Our senses rely on transformation. From the touch of a hand, to the sight of a friend, to the sound of a child, each is transformed into a neural code that ultimately leads to perception. The Duncan Laboratory team is interested in the early stages of the transformation of sound in the cochlea. Our overall goal is to understand the molecular physiology of sensory cells in the ear and the nerves that innervate them. We approach the study of these excitable cells in three inter-related areas: ion channel structure-function, development and maturation and trauma and regeneration.

Ion Channel Structure-Function: At the interface of genetics, biophysics, and biochemistry, we seek to unravel the molecular nature of excitation in the inner ear. Our laboratory is particularly interest in the structure and function of ion channels, with an emphasis on how these channels are regulated and modulated in the mature and developing ear as well as in so-called ion channelopathies. We also actively collaborate with synthetic chemistry labs to identify new potential channel therapeutics.

Stem Cells and Regeneration: Extraordinary demands of sensitivity and timing are placed on the fragile sensorineural cells of the inner ear, and as a result, small changes in inner ear physiology can greatly impact perception. Sensorineural deficits are often associated with injury or loss of sensory hair cells and the neurons that innervate them. We use various approaches to generate stem cell-derived hair cells and neurons, including 3D cultures of inner ear organoids. Current projects seek to understand the factors that tailor organoid cultures to particular fates while other projects attempt to replace damaged tissue in animal models using these organs or cells "in-a-dish".