Chelsea Kaplan, PhD
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About
Chelsea Kaplan is a Research Assistant Professor in the Department of Anesthesiology and the Director of Neuroimaging in the Chronic Pain and Fatigue Research Center (CPFRC). She completed her undergraduate degree in Brain, Behavior and Cognitive Science and received her doctorate in Neuroscience from the University of Michigan in 2018. Her graduate and postdoctoral training was completed at the CPFRC where she focused on examining the neurobiology of chronic pain using multimodal imaging techniques. Dr. Kaplan’s research includes investigating the central nervous system contributions to nociplastic pain across many conditions, identifying biomarkers that predict treatment outcomes, and examining the neural correlates of inflammation in rheumatic disease and nociplastic pain conditions. Her most recent work is focused on investigating behavioral and neurobiological factors associated with the development and trajectory of chronic pain in children. Understanding the neural vulnerability to pain may provide new insights about pain mechanisms, with the hope that identifying at-risk youth will enable early interventions that may alter the lifelong course of chronic pain.
Links
Chronic Pain & Fatigue Research Center
Qualifications
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Research FellowUniversity of Michigan–Ann Arbor, T32, Ann Arbor, United States
2020 - 2022
Postdoctoral Research
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Postdoctoral ResearcherUniversity of Michigan, USA
2018 - 2022
Postdoctoral Research
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PhD, NeuroscienceUniversity of Michigan, Ann Arbor, MI, United States
2012 - 2018
Center Memberships
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Center MemberOpioid Research Institute
Research Overview
• The neurobiological mechanisms underlying the development of chronic pain during childhood and adolescence
• Identification of central nervous system biomarkers in nociplastic/centralized pain
• The relationship between peripheral inflammation and brain function
Recent Publications
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Hidalgo-Lopez E, Portengen C, Smith T, Becker HC, Schrepf A, Harte SE, Beltz AM, Kaplan CM. Biology of Sex Differences, 2026 Dec 1; 17 (1):Journal ArticleCortical thickness, surface area, and multisite pain: distinct patterns by sex in adolescence
DOI:10.1186/s13293-026-00898-6 PMID: 41943162 -
McLain N, Kaplan C, Harte S, Lenert M, Evanski J, Hidalgo-Lopez E, Egan M, Ichesco E, Harris RE, Kutch J, Clauw D, As-Sanie S, Schrepf A. 2026 Sep 30; openRxiv,PreprintFunctional Connectivity Differences Underly Variable Centralized Symptom Relief After Hysterectomy
DOI:10.64898/2026.09.26.754679 -
McLain N, Kaplan C, Harte S, Schrepf A. 2026 Sep 25;PreprintConcordance between the fast and efficient mixed-effects algorithm (FEMA) and conventional mixed-effects modeling for whole-brain connectivity in longitudinal chronic pain.
DOI:10.64898/2026.09.20.753017 PMID: 42818179 -
McLain NJ, Kaplan CM, Naliboff BD, Rodriguez L, Moldwin R, Williams DA, Farrar JT, Harris RE, Spitznagle T, Clauw D, Clemens JQ, Harte SE, Kutch JJ, Schrepf A. Pain, 2026 Sep 29;Journal ArticleDistinct connectivity patterns subserve 2 dimensions of the chronic pain experience
DOI:10.1097/j.pain.0000000000004114 -
Hidalgo-Lopez E, Portengen CM, Smith T, Angstadt M, Schrepf A, Clauw DJ, Harte SE, Heitzeg MM, Mindell JA, Beltz AM, Kaplan CM. Communications Biology, 2026 Jul 23;Journal ArticleSex-specific developmental pathways link brain networks, sensory sensitivity, and sleep to adolescent pain
DOI:10.1038/s42003-026-10619-9 -
Stefanov K, Parkinson JT, Sunzini F, Al-Wasity S, Kaplan CM, Schrepf A, Ichesco E, Porter DA, Keith GA, McGucken A, Brock J, Aldehmi N, Paramo-Fiscal L, Tulunay-Virlan A, Arnott M, Lau T, Goodyear C, Thut G, Shenker N, McInnes IB, Clauw DJ, Cavangh J, Basu N. 2026 Jul 16; medRxiv,PreprintJAK-STAT pathway inhibition modulates centrally sensitised default mode network hubs in rheumatoid arthritis pain
DOI:10.64898/2026.07.12.26356929 -
d’Incau E, Kaplan CM, Micoulaud-Franchi J-A, Veasley C, Ohrbach R. Journal of Clinical Medicine, 2026 Jun 24; 15 (12): 4835 - 4835.Journal ArticleMultimorbidity in Chronic Overlapping Pain Conditions: From Burden to Integrated Care
DOI:10.3390/jcm15124835 -
Waller N, Harte SE, Harris RE, Schrepf A, Smith T, Ichesco E, Kaplan C, Sunzini F, Minhas D, Marder W, Till SR, Williams DA, Brummett CM, Basu N, As-Sanie S, Clauw DJ. Arthritis Rheumatol, 2026 Jun; 78 (6): 1339 - 1349.Journal ArticleVisual Hypersensitivity as a Transdiagnostic Marker of Surgical Pain Response in Arthritis and Chronic Pain Syndromes.
DOI:10.1002/art.70042 PMID: PMC12910465
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