Shih-Chen Kuo
Associate Research Scientist
Internal Medicine
[email protected]

Available to mentor

Shih-Chen Kuo
Associate Research Scientist
  • About
  • Qualifications
  • Center Memberships
  • Research Overview
  • Recent Publications
  • About

    I am a pharmacist-epidemiologist with expertise in clinical and diabetes epidemiology, health economics and outcomes research, and computational simulation modeling. I am an Associate Research Scientist in the Division of Metabolism, Endocrinology & Diabetes in the Department of Internal Medicine at the University of Michigan Medical School, and a member of the diabetes modeling group in the Michigan Center for Diabetes Translational Research. My research focus is to identify innovative and scalable approaches to help healthcare professionals and policymakers make sound decisions about enhancing patient-centered clinical care, health policies, and public health strategies for diabetes management, primarily by leveraging insights from pharmacoepidemiology, comparative effectiveness research, economic evaluation, computational simulation modeling, and decision-analytic sciences from the payer, healthcare sector, and societal perspectives. I have been working and collaborating with many multidisciplinary researchers in the United States and around the world to lead, co-lead, or conduct health economics and outcomes research in diabetes using data from large electronic health records, claims databases, and landmark multicenter randomized controlled trials.

    Qualifications
    • Senior Research Specialist
      University of Pittsburgh, Pittsburgh
    • Research Fellow
      University of Michigan–Ann Arbor, Ann Arbor
    • BSPharm
      Kaohsiung Medical University, Kaohsiung City
    • MS
      National Cheng Kung University, Tainan City
    • PhD
      University of Pittsburgh, Pittsburgh
    Center Memberships
    • Center Member
      Global REACH
    • Center Member
      Caswell Diabetes Institute
    Research Overview

    Health economics and outcomes research
    Clinical and diabetes epidemiology
    Computational simulation modeling and decision-analytical sciences
    Health services research

    Recent Publications See All Publications
    • Journal Article
      Cost-Effectiveness of the National Diabetes Prevention Program: A Real-World, 2-Year Prospective Study.
      Kuo S, Ye W, Wang D, McEwen LN, Villatoro Santos C, Herman WH. Diabetes Care, 2024 Nov 20; DOI:10.2337/dc24-1110
      PMID: 39565893
    • Journal Article
      Differential Effects of Type 2 Diabetes Treatment Regimens on Diabetes Distress and Depressive Symptoms in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE).
      Gonzalez JS, Bebu I, Krause-Steinrauf H, Hoogendoorn CJ, Crespo-Ramos G, Presley C, Naik AD, Kuo S, Johnson ML, Wexler D, Crandall JP, Bantle AE, Arends V, Cherrington AL, GRADE Research Group . Diabetes Care, 2024 Apr 1; 47 (4): 610 - 619. DOI:10.2337/dc23-2459
      PMID: 38416773
    • Journal Article
      Impact of Glucose-Lowering Medications on Health-Related Quality of Life in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE).
      Cherrington AL, Tripputi MT, Younes N, Herman WH, Katona A, Groessl EJ, Craig J, Gonzalez JS, Garg R, Casula S, Kuo S, Florez HJ, GRADE Research Group . Diabetes Care, 2024 Apr 1; 47 (4): 603 - 609. DOI:10.2337/dc23-1648
      PMID: 38190625
    • Journal Article
      Cardiovascular Outcomes in GRADE (Glycemia Reduction Approaches in Type 2 Diabetes: A Comparative Effectiveness Study).
      Green JB, Everett BM, Ghosh A, Younes N, Krause-Steinrauf H, Barzilay J, Desouza C, Inzucchi SE, Pokharel Y, Schade D, Scrymgeour A, Tan MH, Utzschneider KM, Mudaliar S, GRADE Study Research Group . Circulation, 2024 Mar 26; 149 (13): 993 - 1003. DOI:10.1161/CIRCULATIONAHA.123.066604
      PMID: 38344820
    • Journal Article
      Lower risks of cirrhosis and hepatocellular carcinoma with GLP-1RAs in type 2 diabetes: A nationwide cohort study using target trial emulation framework.
      Yang C-T, Yao W-Y, Yang C-Y, Peng Z-Y, Ou H-T, Kuo S. J Intern Med, 2024 Mar; 295 (3): 357 - 368. DOI:10.1111/joim.13751
      PMID: 37994187
    • Journal Article
      Chronic kidney outcomes associated with GLP-1 receptor agonists versus long-acting insulins among type 2 diabetes patients requiring intensive glycemic control: a nationwide cohort study.
      Peng Z-Y, Yang C-T, Lin W-H, Yao W-Y, Ou H-T, Kuo S. Cardiovasc Diabetol, 2023 Oct 4; 22 (1): 272 DOI:10.1186/s12933-023-01991-5
      PMID: 37794465
    • Journal Article
      Erratum to "IDF Diabetes Atlas: Global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045" [Diabetes Res. Clin. Pract. 183 (2022) 109119].
      Sun H, Saeedi P, Karuranga S, Pinkepank M, Ogurtsova K, Duncan BB, Stein C, Basit A, Chan JCN, Claude Mbanya J, Pavkov ME, Ramachandaran A, Wild SH, James S, Herman WH, Zhang P, Bommer C, Kuo S, Boyko EJ, Magliano DJ. Diabetes Res Clin Pract, 2023 Oct; 204: 110945 DOI:10.1016/j.diabres.2023.110945
      PMID: 37863776
    • Journal Article
      Diabetes Care Barriers, Use, and Health Outcomes in Younger Adults With Type 1 and Type 2 Diabetes.
      Pihoker C, Braffett BH, Songer TJ, Herman WH, Tung M, Kuo S, Bellatorre A, Isganaitis E, Jensen ET, Divers J, Zhang P, Nathan DM, Drews K, Dabelea D, Zeitler PS, Writing Committee for the SEARCH for Diabetes in Youth Study Group and the TODAY Study Group . JAMA Netw Open, 2023 May 1; 6 (5): e2312147 DOI:10.1001/jamanetworkopen.2023.12147
      PMID: 37145592