Alnawaz Rehemtulla, PhD
Professor of Radiation Oncology
Professor of Radiology
Radiation Oncology
1600 Huron Parkway
Ann Arbor, MI 48109
[email protected]

Available to mentor

Alnawaz Rehemtulla, PhD
Professor
  • About
  • Center Memberships
  • Research Overview
  • Recent Publications
  • About

    Dr. Rehemtulla has over 25 years of research experience in the field of oncogenic signaling in cancer as well as development and evaluation of inhibitors for these signaling pathways as anticancer therapies. He has developed technologies that enable non-invasive imaging of signaling pathways in cells as well as in mouse models of cancer. These technologies have been leveraged for the discovery of novel drugs that target oncogenic pathways and have antitumor activity. He has also utilized the ability to monitor signaling pathways in live cells to identify previously unappreciated signaling hubs that mediate the transformed phenotype.

    Center Memberships
    • Center Member
      Rogel Cancer Center
    Research Overview

    Combining small molecules that inhibit oncogenic pathways with ionizing radiation to improve the efficacy of radiation therapy in brain and pancreatic cancer. Specifically, he is evaluating agents that target the cellular DNA damage response as radiation sensitizers.
    Signaling pathways that mediate therapeutic resistance in brain tumors.
    Pathways that enhance the capacity of tumor cells to tolerate radiation therapy by enhancing the capacity to repair damaged DNA are being investigated for therapeutic intervention to restore sensitivity to radiation.

    Recent Publications See All Publications
    • Preprint
      A molecularly engineered lectin destroys EGFR and inhibits the growth of non-small cell lung cancer.
      Chan SM, Raglow Z, Pal A, Gitlin SD, Legendre M, Thomas D, Mehta RK, Tan M, Nyati MK, Rehemtulla A, Markovitz DM. 2024 Mar 20; DOI:10.1101/2024.03.18.585535
      PMID: 38562773
    • Journal Article
      Abstract B001: Glioblastoma evolution and resistance is mediated by a shift in cell state and tumor microenvironmental interactions
      Shankar S, Ravikumar V, Tripathy A, Ji S, Loper J, Hassan Z, Fehmi Z, Haydin Y, Huang D-L, Bhadury S, Kulkarni R, Regier J, Wahl D, Rao A, Rehemtulla A, Al-Holou WN. Cancer Research, 2024 Mar 4; 84 (5_Supplement_1): b001 - b001. DOI:10.1158/1538-7445.brain23-b001
    • Journal Article
      TMIC-44. THY1 CONFERS PROLIFERATIVE ADVANTAGES AND THERAPY RESISTANCE WITHIN LOCALIZED NICHES OF GLIOMA
      Ravikumar V, Shankar S, Ji S, Hassan Z, Haydin Y, Huang D-L, Fehmi Z, Rehemtulla A, Rao A, Al-holou W. Neuro-Oncology, 2023 Nov 10; 25 (Supplement_5): v288 - v288. DOI:10.1093/neuonc/noad179.1110
    • Journal Article
      A lipid-associated macrophage lineage rewires the spatial landscape of adipose tissue in early obesity
      Stansbury CM, Dotson GA, Pugh H, Rehemtulla A, Rajapakse I, Muir LA. JCI Insight, 2023 Oct 9; 8 (19): e171701 DOI:10.1172/jci.insight.171701
    • Journal Article
      Lung cancer lesion detection in histopathology images using graph-based sparse PCA network.
      Ram S, Tang W, Bell AJ, Pal R, Spencer C, Buschhaus A, Hatt CR, diMagliano MP, Rehemtulla A, Rodríguez JJ, Galban S, Galban CJ. Neoplasia, 2023 Aug; 42: 100911 DOI:10.1016/j.neo.2023.100911
      PMID: 37269818
    • Journal Article
      A lipid-associated macrophage lineage rewires the spatial landscape of adipose tissue in early obesity.
      Stansbury CM, Dotson GA, Pugh H, Rehemtulla A, Rajapakse I, Muir LA. JCI Insight, 2023 Oct 9; 8 (19): DOI:10.1172/jci.insight.171701
      PMID: 37651193
    • Journal Article
      The adapter protein FADD provides an alternate pathway for entry into the cell cycle by regulating APC/C-Cdh1 E3 ubiquitin ligase activity.
      Awadia S, Sitto M, Ram S, Ji W, Liu Y, Damani R, Ray D, Lawrence TS, Galban CJ, Cappell SD, Rehemtulla A. J Biol Chem, 2023 Jun; 299 (6): 104786 DOI:10.1016/j.jbc.2023.104786
      PMID: 37146968
    • Proceeding / Abstract / Poster
      Abstract 3909: THY1 regulates therapy resistance in glioblastoma recurrence
      Shankar S, Ravikumar V, Wang H, Ji S, Hasan Z, Fehmi Z, Haydin Y, Wahl DR, Rao A, Rehemtulla A, Al-Holou W. Cancer Research, 2023 Apr 4; 83 (7_Supplement): 3909 - 3909. DOI:10.1158/1538-7445.am2023-3909