Gary D Hammer

Gary Hammer
Millie Schembechler Professor of Adrenal Cancer
Professor of Internal Medicine
Program Director, Internal Medicine
Professor of Molecular and Integrative Physiology
Professor of Cell and Developmental Biology
Medical School
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Available to mentor
Gary D Hammer
Gary Hammer
Professor
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  • About

    Gary D. Hammer, M.D., Ph.D. is a Professor in the Departments of Internal Medicine (MEND), Cell & Developmental Biology, and Molecular & Integrative Physiology. He currently serves as the Director of Endocrine Oncology Program in the Rogel Cancer Center where he holds the Millie Schembechler Professorship in Adrenal Cancer. He is the past Director of The Center for Organogenesis: Stem Cells & Regenerative Medicine. He has brokered the recent renaissance of the current Michigan team of adrenal scientists that includes a who’s who in the study of adrenal disease. Research projects in his own laboratory are aimed at elucidating the mechanisms by which growth factor signaling and transcriptional programs initiate adrenal-specific growth and differentiation with an emphasis on dysregulated adrenocortical stem cells in development and homeostasis with implications for regenerative medicine and cancer. He received the UofM Jerome Conn Award for Outstanding Research in Internal Medicine, the Endocrine Society Edwin B. Astwood Award for Outstanding Research and is a member of ASCI and AAP. He has served in numerous leadership roles at U of M and in the public and private sectors including recent tenure on Board of Scientific Advisors for NCI. He has served in numerous capacities for the world’s largest endocrine organization, the Endocrine Society, including his most recent role as President of the Society (2020-2021). As Advisor to the Congressional H.E.L.P. committee, he co-authored “The 21st Century Cancer ALERT (Access to Life-Saving Early detection, Research and Treatment) Act’’ introduced in Congress in 2009. He is the editor of four textbooks: Adrenocortical Carcinoma: Basic Science and Clinical Concepts (Springer, 2011), Pathophysiology of Disease: An Introduction to Clinical Medicine (Harper Row, 2014; 2018; 2026), Genetics Steroid Disorders 2nd edition (Elsevier, 2023) and the Adrenal Section Editor for Degroot’s Endocrinology, 8th and 9th edition (Elsevier, 2022; 2026). He has been catalyst for the formation of two international cooperative groups, most recently the American Australian Asian Adrenal Alliance (A5) that leverages collaboration to secure projects from Pharma and funding agencies across the spectrum of adrenal diseases. Such work with colleagues has led to the development of new national and international therapeutic trials with biological-based therapies while sparing normal tissue. He is a co-founder of two companies - MILLENDO and SLING THERAPEUTICS, that focus on rare endocrine diseases.

    Links

    • Hammer lab website

    Center Memberships

    • Center Member
      Global REACH
    • Center Member
      Rogel Cancer Center
    • Center Member
      Biosciences Initiative
    • Center Member
      Center for Cell Plasticity and Organ Design

    Recent Publications

    See All Publications
    • Journal Article
      The transcription factor HHEX maintains glucocorticoid levels and protects adrenals from androgen-induced lipid depletion
      Dumontet T, Basham KJ, Foster MC, Silverman E, Heard KA, Johnson D, Lee C, Plaska SW, Breault DT, Penton D, Beuschlein F, Turcu AF, LaPensee CR, Marcondes Lerario A, Hammer GD. Nature Communications, 2026 Dec 1; 17 (1): DOI:10.1038/s41467-025-68257-4
      PMID: 41519914
    • Journal Article
      Automated clinical production, dosimetry estimates and preclinical safety considerations for clinical translation of a SOAT1-targeted PET imaging agent
      Kaup G, Kaur T, Henderson BD, Winton WP, Hill JR, Raffel DM, Stauff J, Wong KK, Brooks AF, Shao X, Hammer GD, Viglianti BL, Scott PJH. Nuclear Medicine and Biology, 2026 Nov 1; 162-163: DOI:10.1016/j.nucmedbio.2026.109681
    • Journal Article
      Single-cell resolution in adrenocortical carcinoma: from pathogenesis to treatment
      Mohan DR, Hammer GD, Lerario AM. Current Opinion in Endocrinology Diabetes and Obesity, 2026 Oct 1; 33 (5): 204 - 209. DOI:10.1097/MED.0000000000000974
      PMID: 42590935
    • Patent
      Compositions and Methods for Treating Cancer
      Marcondes Lerario A, Mohan DR, Hammer G. 2026 Sep 10;
    • Journal Article
      Integrated system for characterization of malignant and benign adrenal lesions and differentiation of high‑ and low‑risk adrenal cancer on CT scans using radiomics‑based decision support
      Yordanova A, Hadjiiski L, Day R, Fiori S, Caoili EM, Cohan RH, Chan H-P, Worden F, Hammer G, Wilms M, Zhou C. 2026 Apr 30; 93 - 93. DOI:10.1117/12.3087435
    • Journal Article
      Adrenocortical carcinoma as a manifestation of Birt–Hogg–Dubé syndrome
      Wolf KI, Osborne J, Lerario AM, Vo JN, Hamidi O, Habra MA, Hammer G, Else T. Endocrine Related Cancer, 2026 Mar 1; 33 (3): DOI:10.1530/ERC-25-0285
      PMID: 41838460
    • Journal Article
      EndoBridge 2025: pearls and highlights
      Yildiz BO, Armenti M, Brandi ML, Carey J, Carling T, Ciudin A, Dhatariya K, Fountas A, Frühbeck G, Goulis D, Grammatikopoulou M, Gurnell M, Hammer GD, Hirschberg AL, Jawad S, Jonklaas J, Kaiser U, Karavitaki N, Khan A, Lezaic L, MacFarlane J, Macut D, Mader JK, McGowan B, Patel D, Philis-Tsimikas A, Radić L, Salvi M, San Diego ERN, Siggelkow H, Stratakis CA, Yazici D, Celik O. Hormones, 2026 Jan 1; DOI:10.1007/s42000-026-00804-0
    • Proceeding / Abstract / Poster
      Integrated system for characterization of malignant and benign adrenal lesions and differentiation of high and low risk adrenal cancer on CT scans using radiomics based decision support
      Yordanova A, Hadjiiski LSA, Day R, FiorI S, Caoili EM, Cohan RH, Chan HP, Worden F, Hammer G, Wilms M, Zhou C. 2026 May 9;

    Featured News & Stories

    Double portrait of the Templemans smiling and standing together affectionately.
    Philanthropy News

    Rare cancer diagnosis inspires community of support

    After overcoming adrenocortical carcinoma at U-M and UCLA, Jill Templeman and her husband Michael are giving back by supporting cancer research at Michigan Medicine.
    Department News

    New Publication by the Hammer Lab

    "Senescence-induced immune remodeling facilitates metastatic adrenal cancer in a sex-dimorphic manner," was published in Nature Aging.