Gary D Hammer
Millie Schembechler Professor of Adrenal Cancer
Professor of Internal Medicine
Professor of Molecular and Integrative Physiology
Professor of Cell and Developmental Biology
[email protected]

Available to mentor

Gary D Hammer
Professor
  • About
  • Center Memberships
  • Recent Publications
  • About

    Gary D. Hammer, M.D., Ph.D. is Professor in Departments of Internal Medicine (MEND), Cell & Developmental Biology, and Molecular & Integrative Physiology. He currently serves as Director of Endocrine Oncology Program in Rogel Cancer Center where he holds the Millie Schembechler Professorship in Adrenal Cancer. He is past Director of Center for Organogenesis: Stem Cells & Regenerative Medicine. He has brokered the recent renaissance of the current Michigan team of adrenal scientists that includes a who’s who in the study of adrenal disease. Research projects in his own laboratory are aimed at elucidating the mechanisms by which growth factor signaling and transcriptional programs initiate adrenal-specific growth and differentiation with an emphasis on dysregulated adrenocortical stem cells in development and homeostasis with implications for regenerative medicine and cancer. He received the UofM Jerome Conn Award for Outstanding Research in Internal Medicine, the Endocrine Society Edwin B. Astwood Award for Outstanding Research and is a member of ASCI and AAP. He has served in numerous leadership roles at UofM and in the public and private sectors including recent tenure on Board of Scientific Advisors for NCI. He is the editor of four textbooks including Pathophysiology of Disease: An Introduction to Clinical Medicine (McGraw Hill), and the Adrenal Section Editor for Degroot’s Endocrinology (Elsevier). He has served in numerous capacities for the world’s largest endocrine organization, the Endocrine Society including his most recent role as President of the Society (2020-2021). An Advisor to the Congressional H.E.L.P. committee - he co-authored the 21st Century Cancer ALERT (Access to Life-Saving Early detection, Research and Treatment) Act’’ introduced in Congress in 2009. He has been catalyst for the formation of two international cooperative groups, most recently the A5 (American Australian Asian Adrenal Alliance) that leverages collaboration to secure projects from Pharma and funding agencies across the spectrum of adrenal diseases. Such work with colleagues has led to the development of new national and international therapeutic trials with biological-based therapies for adrenal cancer that target the molecular defects in endocrine disease while sparing normal tissue. He is a co-founder of two companies - MILLENDO and SLING THERAPEUTICS that focus on rare endocrine diseases.

    Center Memberships
    • Center Member
      Global REACH
    • Center Member
      Biosciences Initiative
    • Center Member
      Rogel Cancer Center
    • Center Member
      Center for Cell Plasticity and Organ Design
    Recent Publications See All Publications
    • Journal Article
      12515 Single-Nuclei Multiome Analysis Of The Adrenal Gland Identifies Putative Novel Regulators Of Zone-Specific Steroidogenesis
      Lerario AM, Rege J, Blinder A, Hammer GD, Rainey WE. Journal of the Endocrine Society, 2024 Oct 5; 8 (Supplement_1): bvae163.293 DOI:10.1210/jendso/bvae163.293
    • Journal Article
      12540 Epigenetic Subtyping Of Adrenocortical Carcinoma In Archival Material And Implications For Disease Evolution
      Mohan D, Lerario AM, Almeida MQ, Mendonca BB, Latronico A, Fragoso MC, Hammer GD. Journal of the Endocrine Society, 2024 Oct 5; 8 (Supplement_1): bvae163.176 DOI:10.1210/jendso/bvae163.176
    • Journal Article
      12673 Epigenetic Subtyping Of Adrenocortical Carcinoma In Archival Material And Implications For Disease Evolution
      Mohan D, Lerario AM, Almeida MQ, Mendonca BB, Latronico A, Fragoso MC, Hammer GD. Journal of the Endocrine Society, 2024 Oct 5; 8 (Supplement_1): bvae163.175 DOI:10.1210/jendso/bvae163.175
    • Proceeding / Abstract / Poster
      7887 Non-Canonical Wnt Signaling Via WNT2B Is Critical For Adrenal Morphogenesis and Aldosterone Production
      Borges KS, Little DW, de Almeida Magalhães T, Ribeiro C, Basham K, Dumonte T4, Azova S, O’Connell AE, Guagliardo NA, Barrett PQ, Berber M, Mohan D, Turcu A, Rainey W, Lerario AM, Carlone DL, Salic A, Breault DT, Hammer GD. Journal of the Endocrine Society, 2024 Oct 5; 8 (Supplement_1): bvae163.598 DOI:10.1210/jendso/bvae163.598
    • Additional Scholarship
      Data from β-catenin-driven differentiation is a tissue-specific epigenetic vulnerability in adrenal cancer
      Mohan DR, Borges KS, Finco I, LaPensee CR, Rege J, Solon AL, Little DW, Else T, Almeida MQ, Dang D, Haggerty-Skeans J, Apfelbaum AA, Vinco M, Wakamatsu A, Mariani BMP, Amorim LC, Latronico AC, Mendonca BB, Zerbini MCN, Lawlor ER, Ohi R, Auchus RJ, Rainey WE, Marie SKN, Giordano TJ, Venneti S, Fragoso MCBV, Breault DT, Lerario AM, Hammer GD. 2024 Sep 16; DOI:10.1158/0008-5472.c.6711185
    • Preprint
      Non-canonical Wnt signaling triggered by WNT2B drives adrenal aldosterone production.
      Borges KS, Little DW, Magalhães TDA, Ribeiro C, Dumontet T, Lapensee C, Basham KJ, Seth A, Azova S, Guagliardo NA, Barrett PQ, Berber M, O'Connell AE, Turcu AF, Lerario AM, Mohan DR, Rainey W, Carlone DL, Hirschhorn JN, Salic A, Breault DT, Hammer GD. 2024 Aug 24; DOI:10.1101/2024.08.23.609423
      PMID: 39229119
    • Journal Article
      EndoBridge 2023: highlights and pearls.
      Yildiz BO, Boguszewski CL, da Silva Boguszewski MC, Busetto L, Celik O, Fuleihan GE-H, Goulis DG, Hammer GD, Haymart MR, Kaltsas G, Law JR, Lim AYL, Luger A, Macut D, McGowan B, McClung M, Miras AD, Patti ME, Peeters RP, Pignatelli D, Saeed H, Sipos J, Stratakis CA, Tsoli M, van der Lely AJ, Witchel SF, Yazici D. Hormones (Athens), 2024 Jun; 23 (2): 183 - 204. DOI:10.1007/s42000-024-00549-8
      PMID: 38619812
    • Proceeding / Abstract / Poster
      HHEX is Required for Maintaining Circulating Glucocorticoid Levels Through Expression of Steroid Transporter ABCB1 and Regulation of Lipid Droplet Homeostasis in the Adrenal Cortex
      Dumontet T, Basham K, Foster M, Heard K, Lapensee C, Bothou C, Beuschlein F, Rainey W, Turcu AF, Lerario A, Hammer G. 99, 2024 May 10; OC3.4: DOI:10.1530/endoabs.99.oc3.4
    Featured News & Stories
    Department News
    New Publication by the Hammer Lab
    "Senescence-induced immune remodeling facilitates metastatic adrenal cancer in a sex-dimorphic manner," was published in Nature Aging.