Chelsea Kaplan, PhD
Research Assistant Professor
[email protected]

Available to mentor

Chelsea Kaplan, PhD
Research Assistant Professor
  • About
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  • Qualifications
  • Research Overview
  • Recent Publications
  • About

    Chelsea Kaplan is a Research Assistant Professor in the Department of Anesthesiology and the Director of Neuroimaging in the Chronic Pain and Fatigue Research Center (CPFRC). She completed her undergraduate degree in Brain, Behavior and Cognitive Science and received her doctorate in Neuroscience from the University of Michigan in 2018. Her graduate and postdoctoral training was completed at the CPFRC where she focused on examining the neurobiology of chronic pain using multimodal imaging techniques. Dr. Kaplan’s research includes investigating the central nervous system contributions to nociplastic pain across many conditions, identifying biomarkers that predict treatment outcomes, and examining the neural correlates of inflammation in rheumatic disease and nociplastic pain conditions. Her most recent work is focused on investigating behavioral and neurobiological factors associated with the development and trajectory of chronic pain in children. Understanding the neural vulnerability to pain may provide new insights about pain mechanisms, with the hope that identifying at-risk youth will enable early interventions that may alter the lifelong course of chronic pain.

    • Chronic Pain & Fatigue Research Center
    • PhD
      University of Michigan, Ann Arbor, 2018
    Research Overview

    • The neurobiological mechanisms underlying the development of chronic pain during childhood and adolescence
    • Identification of central nervous system biomarkers in nociplastic/centralized pain
    • The relationship between peripheral inflammation and brain function

    Recent Publications See All Publications
    • Journal Article
      Broadening the Scope of Resilience in Chronic Pain: Methods, Social Context, and Development.
      Sturgeon JD, Zubieta C, Kaplan CM, Pierce J, Arewasikporn A, Slepian PM, Hassett AL, Trost Z. Current Rheumatology Reviews, 2024 Jan;
    • Journal Article
      Large-scale momentary brain co-activation patterns are associated with hyperalgesia and mediate focal neurochemistry and cross-network functional connectivity in fibromyalgia.
      Mawla I, Huang Z, Kaplan CM, Ichesco E, Waller N, Larkin TE, Zöllner HJ, Edden RAE, Harte SE, Clauw DJ, Mashour GA, Napadow V, Harris RE. Pain, 2023 Dec 1; 164 (12): 2737 - 2748. DOI:10.1097/j.pain.0000000000002973
      PMID: 37751539
    • Journal Article
      Risk Factors for the Development of Multisite Pain in Children.
      Kaplan CM, Schrepf A, Boehnke KF, He Y, Smith T, Williams DA, Bergmans R, Voepel-Lewis T, Hassett AL, Harris RE, Clauw DJ, Beltz AM, Harte SE. Clin J Pain, 2023 Nov 1; 39 (11): 588 - 594. DOI:10.1097/AJP.0000000000001148
      PMID: 37440345
    • Journal Article
      An Interventional Response Phenotyping Study in Chronic Low Back Pain: Protocol for a Mechanistic Randomized Controlled Trial.
      Hassett AL, Williams DA, Harris RE, Harte SE, Kaplan CM, Schrepf A, Kratz AL, Brummett CM, Kidwell KM, Tsodikov A, Shaikh S, Murphy SL, Lobo R, King A, Favorite T, Fisher L, Golmirzaie GM, Kohns DJ, Schneiderhan JR, Mawla I, Ichesco E, McAfee J, Wasserman RA, Banner E, Scott KA, Cole C, Clauw DJ. Pain Med, 2023 Aug 4; 24 (Suppl 1): S126 - S138. DOI:10.1093/pm/pnad005
      PMID: 36708026
    • Journal Article
      Fibromyalgia predicts increased odds of pain-related addiction exacerbation among individuals with pain and opioid use disorder.
      Hall OT, Teater J, Entrup P, Deaner M, Bryan C, Harte SE, Kaplan CM, Phan KL, Clauw DJ. Pain, 2023 Aug 1; 164 (8): 1801 - 1809. DOI:10.1097/j.pain.0000000000002878
      PMID: 36921216
    • Journal Article
      Functional Magnetic Resonance Imaging Signal Variability Is Associated With Neuromodulation in Fibromyalgia.
      Lim M, Kim DJ, Nascimento TD, Ichesco E, Kaplan C, Harris RE, DaSilva AF. Neuromodulation, 2023 Jul; 26 (5): 999 - 1008. DOI:10.1111/ner.13512
      PMID: 34309138
    • Journal Article
      Hypothetical model ignores many important pathophysiologic mechanisms in fibromyalgia.
      Clauw DJ, Choy EHS, Napadow V, Soni A, Boehnke KF, Naliboff B, Hassett AL, Arewasikporn A, Schrepf A, Kaplan CM, Williams D, Basu N, Bergmans RS, Harris RE, Harte SE, Chadwick A, Macfarlane GJ. Nat Rev Rheumatol, 2023 May; 19 (5): 321 DOI:10.1038/s41584-023-00951-3
      PMID: 36964334
    • Journal Article
      Stimulated whole-blood cytokine/chemokine responses are associated with interstitial cystitis/bladder pain syndrome phenotypes and features of nociplastic pain: a multidisciplinary approach to the study of chronic pelvic pain research network study.
      Schrepf A, Kaplan C, Harris RE, Williams DA, Clauw DJ, As-Sanie S, Till S, Clemens JQ, Rodriguez LV, Van Bokhoven A, Landis R, Gallop R, Bradley C, Naliboff B, Pontari M, O'Donnell M, Luo Y, Kreder K, Lutgendorf SK, Harte SE. Pain, 2023 May 1; 164 (5): 1148 - 1157. DOI:10.1097/j.pain.0000000000002813
      PMID: 36279178
    Featured News & Stories
    Department News
    Fourteen faculty promotions announced
    The University of Michigan Regents approved 14 Department of Anesthesiology faculty promotions during their May 2023 meeting. Promotions will go into effect September 1.