Chelsea Kaplan, PhD
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About
Chelsea Kaplan is a Research Assistant Professor in the Department of Anesthesiology and the Director of Neuroimaging in the Chronic Pain and Fatigue Research Center (CPFRC). She completed her undergraduate degree in Brain, Behavior and Cognitive Science and received her doctorate in Neuroscience from the University of Michigan in 2018. Her graduate and postdoctoral training was completed at the CPFRC where she focused on examining the neurobiology of chronic pain using multimodal imaging techniques. Dr. Kaplan’s research includes investigating the central nervous system contributions to nociplastic pain across many conditions, identifying biomarkers that predict treatment outcomes, and examining the neural correlates of inflammation in rheumatic disease and nociplastic pain conditions. Her most recent work is focused on investigating behavioral and neurobiological factors associated with the development and trajectory of chronic pain in children. Understanding the neural vulnerability to pain may provide new insights about pain mechanisms, with the hope that identifying at-risk youth will enable early interventions that may alter the lifelong course of chronic pain.
Links
Chronic Pain & Fatigue Research Center
Qualifications
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Research FellowUniversity of Michigan–Ann Arbor, T32, Ann Arbor, United States
2020 - 2022
Postdoctoral Research
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Postdoctoral ResearcherUniversity of Michigan, USA
2018 - 2022
Postdoctoral Research
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PhDUniversity of Michigan, Ann Arbor, MI, United States
2012 - 2018
Center Memberships
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Center MemberOpioid Research Institute
Research Overview
• The neurobiological mechanisms underlying the development of chronic pain during childhood and adolescence
• Identification of central nervous system biomarkers in nociplastic/centralized pain
• The relationship between peripheral inflammation and brain function
Recent Publications
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Hidalgo-Lopez E, Portengen C, Smith T, Becker HC, Schrepf A, Harte SE, Beltz AM, Kaplan CM. Biology of Sex Differences, 2026 Dec 1; 17 (1):Journal ArticleCortical thickness, surface area, and multisite pain: distinct patterns by sex in adolescence
DOI:10.1186/s13293-026-00898-6 PMID: 41943162 -
Hidalgo-Lopez E, Portengen CM, Smith T, Angstadt M, Schrepf A, Clauw DJ, Harte SE, Heitzeg MM, Mindell JA, Beltz AM, Kaplan CM. Communications Biology, 2026 Jul 23;Journal ArticleSex-specific developmental pathways link brain networks, sensory sensitivity, and sleep to adolescent pain
DOI:10.1038/s42003-026-10619-9 -
Stefanov K, Parkinson JT, Sunzini F, Al-Wasity S, Kaplan CM, Schrepf A, Ichesco E, Porter DA, Keith GA, McGucken A, Brock J, Aldehmi N, Paramo-Fiscal L, Tulunay-Virlan A, Arnott M, Lau T, Goodyear C, Thut G, Shenker N, McInnes IB, Clauw DJ, Cavangh J, Basu N. 2026 Jul 16; medRxiv,PreprintJAK-STAT pathway inhibition modulates centrally sensitised default mode network hubs in rheumatoid arthritis pain
DOI:10.64898/2026.07.12.26356929 -
d’Incau E, Kaplan CM, Micoulaud-Franchi J-A, Veasley C, Ohrbach R. Journal of Clinical Medicine, 2026 Jun 24; 15 (12): 4835 - 4835.Journal ArticleMultimorbidity in Chronic Overlapping Pain Conditions: From Burden to Integrated Care
DOI:10.3390/jcm15124835 -
Malik M, Smith T, Clauw D, Nafiu OO, Bergmans RS, Kaplan C, Puglia MP. Pain Reports, 2026 Jun 1; 11 (3):Journal ArticleYouth experiences with discrimination and the association with multisite pain
DOI:10.1097/PR9.0000000000001432 -
Schrepf A, Smith T, Waller N, Harris RE, Ichesco E, Kaplan CM, Till SR, Williams DA, As-Sanie S, Evanski JM, Urquhart A, Brummett CM, Clauw DJ, Harte SE. 2026 May 27; openRxiv,PreprintGeneralized Sensory Sensitivity for Prediction of Post-Surgical Analgesic Outcomes: An Observational Cohort Study of Total Hip Arthroplasty and Hysterectomy
DOI:10.64898/2026.05.26.26354108 -
Evanski J, Kaplan CM, Harte SE. Journal of Clinical and Translational Science, 2026 May 9; 10 (s1): 136 - 136.Proceeding / Abstract / Poster427 Endocannabinoids and pain: Exploring sex differences and pain risk factors in youth
DOI:10.1017/cts.2026.10576 PMID: PMC13173239 -
McLain N, Kaplan C, Harte S, Clauw D, As-Sanie S, Schrepf A. Journal of Pain, 2026 Mar 26; 41: 105657Proceeding / Abstract / Poster10 Functional Connectivity Differences Underly Variable Centralized Symptom Relief After Hysterectomy
DOI:10.1016/j.jpain.2025.105657
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