Associate Research Scientist
[email protected]
Available to mentor
Huira Chong Kopera, PhD
Associate Research Scientist
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Postdoctoral Research FellowUniversity of Michigan, Human Genetics, 2012
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Chung C, Yang X, Bae T, Vong KI, Mittal S, Donkels C, Westley Phillips H, Li Z, Marsh APL, Breuss MW, Ball LL, Garcia CAB, George RD, Gu J, Xu M, Barrows C, James KN, Stanley V, Nidhiry AS, Khoury S, Howe G, Riley E, Xu X, Copeland B, Wang Y, Kim SH, Kang H-C, Schulze-Bonhage A, Haas CA, Urbach H, Prinz M, Limbrick DD, Gurnett CA, Smyth MD, Sattar S, Nespeca M, Gonda DD, Imai K, Takahashi Y, Chen H-H, Tsai J-W, Conti V, Guerrini R, Devinsky O, Silva WA, Machado HR, Mathern GW, Abyzov A, Baldassari S, Baulac S, Focal Cortical Dysplasia Neurogenetics Consortium , Brain Somatic Mosaicism Network , Gleeson JG. Nat Genet, 2023 Feb; 55 (2): 209 - 220.Journal ArticleComprehensive multi-omic profiling of somatic mutations in malformations of cortical development.
DOI:10.1038/s41588-022-01276-9 PMID: 36635388 -
Yang X, Xu X, Breuss MW, Antaki D, Ball LL, Chung C, Shen J, Li C, George RD, Wang Y, Bae T, Cheng Y, Abyzov A, Wei L, Alexandrov LB, Sebat JL, NIMH Brain Somatic Mosaicism Network , Gleeson JG. Nat Biotechnol, 2023 Jun; 41 (6): 870 - 877.Journal ArticleControl-independent mosaic single nucleotide variant detection with DeepMosaic.
DOI:10.1038/s41587-022-01559-w PMID: 36593400 -
Breuss MW, Yang X, Schlachetzki JCM, Antaki D, Lana AJ, Xu X, Chung C, Chai G, Stanley V, Song Q, Newmeyer TF, Nguyen A, O'Brien S, Hoeksema MA, Cao B, Nott A, McEvoy-Venneri J, Pasillas MP, Barton ST, Copeland BR, Nahas S, Van Der Kraan L, Ding Y, NIMH Brain Somatic Mosaicism Network , Glass CK, Gleeson JG. Nature, 2022 Apr; 604 (7907): 689 - 696.Journal ArticleSomatic mosaicism reveals clonal distributions of neocortical development.
DOI:10.1038/s41586-022-04602-7 PMID: 35444276 -
Bae T, Fasching L, Wang Y, Shin JH, Suvakov M, Jang Y, Norton S, Dias C, Mariani J, Jourdon A, Wu F, Panda A, Pattni R, Chahine Y, Yeh R, Roberts RC, Huttner A, Kleinman JE, Hyde TM, Straub RE, Walsh CA, Brain Somatic Mosaicism Network§ , Urban AE, Leckman JF, Weinberger DR, Vaccarino FM, Abyzov A. Science, 2022 Jul 29; 377 (6605): 511 - 517.Journal ArticleAnalysis of somatic mutations in 131 human brains reveals aging-associated hypermutability.
DOI:10.1126/science.abm6222 PMID: 35901164 -
Aring L, Choi E-K, Kopera H, Lanigan T, Iwase S, Klionsky DJ, Seo YA. J Neurochem, 2022 Feb; 160 (3): 356 - 375.Journal ArticleA neurodegeneration gene, WDR45, links impaired ferritinophagy to iron accumulation.
DOI:10.1111/jnc.15548 PMID: 34837396 -
Wang Y, Bae T, Thorpe J, Sherman MA, Jones AG, Cho S, Daily K, Dou Y, Ganz J, Galor A, Lobon I, Pattni R, Rosenbluh C, Tomasi S, Tomasini L, Yang X, Zhou B, Akbarian S, Ball LL, Bizzotto S, Emery SB, Doan R, Fasching L, Jang Y, Juan D, Lizano E, Luquette LJ, Moldovan JB, Narurkar R, Oetjens MT, Rodin RE, Sekar S, Shin JH, Soriano E, Straub RE, Zhou W, Chess A, Gleeson JG, Marquès-Bonet T, Park PJ, Peters MA, Pevsner J, Walsh CA, Weinberger DR, Brain Somatic Mosaicism Network , Vaccarino FM, Moran JV, Urban AE, Kidd JM, Mills RE, Abyzov A. Genome Biol, 2021 Mar 29; 22 (1): 92Journal ArticleComprehensive identification of somatic nucleotide variants in human brain tissue.
DOI:10.1186/s13059-021-02285-3 PMID: 33781308 -
Bizzotto S, Dou Y, Ganz J, Doan RN, Kwon M, Bohrson CL, Kim SN, Bae T, Abyzov A, NIMH Brain Somatic Mosaicism Network , Park PJ, Walsh CA. Science, 2021 Mar 19; 371 (6535): 1249 - 1253.Journal ArticleLandmarks of human embryonic development inscribed in somatic mutations.
DOI:10.1126/science.abe1544 PMID: 33737485 -
Lanigan TM, Kopera HC, Saunders TL. Genes (Basel), 2020 Mar 10; 11 (3):Journal ArticlePrinciples of Genetic Engineering.
DOI:10.3390/genes11030291 PMID: 32164255
Department News
Department of Human Genetics faculty are involved in widely diverse areas of research, from Genome Structure and Function research to Evolutionary and Population Genetics.
Department News
Department of Human Genetics faculty are involved in widely diverse areas of research, from Genome Structure and Function research to Evolutionary and Population Genetics.