David M Raffel
Research Associate Professor
Radiology
2276 Med Sci I, 1301 Catherine
Ann Arbor, MI 48109
[email protected]

Available to mentor
David M Raffel
Research Associate Professor
  • About
  • Research Overview
  • Recent Publications
    • About

    Prof. David M. Raffel received a Bachelor of Science degree in Astronomy-Physics from the University of Wisconsin-Madison in 1983. Continuing his studies in Madison, he obtained a Ph.D. in Medical Physics from the University of Wisconsin in 1991. He then spent two years as a postdoctoral fellow at the Service Hospitalier Frédéric Joliot (SHFJ), of the French Atomic Energy Commission (CEA), in Orsay, France, working under mentors André Syrota, M.D., Ph.D. and Bernard Maziére, Ph.D. He has been a faculty member of the Division of Nuclear Medicine at the University of Michigan Medical School since 1993. Prof. Raffel is Director of Radiation Health Physics in the Division of Nuclear Medicine, and teaches the course "Physics in Nuclear Medicine" to radiology residents and nuclear medicine fellows.

    Research Overview

    - Compartmental modeling of radiotracer kinetics in positron emission tomography (PET)
    - Development and validation of novel radiotracers for PET studies of cardiac innervation
    - Investigation of changes in autonomic function in cardiac and neurodegenerative diseases
    - Development of novel radiotracers for scintigraphic detection of adrenergic tumors

    Recent Publications See All Publications
    • Journal Article
      Automated radiosynthesis and preclinical imaging of a novel [18F]fluorolidocaine analogue via sequential C-H radiolabelling.
      Frazier M, Wright JS, Raffel DM, Stauff J, Winton WP, Scott PJH, Brooks AF. RSC Med Chem, 2024 Jul 31; DOI:10.1039/d4md00293h
      PMID: 39185448
    • Journal Article
      Cardiac sympathetic denervation and anxiety in Parkinson disease.
      Carli G, Kanel P, Michalakis F, Roytman S, Bohnen JLB, Wigstrom TP, Scott P, Albin RL, Wong KK, Raffel D, Bohnen NI. Parkinsonism Relat Disord, 2024 Jul; 124: 106997 DOI:10.1016/j.parkreldis.2024.106997
      PMID: 38723520
    • Journal Article
      3-[18F]Fluoro-para-hydroxyphenethylguanidine (3-[18F]pHPG) PET-A Novel Imaging Modality for Paraganglioma.
      Else T, Wong KK, Frey KA, Brooks AF, Viglianti BL, Raffel DM. J Endocr Soc, 2024 Apr 6; 8 (6): bvae049 DOI:10.1210/jendso/bvae049
      PMID: 38617812
    • Journal Article
      Extrahepatic 90Y Complication; Gastric Ulcer Secondary to 90Y Therapy for Liver Metastasis Despite Negative Preprocedural Imaging.
      Shea C, Lamberg H, Turk S, Sanogo M, Turgeon D, Nojkov B, Frey K, Raffel D. Nucl Med Mol Imaging, 2024 Apr; 58 (2): 86 - 91. DOI:10.1007/s13139-023-00828-z
      PMID: 38510819
    • Journal Article
      Correction to: Noradrenergic cardiac denervation is associated with gait velocity in Parkinson disease: a dual ligand PET study.
      Carli G, Kanel P, Roytman S, Pongmala C, Albin RL, Raffel DM, Scott PJH, Bohnen NI. Eur J Nucl Med Mol Imaging, 2024 Jul 29; DOI:10.1007/s00259-024-06839-y
      PMID: 39073432
    • Journal Article
      Noradrenergic cardiac denervation is associated with gait velocity in Parkinson disease: a dual ligand PET study.
      Carli G, Kanel P, Roytman S, Pongmala C, Albin RL, Raffel DM, Scott PJH, Bohnen NI. Eur J Nucl Med Mol Imaging, 2024 Jul 3; DOI:10.1007/s00259-024-06822-7
      PMID: 38958681
    • Journal Article
      O-35 11C-guanylated histamine for PET cardiac imaging
      Mhanna K, Brooks A, Witek J, Kaur T, Raffel D, Scott P, Shao X. Nuclear Medicine and Biology, 2023 Nov; 126: 108431 DOI:10.1016/j.nucmedbio.2023.108431
    • Journal Article
      P-301 Improved Synthesis of 3-[18F]Fluoro-p-Hydroxyphenethylguanidine ([18F]3F-PHPG) for Clinical Evaluation of Paraganglioma, Pheochromocytoma and Related Neuroendocrine Tumors
      Brooks A, Witek J, Scott P, Wong K, Viglianti B, Else T, Raffel D. Nuclear Medicine and Biology, 2023 Nov; 126: 108762 DOI:10.1016/j.nucmedbio.2023.108762