospholipid Syndrome.
DOI:10.1002/art.42801 PMID: 38225923 -
Casares-Marfil D, Martínez-Bueno M, Borghi MO, Pons-Estel G, PRECISESADS Clinical Consortium , Reales G, Zuo Y, Espinosa G, Radstake T, van den Hoogen LL, Wallace C, Guthridge J, James JA, Cervera R, Meroni PL, Martin J, Knight JS, Alarcón-Riquelme ME, Sawalha AH. 2023 Dec 5;PreprintA genome-wide association study suggests new susceptibility loci for primary antiphospholipid syndrome.
DOI:10.1101/2023.12.05.23299396 PMID: 38405993 -
Woodruff MC, Bonham KS, Anam FA, Walker TA, Faliti CE, Ishii Y, Kaminski CY, Ruunstrom MC, Cooper KR, Truong AD, Dixit AN, Han JE, Ramonell RP, Haddad NS, Rudolph ME, Yalavarthi S, Betin V, Natoli T, Navaz S, Jenks SA, Zuo Y, Knight JS, Khosroshahi A, Lee FE-H, Sanz I. Nat Commun, 2023 Jul 14; 14 (1): 4201Journal ArticleChronic inflammation, neutrophil activity, and autoreactivity splits long COVID.
DOI:10.1038/s41467-023-40012-7 PMID: 37452024
Department News
Congratulations to Dr. Yu (Ray) Zuo and Dr. Jacqueline Madison, recipients of annual Department of Internal Medicine and Department of Pediatrics education awards.
Research News
Dr. Yu (Ray) Zuo recently sat down with podcast host, Victoria Shanmugam, MBBS, MRCP, CCD, to discuss whether calprotectin can be a functional biomarker for those with APS thrombocytopenia and what the future holds for this study’s conclusions.
Research News
The APS Program Community Q&A Series, written by Yu (Ray) Zuo, MD, MSCS, was created to answer questions we receive from the APS Program community and covers a variety of topics. In this month’s edition, Dr. Zuo discusses how APS can impact your kidneys and the steps that you can take to keep your kidneys healthy.
