Prashant Mahajan, MD, MPH, MBA
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About
Dr. Mahajan is certified in pediatrics and pediatric emergency medicine. In addition, he has a Master's in Public Health (Health Administration and Policy) and a Master's in Business Administration. He is currently the Chair, Section of Emergency Medicine, for the American Academy of Pediatrics. His research interests are in infection/inflammation and in the area of clinician diagnostic decision making. He has been serially funded by NIH for the evaluation of the febrile infant with the use of novel RNA expression analysis using microarrays to define bacterial and non-bacterial biosignatures. He is involved in patient safety and quality and is funded by AHRQ on the study of diagnostic errors in the pediatric emergency setting.
Qualifications
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Diploma of National BoardsNational Board of Examinations, New Delhi, India
1990 - 1993
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MB BS, Bachelor of Medicine and SurgeryUniversity of Bombay, Bombay, India
1984 - 1988
Center Memberships
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Center MemberCenter for Global Health Equity
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Center MemberAI and Digital Health Innovation
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Center MemberEisenberg Family Depression Center
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Center Membere-Health and Artificial Intelligence Initiative
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Center MemberWeil Institute for Critical Care Research
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Center MemberInstitute for Healthcare Policy and Innovation
Research Overview
My research has focused on enhancing decision making in austere circumstances such as emergency care delivery. To that end, I have co-led the first nationwide study of host immune response via transcriptomic analysis to distinguish bacterial vs. viral etiologies of fever in febrile infants in the first two months of life. I have helped develop highly precise and clinically meaningful prediction rules in the evaluation and management of young febrile infants. My second area of focus has been reduction of patient harm from the perspective of diagnostic quality in the context of emergency care. I have modified the National Academies framework on diagnostic safety for emergency care, for the first time, defined multiple electronic triggers for epidemiology and contributory factors of diagnostic errors, used artificial intelligence, including machine learning and natural language processing to investigate large datasets for diagnostic errors and finally developed the first protocol to perform ethnographic analysis of the process of diagnostic decision making in naturalistic settings. Finally, I use advanced technology such as mixed and augmented reality to enhance clinician decision making in real-time in remote settings. These endeavors have been industry funded and we have developed the first ambient intelligence module for pediatric resuscitation through the REACT Program (Research and Education in Acute Care using Advanced Technology).
Recent Publications
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Mahajan P. 2026 Mar 17;PresentationImproving Diagnosis in Emergency Medicine: Opportunities & Challenges for Diagnostic Accuracy
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Kaal A, Washer L, Wasylyshyn A, Steyerberg E, Mahajan P, van Nieuwkoop C. Sci Rep, 2026 Apr 17;Journal ArticleBacteremia prediction models to reduce unnecessary blood cultures: external validation in a large US emergency department.
DOI:10.1038/s41598-026-47024-5 PMID: 41998145 -
Aronson PL, Mahajan P, Nielsen B, Olsen CS, Meeks HD, Grundmeier RW, Kuppermann N, PECARN Registry Working Group . J Pediatr, 2026 Mar 30; 115092Journal ArticleVariation in Evaluation and Management of Febrile Infants 61 to 90 Days Old.
DOI:10.1016/j.jpeds.2026.115092 PMID: 41921773 -
Hoffmann JA, Foster AA, Rojas CR, Otto S, Olsen CS, Meeks HD, Denicolo K, Janssen A, Grupp-Phelan J, Alpern ER, PECARN Registry Study Group . JAMA Netw Open, 2026 Mar 2; 9 (3): e263042Journal ArticleOvertriage and Undertriage of Children Presenting to the Emergency Department for Behavioral Health.
DOI:10.1001/jamanetworkopen.2026.3042 PMID: PMC13014168 -
Harmer BM, Hoyle JD, Wells L, Fredericks T, Edwards A, Lecznar A, Christopher K, Dunwoody S, Hong G, Rantz W, Popov V, Mahajan P, Fogarty K. Prehosp Emerg Care, 2026 Feb 19; 1 - 15.Journal ArticleA Simulation-Based Root Cause Analysis of Pediatric Medication Dosing Errors in Emergency Medical Services.
DOI:10.1080/10903127.2026.2634106 PMID: 41712188 -
Rai NT, Mahajan P, Katyal A, Fayyaz J, Shukla DK, Rai N, Misra S. Indian Pediatrics, 2026 Jan 1;Journal ArticleImpact of Pediatric Trauma Resuscitation Module (PTRM) on Clinical Outcomes in a Level-1 Trauma Centre in India
DOI:10.1007/s13312-025-00259-3 -
Harmer BM, Hoyle JD, Edwards A, Fredericks T, Wells L, Lecznar A, Christopher K, Dunwoody S, Hong G, Rantz W, Popov V, Mahajan P, Fogarty K. Prehosp Emerg Care, 2025 Dec 8; 1 - 13.Journal ArticleAssessing the Influence of a Statewide Dosing Reference Aid on Prehospital Pediatric Medication Dosing Errors: A Mixed-Methods Simulation-Based Investigation.
DOI:10.1080/10903127.2025.2599515 PMID: 41359816 -
Zuniga YMH, Zumla A, Zuhlke LJ, Zoladl M, Ziaeian B, Zhong C, Zhao XJG, Zhang ZJ, Zhang J, Zepro NB, Zenebe GA, Zeitoun JD, Zegeye ZB, Zastrozhin MS, Zareshahrabadi Z, Zarea K, Dehnavi AZ, Zare I, Zangiabadian M, Zangeneh A, Zamora N, Zaman SB, Zaki N, Zakaryaei F, Zahir M, Tajrishi FZ, Zadnik V, Zadey S, Yusefi H, Yousefinezhadi T, Yousefi Z, Younis MZ, You Y, Yonemoto N, Yon DK, Yisihak E, Yip P, Yiğit V, Yiğit A, Yi S, Ye P, Yazdanpanah F, Yaya S, Yano Y, Yang L, Yamagishi K, Yamada T, Jabbari SHY, Yahya GATY, Yaghoubi S, Xu X, Xu S, Xu H, Xie Y, Xiao H, Wulandari RDWI, Wubetie GA, Wu AM, Woolf AD, Wolfe CDA, Woldemariam M, Tsadik DSW, Woday AT, Wickramasinghe ND, Wiangkham T, Westerman R, Wen YF, Wei MY, Waris A, Ward P, Wang Z, Wang YP, Wang Y, Wang Y, Vu LG, Volovici V, Vo B, Vlassov V, Vishwanath PM, Violante FS, Villafañe JH, Vervoort D, Veroux M, Verma M, Venketasubramanian N, Vaziri S, Vasic M, Vasankari TJ, Varughese S, Vart P, Varma RP, Vardavas C, Van den Eynde J, Valizadeh R, Valdez PR, Tahbaz SV, Vakilian A, Vacante M, Upadhyay E, Unnikrishnan B. Nature Communications, 2025 Dec 1; 16 (1):Journal ArticleCharacterising acute and chronic care needs: insights from the Global Burden of Disease Study 2019
DOI:10.1038/s41467-025-56910-x PMID: 40335470
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