Gary D Hammer
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About
Gary D. Hammer, M.D., Ph.D. is a Professor in the Departments of Internal Medicine (MEND), Cell & Developmental Biology, and Molecular & Integrative Physiology. He currently serves as the Director of Endocrine Oncology Program in the Rogel Cancer Center where he holds the Millie Schembechler Professorship in Adrenal Cancer. He is the past Director of The Center for Organogenesis: Stem Cells & Regenerative Medicine. He has brokered the recent renaissance of the current Michigan team of adrenal scientists that includes a who’s who in the study of adrenal disease. Research projects in his own laboratory are aimed at elucidating the mechanisms by which growth factor signaling and transcriptional programs initiate adrenal-specific growth and differentiation with an emphasis on dysregulated adrenocortical stem cells in development and homeostasis with implications for regenerative medicine and cancer. He received the UofM Jerome Conn Award for Outstanding Research in Internal Medicine, the Endocrine Society Edwin B. Astwood Award for Outstanding Research and is a member of ASCI and AAP. He has served in numerous leadership roles at U of M and in the public and private sectors including recent tenure on Board of Scientific Advisors for NCI. He has served in numerous capacities for the world’s largest endocrine organization, the Endocrine Society, including his most recent role as President of the Society (2020-2021). As Advisor to the Congressional H.E.L.P. committee, he co-authored “The 21st Century Cancer ALERT (Access to Life-Saving Early detection, Research and Treatment) Act’’ introduced in Congress in 2009. He is the editor of four textbooks: Adrenocortical Carcinoma: Basic Science and Clinical Concepts (Springer, 2011), Pathophysiology of Disease: An Introduction to Clinical Medicine (Harper Row, 2014; 2018; 2026), Genetics Steroid Disorders 2nd edition (Elsevier, 2023) and the Adrenal Section Editor for Degroot’s Endocrinology, 8th and 9th edition (Elsevier, 2022; 2026). He has been catalyst for the formation of two international cooperative groups, most recently the American Australian Asian Adrenal Alliance (A5) that leverages collaboration to secure projects from Pharma and funding agencies across the spectrum of adrenal diseases. Such work with colleagues has led to the development of new national and international therapeutic trials with biological-based therapies while sparing normal tissue. He is a co-founder of two companies - MILLENDO and SLING THERAPEUTICS, that focus on rare endocrine diseases.
Links
Hammer lab website
Center Memberships
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Center MemberGlobal REACH
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Center MemberRogel Cancer Center
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Center MemberBiosciences Initiative
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Center MemberCenter for Cell Plasticity and Organ Design
Recent Publications
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Dumontet T, Basham KJ, Foster MC, Silverman E, Heard KA, Johnson D, Lee C, Plaska SW, Breault DT, Penton D, Beuschlein F, Turcu AF, LaPensee CR, Marcondes Lerario A, Hammer GD. Nature Communications, 2026 Dec 1; 17 (1):Journal ArticleThe transcription factor HHEX maintains glucocorticoid levels and protects adrenals from androgen-induced lipid depletion
DOI:10.1038/s41467-025-68257-4 PMID: 41519914 -
Kaup G, Kaur T, Henderson BD, Winton WP, Hill JR, Raffel DM, Stauff J, Wong KK, Brooks AF, Shao X, Hammer GD, Viglianti BL, Scott PJH. Nuclear Medicine and Biology, 2026 Nov 1; 162-163:Journal ArticleAutomated clinical production, dosimetry estimates and preclinical safety considerations for clinical translation of a SOAT1-targeted PET imaging agent
DOI:10.1016/j.nucmedbio.2026.109681 -
Mohan DR, Hammer GD, Lerario AM. Current Opinion in Endocrinology Diabetes and Obesity, 2026 Oct 1; 33 (5): 204 - 209.Journal ArticleSingle-cell resolution in adrenocortical carcinoma: from pathogenesis to treatment
DOI:10.1097/MED.0000000000000974 PMID: 42590935 -
Marcondes Lerario A, Mohan DR, Hammer G. 2026 Sep 10;PatentCompositions and Methods for Treating Cancer
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Yordanova A, Hadjiiski L, Day R, Fiori S, Caoili EM, Cohan RH, Chan H-P, Worden F, Hammer G, Wilms M, Zhou C. 2026 Apr 30; 93 - 93.Journal ArticleIntegrated system for characterization of malignant and benign adrenal lesions and differentiation of high‑ and low‑risk adrenal cancer on CT scans using radiomics‑based decision support
DOI:10.1117/12.3087435 -
Wolf KI, Osborne J, Lerario AM, Vo JN, Hamidi O, Habra MA, Hammer G, Else T. Endocrine Related Cancer, 2026 Mar 1; 33 (3):Journal ArticleAdrenocortical carcinoma as a manifestation of Birt–Hogg–Dubé syndrome
DOI:10.1530/ERC-25-0285 PMID: 41838460 -
Yildiz BO, Armenti M, Brandi ML, Carey J, Carling T, Ciudin A, Dhatariya K, Fountas A, Frühbeck G, Goulis D, Grammatikopoulou M, Gurnell M, Hammer GD, Hirschberg AL, Jawad S, Jonklaas J, Kaiser U, Karavitaki N, Khan A, Lezaic L, MacFarlane J, Macut D, Mader JK, McGowan B, Patel D, Philis-Tsimikas A, Radić L, Salvi M, San Diego ERN, Siggelkow H, Stratakis CA, Yazici D, Celik O. Hormones, 2026 Jan 1;Journal ArticleEndoBridge 2025: pearls and highlights
DOI:10.1007/s42000-026-00804-0 -
Yordanova A, Hadjiiski LSA, Day R, FiorI S, Caoili EM, Cohan RH, Chan HP, Worden F, Hammer G, Wilms M, Zhou C. 2026 May 9;Proceeding / Abstract / PosterIntegrated system for characterization of malignant and benign adrenal lesions and differentiation of high and low risk adrenal cancer on CT scans using radiomics based decision support
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