1301 Catherine Street, Medical Sciences Building 1, room 6436
Ann Arbor, MI 48109
Available to mentor
In the Fabiilli Lab, we study how biomaterials can be modulated using focused ultrasound. Focused ultrasound enables on-demand, non-invasive, and spatiotemporally controlled generation of acoustic mechanisms within biomaterials. We use these acoustic mechanisms to control drug release from biomaterials and the physical properties of the material itself. Our goal is to utilize the interaction of focused ultrasound and biomaterials to develop new therapies to address unmet medical needs.
Fabiilli Lab
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Postdoctoral FellowUniversity of Michigan, United States
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Ph.D., Biomedical EngineeringUniversity of Michigan, Ann Arbor
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M.S.E., Biomedical EngineeringUniversity of Michigan–Ann Arbor, Ann Arbor
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B.S.E., Chemical EngineeringUniversity of Michigan–Ann Arbor, Ann Arbor
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Center MemberSamuel and Jean Frankel Cardiovascular Center
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Center MemberCenter for Cell Plasticity and Organ Design
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Center MemberBiosciences Initiative
1. Developing ultrasound-responsive biomaterials for molecular imaging and drug therapy
2. Understanding the acoustic mechanisms involved in ultrasound-based, drug delivery
3. Identifying how acoustic mechanisms impact the structure and bioactivity of therapeutic payloads delivered via ultrasound
4. Identifying the effects of therapeutic ultrasound at the cellular, tissue, and organism level
5. Elucidating how highly focal delivery effects biological processes
6. Designing highly biocompatible, ultrasound-responsive delivery vehicles
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Maji S, Aliabouzar M, Quesada C, Chiravuri A, Macpherson A, Pinch A, Kazyak K, Emara Z, Abeid BA, Kent RN, Midekssa FS, Zhang M, Baker BM, Franceschi RT, Fabiilli ML. Bioact Mater, 2025 Jan; 43: 82 - 97.Journal ArticleUltrasound-generated bubbles enhance osteogenic differentiation of mesenchymal stromal cells in composite collagen hydrogels.
DOI:10.1016/j.bioactmat.2024.09.018 PMID: 39345992 -
Abeid BA, Fabiilli ML, Aliabouzar M, Estrada JB. J Mech Behav Biomed Mater, 2024 Dec; 160: 106776Journal ArticleExperimental & numerical investigations of ultra-high-speed dynamics of optically induced droplet cavitation in soft materials.
DOI:10.1016/j.jmbbm.2024.106776 PMID: 39488187 -
Zhao W, Li Q, He P, Li C, Aryal M, Fabiilli ML, Xiao H. J Control Release, 2024 Nov; 375: 552 - 573.Journal ArticleCharge balanced aggregation: A universal approach to aqueous organic nanocrystals.
DOI:10.1016/j.jconrel.2024.09.017 PMID: 39276800 -
Xiao H, Aliabouzar M, Fabiilli ML. J Control Release, 2024 Oct; 374: 205 - 218.Journal ArticleAcoustically responsive scaffolds: Unraveling release kinetics and mechanisms for sustained, steady drug delivery.
DOI:10.1016/j.jconrel.2024.08.001 PMID: 39127447 -
Kaushik A, Abeid BA, Estrada JB, Fowlkes JB, Fabiilli ML, Aliabouzar M. Ultrason Sonochem, 2024 Oct; 109: 106984Journal ArticleThe radial dynamics and acoustic emissions of phase-shift droplets are impacted by mechanical properties of tissue-mimicking hydrogels.
DOI:10.1016/j.ultsonch.2024.106984 PMID: 39018892 -
Zhao W, Li Q, He P, Li C, Aryal M, Fabiilli ML, Xiao H. bioRxiv,PreprintPure Nano Genesis: Pioneering Universal Aqueous Nanostrategies from Pure Molecules to Revolutionise Diverse Applications
DOI:10.1101/2024.03.24.586367 -
Kaushik A, Abeid BA, Estrada JB, Fabiilli ML, Aliabouzar M. The Journal of the Acoustical Society of America, 2024 Mar 1; 155 (3_Supplement): a286 - a286.Journal ArticleCharacterization of acoustic droplet vaporization in tissue-mimicking, fibrin-based hydrogels for microrheology applications
DOI:10.1121/10.0027525 -
Maji S, Aliabouzar M, Quesada C, Macpherson A, Zhang M, Baker BM, Franceschi R, Fabiilli ML. The Journal of the Acoustical Society of America, 2024 Mar 1; 155 (3_Supplement): a287 - a287.Journal ArticleLocalized compaction of collagen hydrogels using acoustic droplet vaporization promotes osteogenic differentiation of mesenchymal stem cells
DOI:10.1121/10.0027529
