Thomas D Wang
H Marvin Pollard Collegiate Professor of Endoscopy Research
Professor of Internal Medicine
Professor of Biomedical Engineering
[email protected]

Available to mentor

Thomas D Wang
Professor
  • About
  • Center Memberships
  • Research Overview
  • Recent Publications
  • About

    I am an ABIM board-certified gastroenterologist with broad scientific training in biology, biomedical engineering, and electrical engineering. I use my broad, multi-disciplinary expertise to bridge unmet needs in clinical medicine with technological innovations in engineering. As a physician, I use my access to the clinic to accelerate translation of discoveries found in the lab. My team has pioneered the clinical use of monomer peptides as targeted imaging agents to detect epithelia dysplasia. My lab has expertise in the development of peptide ligands that bind specifically to cell surface targets overexpressed in early-stage cancers. We have previously identified and validated peptides specific for EGFR, ErbB2, claudin-1, FGFR2, c-Met, Prdx1, GPC3, CD44, and EpCAM using phage display methods and structural models. We are expert at arranging peptides in multimer configurations to enhance multivalent binding interactions for increased sensitivity, specificity, and affinity. I have served as the PI for a number of NIH-funded research programs, including 1) Network for Translational Research (NTR), 2) Barrett’s Esophagus Translational Research Network (BETRNet), and 3) Bioengineering Research Partnership (BRP).
    Fellowship – Stanford University School of Medicine, Gastroenterology
    Residency – Boston University School of Medicine, Internal Medicine
    Graduate School – MIT (PhD)
    Medical School – Harvard Medical School (MD)

    Center Memberships
    • Center Member
      Global REACH
    • Center Member
      Rogel Cancer Center
    • Center Member
      MM-PKUHSC Joint Institute
    Research Overview

    Specialty
    Gastroenterology, Internal Medicine

    Area of practice
    General gastroenterology, gastroesophageal reflux, Barrett's esophagus, irritable bowel syndrome, colon cancer screening

    Research
    Molecular imaging of gastrointestinal diseases, development of molecular probes to target detection of pre-cancerous lesions, novel optical imaging instrumentation for high resolution imaging, advance endoscopic imaging, and intra-vital microscopy

    Recent Publications See All Publications
    • Additional Scholarship
      Data from GRAIL1 Stabilizes Misfolded Mutant p53 through a Ubiquitin Ligase-Independent, Chaperone Regulatory Function
      Ray P, Jaiswal S, Ferrer-Torres D, Wang Z, Nancarrow D, Curtin M, Martinho MS, Lacy SM, Kasturirangan S, Thomas D, Spence JR, Truttmann MC, Lagisetty KH, Lawrence TS, Wang TD, Beer DG, Ray D. 2024 Nov 1; DOI:10.1158/1541-7786.c.7520410
    • Additional Scholarship
      Supplementary Figure S1 from GRAIL1 Stabilizes Misfolded Mutant p53 through a Ubiquitin Ligase-Independent, Chaperone Regulatory Function
      Ray P, Jaiswal S, Ferrer-Torres D, Wang Z, Nancarrow D, Curtin M, Martinho MS, Lacy SM, Kasturirangan S, Thomas D, Spence JR, Truttmann MC, Lagisetty KH, Lawrence TS, Wang TD, Beer DG, Ray D. 2024 Nov 1; DOI:10.1158/1541-7786.27435436
    • Additional Scholarship
      Supplementary Figure S2 from GRAIL1 Stabilizes Misfolded Mutant p53 through a Ubiquitin Ligase-Independent, Chaperone Regulatory Function
      Ray P, Jaiswal S, Ferrer-Torres D, Wang Z, Nancarrow D, Curtin M, Martinho MS, Lacy SM, Kasturirangan S, Thomas D, Spence JR, Truttmann MC, Lagisetty KH, Lawrence TS, Wang TD, Beer DG, Ray D. 2024 Nov 1; DOI:10.1158/1541-7786.27435433
    • Additional Scholarship
      Supplementary Figure S3 from GRAIL1 Stabilizes Misfolded Mutant p53 through a Ubiquitin Ligase-Independent, Chaperone Regulatory Function
      Ray P, Jaiswal S, Ferrer-Torres D, Wang Z, Nancarrow D, Curtin M, Martinho MS, Lacy SM, Kasturirangan S, Thomas D, Spence JR, Truttmann MC, Lagisetty KH, Lawrence TS, Wang TD, Beer DG, Ray D. 2024 Nov 1; DOI:10.1158/1541-7786.27435427
    • Additional Scholarship
      Supplementary Figure S4 from GRAIL1 Stabilizes Misfolded Mutant p53 through a Ubiquitin Ligase-Independent, Chaperone Regulatory Function
      Ray P, Jaiswal S, Ferrer-Torres D, Wang Z, Nancarrow D, Curtin M, Martinho MS, Lacy SM, Kasturirangan S, Thomas D, Spence JR, Truttmann MC, Lagisetty KH, Lawrence TS, Wang TD, Beer DG, Ray D. 2024 Nov 1; DOI:10.1158/1541-7786.27435424
    • Additional Scholarship
      Supplementary Figure S5 from GRAIL1 Stabilizes Misfolded Mutant p53 through a Ubiquitin Ligase-Independent, Chaperone Regulatory Function
      Ray P, Jaiswal S, Ferrer-Torres D, Wang Z, Nancarrow D, Curtin M, Martinho MS, Lacy SM, Kasturirangan S, Thomas D, Spence JR, Truttmann MC, Lagisetty KH, Lawrence TS, Wang TD, Beer DG, Ray D. 2024 Nov 1; DOI:10.1158/1541-7786.27435418
    • Additional Scholarship
      Supplementary Figure S6 from GRAIL1 Stabilizes Misfolded Mutant p53 through a Ubiquitin Ligase-Independent, Chaperone Regulatory Function
      Ray P, Jaiswal S, Ferrer-Torres D, Wang Z, Nancarrow D, Curtin M, Martinho MS, Lacy SM, Kasturirangan S, Thomas D, Spence JR, Truttmann MC, Lagisetty KH, Lawrence TS, Wang TD, Beer DG, Ray D. 2024 Nov 1; DOI:10.1158/1541-7786.27435415
    • Additional Scholarship
      Supplementary Figure S7 from GRAIL1 Stabilizes Misfolded Mutant p53 through a Ubiquitin Ligase-Independent, Chaperone Regulatory Function
      Ray P, Jaiswal S, Ferrer-Torres D, Wang Z, Nancarrow D, Curtin M, Martinho MS, Lacy SM, Kasturirangan S, Thomas D, Spence JR, Truttmann MC, Lagisetty KH, Lawrence TS, Wang TD, Beer DG, Ray D. 2024 Nov 1; DOI:10.1158/1541-7786.27435409