Chelsea Kaplan, PhD
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About
Chelsea Kaplan is a Research Assistant Professor in the Department of Anesthesiology and the Director of Neuroimaging in the Chronic Pain and Fatigue Research Center (CPFRC). She completed her undergraduate degree in Brain, Behavior and Cognitive Science and received her doctorate in Neuroscience from the University of Michigan in 2018. Her graduate and postdoctoral training was completed at the CPFRC where she focused on examining the neurobiology of chronic pain using multimodal imaging techniques. Dr. Kaplan’s research includes investigating the central nervous system contributions to nociplastic pain across many conditions, identifying biomarkers that predict treatment outcomes, and examining the neural correlates of inflammation in rheumatic disease and nociplastic pain conditions. Her most recent work is focused on investigating behavioral and neurobiological factors associated with the development and trajectory of chronic pain in children. Understanding the neural vulnerability to pain may provide new insights about pain mechanisms, with the hope that identifying at-risk youth will enable early interventions that may alter the lifelong course of chronic pain.
Links
Chronic Pain & Fatigue Research Center
Qualifications
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Research FellowUniversity of Michigan–Ann Arbor, T32, Ann Arbor, United States
2020 - 2022
Postdoctoral Research
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Postdoctoral ResearcherUniversity of Michigan, USA
2018 - 2022
Postdoctoral Research
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PhDUniversity of Michigan, Ann Arbor, MI, United States
2012 - 2018
Center Memberships
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Center MemberOpioid Research Institute
Research Overview
• The neurobiological mechanisms underlying the development of chronic pain during childhood and adolescence
• Identification of central nervous system biomarkers in nociplastic/centralized pain
• The relationship between peripheral inflammation and brain function
Recent Publications
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d’Incau E, Kaplan CM, Micoulaud-Franchi J-A, Veasley C, Ohrbach R. Journal of Clinical Medicine, 2026 Jun 24; 15 (12): 4835 - 4835.Journal ArticleMultimorbidity in Chronic Overlapping Pain Conditions: From Burden to Integrated Care
DOI:10.3390/jcm15124835 -
Schrepf A, Smith T, Waller N, Harris RE, Ichesco E, Kaplan CM, Till SR, Williams DA, As-Sanie S, Evanski JM, Urquhart A, Brummett CM, Clauw DJ, Harte SE. 2026 May 27; openRxiv,PreprintGeneralized Sensory Sensitivity for Prediction of Post-Surgical Analgesic Outcomes: An Observational Cohort Study of Total Hip Arthroplasty and Hysterectomy
DOI:10.64898/2026.05.26.26354108 -
Sun M, Ansari B, Clauw D, Harris RE, Sluka KA, Kaplan CM, Brummet CM, Lindquist MA, Wager TD, A2CPS Consortium . medRxiv, 2026 Feb 4;Journal ArticleFatigue Links Sociodemographic Risk to Pain Intensity and Spread in Two Surgical Cohorts.
DOI:10.64898/2026.02.02.26345387 PMID: PMC12889796 -
Ichesco E, Li Y, Shih C-H, Ichesco I, Almeida A, Varangis E, Schrepf A, Kaplan C, Popovich M, Peltier SJ, Harris RE, Lorincz MT, He X, Eckner J. Med Sci Sports Exerc, 2026 Feb 1; 58 (2): 261 - 270.Journal ArticleA Comparison of Brain MRI Outcomes in Youth American Football versus Noncontact Sport Athletes.
DOI:10.1249/MSS.0000000000003856 PMID: 41021925 -
De Lott LB, Harte SE, Kaplan C, Williams DA, Shtein R, Woodward MA, Tsodikov A, Deveney T, Galor A, Shea A, Schultz C, McKolay C, Scott KA, Clauw DJ. JMIR Res Protoc, 2026 Jan 15; 15: e84240Journal ArticleCentral Nervous System Mechanisms and Treatment Response in Chronic Ocular Surface Pain: Protocol for a Cross-Sectional Observational Phenotyping Study.
DOI:10.2196/84240 PMID: PMC12856401 -
Beltz AM, Pham H, Smith T, Hidalgo-Lopez E, Becker H, Portengen CM, Heitzeg MM, Kaplan C, Berenbaum SA. J Child Psychol Psychiatry, 2026 Jan; 67 (1): 138 - 151.Journal ArticleResearch Review: On the (mis)use of puberty data in the ABCD Study® - a systematic review, problem illustration, and path forward.
DOI:10.1111/jcpp.70035 PMID: PMC12699133 -
Waller N, Harte SE, Harris RE, Schrepf A, Smith T, Ichesco E, Kaplan C, Sunzini F, Minhas D, Marder W, Till SR, Williams DA, Brummett CM, Basu N, As-Sanie S, Clauw DJ. Arthritis Rheumatol, 2025 Dec 26;Journal ArticleVisual hypersensitivity as a transdiagnostic marker of surgical pain response in arthritis and chronic pain syndromes.
DOI:10.1002/art.70042 PMID: 41451525 -
Chaku N, Yan R, Kaplan CM, Foster KT, Beltz AM. J Affect Disord, 2025 Dec 22; 121024Journal ArticleWorking memory and daily internalizing problems: Pubertal timing moderates adult relations.
DOI:10.1016/j.jad.2025.121024 PMID: 41443322
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