1150 West Medical Center Dr
Ann Arbor, MI 48109
Available to mentor
Dr. Christiane Wobus is an Associate Professor in the Department of Microbiology and Immunology at the University of Michigan Medical School. She joined the department in 2007 and was subsequently promoted to Associate Professor in 2014. In 2014, she was also awarded the Friedrich Wilhelm Bessel Research Award from the Humboldt Foundation in Germany. Before joining the University of Michigan, Dr. Wobus was a postdoctoral fellow at Washington University in St. Louis, MO, where she co-discovered murine norovirus and subsequently developed the first cell culture system for noroviruses. She received her undergraduate training in Germany before moving to Michigan State University, East Lansing, MI, where she obtained her M.Sc. in 1997 studying the plant virus pea enation mosaic virus. She then returned to Germany for her doctoral studies on adeno-associated viruses at the German Cancer Research Institute, Heidelberg, and obtained her Ph.D. degree in 2000. Currently, Dr. Wobus’ research focuses on norovirus and astrovirus – host interactions. Her long-term goal is to identify conserved features between enteric viruses and across species that may ultimately lead to the development of effective prevention and control strategies for human noroviruses and astroviruses, major causes of non-bacterial gastroenteritis worldwide. During the COVID pandemic, her lab also engaged in collaborative studies investigating SARS-CoV-2. At the national and international level, Dr. Wobus is an editor for Journal of Virology and Journal of General Virology, and an associate editor for PLoS Pathogens. She currently is the chair of the American Society of Virology Travel Award committee and the University of Michigan Institutional Biosafety Committee.
Lab website Department Website
-
postdoctoral trainingWashington University in St. Louis School of Medicine, Pathology and Immunology, 2007
-
PhDGerman Cancer Research Institute, Heidelberg, 2000
-
MSMichigan State University, East Lansing, 1997
-
BSUniversity of Göttingen, Göttingen, 1994
The Wobus lab is interested in mechanisms of norovirus and astrovirus - host interactions. Noroviruses and astroviruses are major causes of viral gastroenteritis worldwide resulting in substantial morbidity and economic loss. However, little information is available about the biology of these viruses and no directed disease prevention and control strategies exist. With our discovery of the first murine norovirus (MNV-1) and hence the availability of a small animal model, the development of the first in vitro culture system and reverse genetics system for a norovirus, we have a unique system to undertake a detailed analysis of different aspects of norovirus biology. More recently, we have expanded our studies to human intestinal organoid systems to study human noroviruses and human astroviruses to compare and contrast human vs murine noroviruses and define shared features of enteric viruses, respectively. Since the start of the COVID-19 pandemic, we have also been performing collaborative studies with infectious SARS-CoV-2 at BSL3.
-
Atochina-Vasserman EN, Lindesmith LC, Mirabelli C, Ona NA, Reagan EK, Brewer-Jensen PD, Mercado-Lopez X, Shahnawaz H, Meshanni JA, Baboo I, Mallory ML, Zweigart MR, May SR, Mui BL, Tam YK, Wobus CE, Baric RS, Weissman D. NPJ Vaccines, 2024 Oct 1; 9 (1): 182Journal ArticleBivalent norovirus mRNA vaccine elicits cellular and humoral responses protecting human enteroids from GII.4 infection.
DOI:10.1038/s41541-024-00976-z PMID: 39353926 -
Hafner A, Meurs N, Garner A, Azar E, Kannan A, Passalacqua KD, Nagrath D, Wobus CE. PLoS Pathog, 2024 Jul; 20 (7): e1011909Journal ArticleNorovirus NS1/2 protein increases glutaminolysis for efficient viral replication.
DOI:10.1371/journal.ppat.1011909 PMID: 38976719 -
Li J, de Melo Jorge DM, Wang W, Sun S, Frum T, Hang Y-A, Liu Y, Zhou X, Xiao J, Wang X, Spence JR, Wobus CE, Zhu H-J. J Med Chem, 2024 May 9; 67 (9): 7470 - 7486.Journal ArticleDifferential Bioactivation Profiles of Different GS-441524 Prodrugs in Cell and Mouse Models: ProTide Prodrugs with High Cell Permeability and Susceptibility to Cathepsin A Are More Efficient in Delivering Antiviral Active Metabolites to the Lung.
DOI:10.1021/acs.jmedchem.4c00234 PMID: 38690769 -
Rasmussen AL, Gronvall GK, Lowen AC, Goodrum F, Alwine J, Andersen KG, Anthony SJ, Baines J, Banerjee A, Broadbent AJ, Brooke CB, Campos SK, Caposio P, Casadevall A, Chan GC, Cliffe AR, Collins-McMillen D, Connell N, Damania B, Daugherty MD, Debbink K, Dermody TS, DiMaio D, Duprex WP, Emerman M, Galloway DA, Garry RF, Goldstein SA, Greninger AL, Hartman AL, Hogue BG, Horner SM, Hotez PJ, Jung JU, Kamil JP, Karst SM, Laimins L, Lakdawala SS, Landais I, Letko M, Lindenbach B, Liu S-L, Luftig M, McFadden G, Mehle A, Morrison J, Moscona A, Mühlberger E, Munger J, Münger K, Murphy E, Neufeldt CJ, Nikolich JZ, O'Connor CM, Pekosz A, Permar SR, Pfeiffer JK, Popescu SV, Purdy JG, Racaniello VR, Rice CM, Runstadler JA, Sapp MJ, Scott RS, Smith GA, Sorrell EM, Speranza E, Streblow D, Tibbetts SA, Toth Z, Van Doorslaer K, Weiss SR, White EA, White TM, Wobus CE, Worobey M, Yamaoka S, Yurochko A. J Virol, 2024 Mar 19; 98 (3): e0007424Journal ArticleCorrection for Rasmussen et al., "Virology-the path forward".
DOI:10.1128/jvi.00074-24 PMID: 38334328 -
Sherman M, Cox F, Smith H, Habib MH, Karst S, Wobus CE, Smith TJ. J Virol, 2024 Feb 20; 98 (2): e0173523Journal ArticleThe reversible activation of norovirus by metal ions.
DOI:10.1128/jvi.01735-23 PMID: 38236007 -
Rasmussen AL, Gronvall GK, Lowen AC, Goodrum F, Alwine J, Andersen KG, Anthony SJ, Baines J, Banerjee A, Broadbent AJ, Brooke CB, Campos SK, Caposio P, Casadevall A, Chan GC, Cliffe AR, Collins-McMillen D, Connell N, Damania B, Daugherty MD, Debbink K, Dermody TS, DiMaio D, Duprex WP, Emerman M, Galloway DA, Garry RF, Goldstein SA, Greninger AL, Hartman AL, Hogue BG, Horner SM, Hotez PJ, Jung JU, Kamil JP, Karst SM, Laimins L, Lakdawala SS, Landais I, Letko M, Lindenbach B, Liu S-L, Luftig M, McFadden G, Mehle A, Morrison J, Moscona A, Mühlberger E, Munger J, Münger K, Murphy E, Neufeldt CJ, Nikolich JZ, O'Connor CM, Pekosz A, Permar SR, Pfeiffer JK, Popescu SV, Purdy JG, Racaniello VR, Rice CM, Runstadler JA, Sapp MJ, Scott RS, Smith GA, Sorrell EM, Speranza E, Streblow D, Tibbetts SA, Toth Z, Van Doorslaer K, Weiss SR, White EA, White TM, Wobus CE, Worobey M, Yamaoka S, Yurochko A. J Virol, 2024 Jan 23; 98 (1): e0179123Journal ArticleVirology-the path forward.
DOI:10.1128/jvi.01791-23 PMID: 38168672 -
Hafner A, Meurs N, Garner A, Azar E, Passalacqua KD, Nagrath D, Wobus CE. 2023 Dec 19;PreprintNorovirus NS1/2 protein increases glutaminolysis for efficient viral replication.
DOI:10.1101/2023.12.19.572316 PMID: 38187600 -
Mills JT, Minogue SC, Snowden JS, Arden WKC, Rowlands DJ, Stonehouse NJ, Wobus CE, Herod MR. J Virol, 2023 Dec 21; 97 (12): e0171923Journal ArticleAmino acid substitutions in norovirus VP1 dictate host dissemination via variations in cellular attachment.
DOI:10.1128/jvi.01719-23 PMID: 38032199
