Chelsea Kaplan, PhD

Chelsea Kaplan
Research Assistant Professor
Anesthesiology
Medical School
Email:
[email protected]
Available to mentor
Chelsea Kaplan, PhD
Chelsea Kaplan
Research Assistant Professor
  • About
  • Links
  • Qualifications
  • Center Memberships
  • Research Overview
  • Recent Publications
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  • About

    Chelsea Kaplan is a Research Assistant Professor in the Department of Anesthesiology and the Director of Neuroimaging in the Chronic Pain and Fatigue Research Center (CPFRC). She completed her undergraduate degree in Brain, Behavior and Cognitive Science and received her doctorate in Neuroscience from the University of Michigan in 2018. Her graduate and postdoctoral training was completed at the CPFRC where she focused on examining the neurobiology of chronic pain using multimodal imaging techniques. Dr. Kaplan’s research includes investigating the central nervous system contributions to nociplastic pain across many conditions, identifying biomarkers that predict treatment outcomes, and examining the neural correlates of inflammation in rheumatic disease and nociplastic pain conditions. Her most recent work is focused on investigating behavioral and neurobiological factors associated with the development and trajectory of chronic pain in children. Understanding the neural vulnerability to pain may provide new insights about pain mechanisms, with the hope that identifying at-risk youth will enable early interventions that may alter the lifelong course of chronic pain.

    Links

    • Chronic Pain & Fatigue Research Center

    Qualifications

    • Research Fellow
      University of Michigan–Ann Arbor, T32, Ann Arbor, United States
      2020 - 2022
      Postdoctoral Research
    • Postdoctoral Researcher
      University of Michigan, USA
      2018 - 2022
      Postdoctoral Research
    • PhD
      University of Michigan, Ann Arbor, MI, United States
      2012 - 2018

    Center Memberships

    • Center Member
      Opioid Research Institute

    Research Overview

    • The neurobiological mechanisms underlying the development of chronic pain during childhood and adolescence
    • Identification of central nervous system biomarkers in nociplastic/centralized pain
    • The relationship between peripheral inflammation and brain function

    Recent Publications

    See All Publications
    • Journal Article
      Cortical thickness, surface area, and multisite pain: distinct patterns by sex in adolescence
      Hidalgo-Lopez E, Portengen C, Smith T, Becker HC, Schrepf A, Harte SE, Beltz AM, Kaplan CM. Biology of Sex Differences, 2026 Dec 1; 17 (1): DOI:10.1186/s13293-026-00898-6
      PMID: 41943162
    • Journal Article
      Sex-specific developmental pathways link brain networks, sensory sensitivity, and sleep to adolescent pain
      Hidalgo-Lopez E, Portengen CM, Smith T, Angstadt M, Schrepf A, Clauw DJ, Harte SE, Heitzeg MM, Mindell JA, Beltz AM, Kaplan CM. Communications Biology, 2026 Jul 23; DOI:10.1038/s42003-026-10619-9
    • Preprint
      JAK-STAT pathway inhibition modulates centrally sensitised default mode network hubs in rheumatoid arthritis pain
      Stefanov K, Parkinson JT, Sunzini F, Al-Wasity S, Kaplan CM, Schrepf A, Ichesco E, Porter DA, Keith GA, McGucken A, Brock J, Aldehmi N, Paramo-Fiscal L, Tulunay-Virlan A, Arnott M, Lau T, Goodyear C, Thut G, Shenker N, McInnes IB, Clauw DJ, Cavangh J, Basu N. 2026 Jul 16; medRxiv, DOI:10.64898/2026.07.12.26356929
    • Journal Article
      Multimorbidity in Chronic Overlapping Pain Conditions: From Burden to Integrated Care
      d’Incau E, Kaplan CM, Micoulaud-Franchi J-A, Veasley C, Ohrbach R. Journal of Clinical Medicine, 2026 Jun 24; 15 (12): 4835 - 4835. DOI:10.3390/jcm15124835
    • Journal Article
      Youth experiences with discrimination and the association with multisite pain
      Malik M, Smith T, Clauw D, Nafiu OO, Bergmans RS, Kaplan C, Puglia MP. Pain Reports, 2026 Jun 1; 11 (3): DOI:10.1097/PR9.0000000000001432
    • Preprint
      Generalized Sensory Sensitivity for Prediction of Post-Surgical Analgesic Outcomes: An Observational Cohort Study of Total Hip Arthroplasty and Hysterectomy
      Schrepf A, Smith T, Waller N, Harris RE, Ichesco E, Kaplan CM, Till SR, Williams DA, As-Sanie S, Evanski JM, Urquhart A, Brummett CM, Clauw DJ, Harte SE. 2026 May 27; openRxiv, DOI:10.64898/2026.05.26.26354108
    • Proceeding / Abstract / Poster
      427 Endocannabinoids and pain: Exploring sex differences and pain risk factors in youth
      Evanski J, Kaplan CM, Harte SE. Journal of Clinical and Translational Science, 2026 May 9; 10 (s1): 136 - 136. DOI:10.1017/cts.2026.10576
      PMID: PMC13173239
    • Proceeding / Abstract / Poster
      10 Functional Connectivity Differences Underly Variable Centralized Symptom Relief After Hysterectomy
      McLain N, Kaplan C, Harte S, Clauw D, As-Sanie S, Schrepf A. Journal of Pain, 2026 Mar 26; 41: 105657 DOI:10.1016/j.jpain.2025.105657

    Featured News & Stories

    Nociplastic pain researchers Chelsea Kaplan, Steven Harte, Andrew Schrepf, Dan Clauw
    Department News

    What we know about nociplastic pain

    A new review article shines light on nociplastic pain, a type of pain some thought to be ‘all in your head’
    Department News

    Fourteen faculty promotions announced

    The University of Michigan Regents approved 14 Department of Anesthesiology faculty promotions during their May 2023 meeting. Promotions will go into effect September 1.