Chelsea Kaplan, PhD

Chelsea Kaplan
Research Assistant Professor
Anesthesiology
Medical School
[email protected]
Available to mentor
Chelsea Kaplan, PhD
Chelsea Kaplan
Research Assistant Professor
  • About
  • Links
  • Qualifications
  • Center Memberships
  • Research Overview
  • Recent Publications
  • Manage Your Profile

  • About

    Chelsea Kaplan is a Research Assistant Professor in the Department of Anesthesiology and the Director of Neuroimaging in the Chronic Pain and Fatigue Research Center (CPFRC). She completed her undergraduate degree in Brain, Behavior and Cognitive Science and received her doctorate in Neuroscience from the University of Michigan in 2018. Her graduate and postdoctoral training was completed at the CPFRC where she focused on examining the neurobiology of chronic pain using multimodal imaging techniques. Dr. Kaplan’s research includes investigating the central nervous system contributions to nociplastic pain across many conditions, identifying biomarkers that predict treatment outcomes, and examining the neural correlates of inflammation in rheumatic disease and nociplastic pain conditions. Her most recent work is focused on investigating behavioral and neurobiological factors associated with the development and trajectory of chronic pain in children. Understanding the neural vulnerability to pain may provide new insights about pain mechanisms, with the hope that identifying at-risk youth will enable early interventions that may alter the lifelong course of chronic pain.

    Links

    • Chronic Pain & Fatigue Research Center

    Qualifications

    • Research Fellow
      University of Michigan–Ann Arbor, T32, Ann Arbor, United States
      2020 - 2022
      Postdoctoral Research
    • Postdoctoral Researcher
      University of Michigan, USA
      2018 - 2022
      Postdoctoral Research
    • PhD
      University of Michigan, Ann Arbor, MI, United States
      2012 - 2018

    Center Memberships

    • Center Member
      Opioid Research Institute

    Research Overview

    • The neurobiological mechanisms underlying the development of chronic pain during childhood and adolescence
    • Identification of central nervous system biomarkers in nociplastic/centralized pain
    • The relationship between peripheral inflammation and brain function

    Recent Publications

    See All Publications
    • Journal Article
      Multimorbidity in Chronic Overlapping Pain Conditions: From Burden to Integrated Care
      d’Incau E, Kaplan CM, Micoulaud-Franchi J-A, Veasley C, Ohrbach R. Journal of Clinical Medicine, 2026 Jun 24; 15 (12): 4835 - 4835. DOI:10.3390/jcm15124835
    • Preprint
      Generalized Sensory Sensitivity for Prediction of Post-Surgical Analgesic Outcomes: An Observational Cohort Study of Total Hip Arthroplasty and Hysterectomy
      Schrepf A, Smith T, Waller N, Harris RE, Ichesco E, Kaplan CM, Till SR, Williams DA, As-Sanie S, Evanski JM, Urquhart A, Brummett CM, Clauw DJ, Harte SE. 2026 May 27; openRxiv, DOI:10.64898/2026.05.26.26354108
    • Journal Article
      Fatigue Links Sociodemographic Risk to Pain Intensity and Spread in Two Surgical Cohorts.
      Sun M, Ansari B, Clauw D, Harris RE, Sluka KA, Kaplan CM, Brummet CM, Lindquist MA, Wager TD, A2CPS Consortium . medRxiv, 2026 Feb 4; DOI:10.64898/2026.02.02.26345387
      PMID: PMC12889796
    • Journal Article
      A Comparison of Brain MRI Outcomes in Youth American Football versus Noncontact Sport Athletes.
      Ichesco E, Li Y, Shih C-H, Ichesco I, Almeida A, Varangis E, Schrepf A, Kaplan C, Popovich M, Peltier SJ, Harris RE, Lorincz MT, He X, Eckner J. Med Sci Sports Exerc, 2026 Feb 1; 58 (2): 261 - 270. DOI:10.1249/MSS.0000000000003856
      PMID: 41021925
    • Journal Article
      Central Nervous System Mechanisms and Treatment Response in Chronic Ocular Surface Pain: Protocol for a Cross-Sectional Observational Phenotyping Study.
      De Lott LB, Harte SE, Kaplan C, Williams DA, Shtein R, Woodward MA, Tsodikov A, Deveney T, Galor A, Shea A, Schultz C, McKolay C, Scott KA, Clauw DJ. JMIR Res Protoc, 2026 Jan 15; 15: e84240 DOI:10.2196/84240
      PMID: PMC12856401
    • Journal Article
      Research Review: On the (mis)use of puberty data in the ABCD Study® - a systematic review, problem illustration, and path forward.
      Beltz AM, Pham H, Smith T, Hidalgo-Lopez E, Becker H, Portengen CM, Heitzeg MM, Kaplan C, Berenbaum SA. J Child Psychol Psychiatry, 2026 Jan; 67 (1): 138 - 151. DOI:10.1111/jcpp.70035
      PMID: PMC12699133
    • Journal Article
      Visual hypersensitivity as a transdiagnostic marker of surgical pain response in arthritis and chronic pain syndromes.
      Waller N, Harte SE, Harris RE, Schrepf A, Smith T, Ichesco E, Kaplan C, Sunzini F, Minhas D, Marder W, Till SR, Williams DA, Brummett CM, Basu N, As-Sanie S, Clauw DJ. Arthritis Rheumatol, 2025 Dec 26; DOI:10.1002/art.70042
      PMID: 41451525
    • Journal Article
      Working memory and daily internalizing problems: Pubertal timing moderates adult relations.
      Chaku N, Yan R, Kaplan CM, Foster KT, Beltz AM. J Affect Disord, 2025 Dec 22; 121024 DOI:10.1016/j.jad.2025.121024
      PMID: 41443322

    Featured News & Stories

    Nociplastic pain researchers Chelsea Kaplan, Steven Harte, Andrew Schrepf, Dan Clauw
    Department News

    What we know about nociplastic pain

    A new review article shines light on nociplastic pain, a type of pain some thought to be ‘all in your head’
    Department News

    Fourteen faculty promotions announced

    The University of Michigan Regents approved 14 Department of Anesthesiology faculty promotions during their May 2023 meeting. Promotions will go into effect September 1.