Available to mentor
I am a research assistant professor (2018+) whose interests rest at the intersection of psychiatry and epidemiology. My present work focuses, principally, on leveraging population-level data to answer mechanistic questions pertaining to the transmission and maintenance of psychiatric disorders. I hold a Master’s in research methods from the University of Oxford, and a PhD in psychiatric epidemiology from the Institute of Psychiatry, Psychology & Neuroscience (IOPPN) at King’s College London – the largest dedicated psychiatric research institute in Europe. Since completion of my PhD, I have been affiliated with the Karolinska Institute, where I have undertaken large-scale epidemiological investigations of familial transmission dynamics in psychiatric populations. The compelling results of these investigations spurred a program of research, with independent funding from the Brain and Behaviour Foundation, National Institute of Mental Health, and Eunice Kennedy Shriver National Institute of Child Health and Human Development, among others.
My current work focuses on leveraging the concentrated risk present in dual-affected families to inform mechanisms of intergenerational risk transmission. This work, while focused on mental health, also extends to questions of social drift and disadvantage in the context of psychiatric disorders, and integrates epidemiological and molecular genetic methods to directly inform and support improved care for families. My interdisciplinary approach brings together the large-scale, longitudinal data and mechanistically-informative analyses needed to delve into the complex risk dynamics inherent to high-risk population, and aims to providing concrete and actionable insights into the etiology of cross-generational burden of psychiatric disorders.
Recently, I have joined the Michigan Institute for Clinical and Health Research in the role of Senior Science Writer. Within MICHR, I will be assisting in developing, and thereafter enacting, a dissemination strategy for work occurring in the context of the Institute's recently-renewed ($71 m) Clinical Translational Science Award.
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Post-Doctoral ResearcherKarolinska Institute, CNS, 2018
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Post-Doctoral ResearcherImperial College London, School of Public Health, 2017
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Doctor of Philosophy (PhD)King's College London, London, 2014
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Master of Science (MSc)University of Oxford, Oxford, 2007
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Bachelor of Arts (BA) with HonorsUniversity of St. Thomas, St. Paul, 2006
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Center MemberInstitute for Healthcare Policy and Innovation
epidemiology; health equity; population health; transmission dynamics; mental health; familial risk; psychiatric liability; early intervention; anxiety; depression; bipolar disorder; schizophrenia; substance abuse; ADHD; ASD; OCD and related disorders
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Smolen C, Jensen M, Dyer L, Pizzo L, Tyryshkina A, Banerjee D, Rohan L, Huber E, El Khattabi L, Prontera P, Caberg J-H, Van Dijck A, Schwartz C, Faivre L, Callier P, Mosca-Boidron A-L, Lefebvre M, Pope K, Snell P, Lockhart PJ, Castiglia L, Galesi O, Avola E, Mattina T, Fichera M, Luana Mandarà GM, Bruccheri MG, Pichon O, Le Caignec C, Stoeva R, Cuinat S, Mercier S, Bénéteau C, Blesson S, Nordsletten A, Martin-Coignard D, Sistermans E, Kooy RF, Amor DJ, Romano C, Isidor B, Juusola J, Girirajan S. Am J Hum Genet, 2023 Dec 7; 110 (12): 2015 - 2028.Journal ArticleAssortative mating and parental genetic relatedness contribute to the pathogenicity of variably expressive variants.
DOI:10.1016/j.ajhg.2023.10.015 PMID: 37979581 -
Jain P, Miller-Fleming T, Topaloudi A, Yu D, Drineas P, Georgitsi M, Yang Z, Rizzo R, Müller-Vahl KR, Tumer Z, Mol Debes N, Hartmann A, Depienne C, Worbe Y, Mir P, Cath DC, Boomsma DI, Roessner V, Wolanczyk T, Janik P, Szejko N, Zekanowski C, Barta C, Nemoda Z, Tarnok Z, Buxbaum JD, Grice D, Glennon J, Stefansson H, Hengerer B, Benaroya-Milshtein N, Cardona F, Hedderly T, Heyman I, Huyser C, Morer A, Mueller N, Munchau A, Plessen KJ, Porcelli C, Walitza S, Schrag A, Martino D, Psychiatric Genomics Consortium Tourette Syndrome Working Group (PGC-TS) , EMTICS collaborative group , Dietrich A, TS-EUROTRAIN Network , Mathews CA, Scharf JM, Hoekstra PJ, Davis LK, Paschou P. Transl Psychiatry, 2023 Feb 23; 13 (1): 69Journal ArticlePolygenic risk score-based phenome-wide association study identifies novel associations for Tourette syndrome.
DOI:10.1038/s41398-023-02341-5 PMID: 36823209 -
Silhol R, Nordsletten A, Maheu-Giroux M, Elmes J, Staunton R, Owen B, Shacklett B, McGowan I, Feliciano KG, van der Straten A, Eller LA, Robb M, Marrazzo J, Dimitrov D, Boily M-C. AIDS Behav, 2023 Dec; 27 (12): 4010 - 4021.Journal ArticleThe Association Between Heterosexual anal Intercourse and HIV Acquisition in Three Prospective Cohorts of Women.
DOI:10.1007/s10461-023-04115-y PMID: 37392271 -
Sidorchuk A, Brander G, Pérez-Vigil A, Crowley JJ, Larsson H, Lichtenstein P, Mataix-Cols D, Nordsletten AE. Psychol Med, 2023 Nov; 53 (15): 7025 - 7041.Journal ArticleOne versus two biological parents with mental disorders: Relationship to educational attainment in the next generation.
DOI:10.1017/S0033291722003506 PMID: 36545765 -
Nordsletten AE, Isomura K, Crowley JJ, Cervin M, Larsson H, Lichtenstein P, Mataix-Cols D, Sidorchuk A. World Psychiatry, 2023 Oct; 22 (3): 483 - 484.Journal ArticleLabour market marginalization in children of persons with major psychiatric disorders: a Swedish national cohort study.
DOI:10.1002/wps.21127 PMID: 37713580 -
Smolen C, Jensen M, Dyer L, Pizzo L, Tyryshkina A, Banerjee D, Rohan L, Huber E, El Khattabi L, Prontera P, Caberg J-H, Van Dijck A, Schwartz C, Faivre L, Callier P, Mosca-Boidron A-L, Lefebvre M, Pope K, Snell P, Lockhart PJ, Castiglia L, Galesi O, Avola E, Mattina T, Fichera M, Mandarà GML, Bruccheri MG, Pichon O, Le Caignec C, Stoeva R, Cuinat S, Mercier S, Bénéteau C, Blesson S, Nordsletten A, Martin-Coignard D, Sistermans E, Kooy RF, Amor DJ, Romano C, Isidor B, Juusola J, Girirajan S. 2023 May 26;PreprintAssortative mating and parental genetic relatedness drive the pathogenicity of variably expressive variants.
DOI:10.1101/2023.05.18.23290169 PMID: 37292616 -
Rana GS, Nordsletten A, Sivananthan M, Hong V. Clin Child Psychol Psychiatry, 2023 Jan; 28 (1): 367 - 381.Journal ArticleA 6-year retrospective review of psychiatric emergency service utilization by school-age children.
DOI:10.1177/13591045211070924 PMID: 35594032 -
Silhol R, Nordsletten A, Maheu-Giroux M, Elmes J, Staunton R, Owen B, Shacklett B, McGowan I, Feliciano KG, van der Straten A, Eller LA, Robb M, Marrazzo J, Dimitrov D, Boily M-C. medRxiv,PreprintThe association between heterosexual anal intercourse and HIV acquisition in three prospective cohorts of women
DOI:10.1101/2022.09.07.22279674