Jason A Heth
Professor of Neurosurgery
Professor of Otolaryngology-Head and Neck Surgery
Residency Assistant Director
Co-Director
CNS Tumor Registry and Medical Student Clerkship
[email protected]

Available to mentor
Jason A Heth
Clinical Professor
  • About
  • Qualifications
  • Research Overview
  • Recent Publications
    • About

    Dr. Heth joined the faculty at the University of Michigan Department of Neurosurgery in 2003. He was born in Iowa and primarily grew up in Iowa City. He attended the Johns Hopkins University and graduated with an undergraduate degree in Biomedical Engineering. He went to the University of Iowa for medical school and then residency. After spending a year in fellowship training with Osama Al-Mefty, MD, a pioneer in the field of skull base neurosurgery, Dr. Heth joined the faculty in 2003. He specializes in brain tumor surgery with particular interests in brain metastasis from systemic cancers, the effects of radiation treatment on the brain and brain metastasis, meningiomas, and skull base tumors. He has developed a strong interest in education and is very involved in medical student education, some specialized undergraduate programs, and residency training.

    Qualifications
    • Fellowship
      University of Arkansas for Medical Sciences, Neurosurgery, 2003
    Research Overview

    Brain metastasis and radiation necrosis/treatment effects on the CNS
    Educational initiatives in medical students and undergraduate students, particularly "first in family" students

    Recent Publications See All Publications
    • Journal Article
      Targeting fatty acid synthase in preclinical models of TNBC brain metastases synergizes with SN-38 and impairs invasion.
      Serhan HA, Bao L, Cheng X, Qin Z, Liu C-J, Heth JA, Udager AM, Soellner MB, Merajver SD, Morikawa A, Merrill NM. NPJ Breast Cancer, 2024 Jun 10; 10 (1): 43 DOI:10.1038/s41523-024-00656-0
      PMID: 38858374
    • Journal Article
      Abstract B051: DNA damage signaling activates GTP synthesis to promote glioblastoma treatment resistance
      Scott AJ, O'Brien A, Zhou W, Xu J, Palavalasa S, Kothari AU, Wilder-Romans K, Zhang L, Andren AC, Chandrasekaran S, Heth J, Umemura Y, Qi N, Lawrence TS, Al-Holou WN, Lyssiotis CA, Wahl DR. Cancer Research, 2024 Mar 4; 84 (5_Supplement_1): b051 - b051. DOI:10.1158/1538-7445.brain23-b051
    • Journal Article
      Milestones for neurosurgery sub-interns: a novel evaluation tool to quantitatively differentiate residency applicants.
      Bowden SG, Tan H, Rothbaum MG, Cook SH, Hanft S, Heth J, Morgenstern PF, Mullin JP, Orina JN, Wilson JL, Winer JL, Wolfe SQ, Chambless LB, Selden NR. J Neurosurg, 2023 Dec 1; 139 (6): 1748 - 1756. DOI:10.3171/2023.3.JNS23259
      PMID: 37148230
    • Journal Article
      BIOM-58. ZERO-WASTE MOLECULAR DIAGNOSTICS FROM BIOPSY NEEDLE WASHES
      Wadden J, John V, Niculcea M, Kong S, Aittaleb R, Cartaxo R, Verbal K, Bruzek A, Magge S, Yadavilli S, Erez N, Furth N, Shema E, Marapudi N, Heth J, Al-holou W, Garton H, Nazarian J, Koschmann C. Neuro-Oncology, 2023 Nov 10; 25 (Supplement_5): v17 - v18. DOI:10.1093/neuonc/noad179.0069
    • Proceeding / Abstract / Poster
      CTNI-61. MYCOPHENOLATE MOFETIL INHIBITS GLIOBLASTOMA PURINE METABOLISM IN HUMANS: AN INTERIM RESULT OF PHASE 0/1 CLINICAL TRIAL TO OVERCOME TREATMENT RESISTANCE IN NEWLY DIAGNOSED AND RECURRENT GLIOBLASTOMA
      Umemura Y, Al-Holou W, Elaimy A, Scott AJ, Leung D, Clarke N, Kim MM, Ferris S, Thomas J, Heth J, Schipper M, Suresh K, Lawrence T, Wahl D. Neuro-Oncology, 2023 Nov 10; 25 (Supplement_5): v90 - v90. DOI:10.1093/neuonc/noad179.0343
    • Journal Article
      Metabolomic Profiles of Human Glioma Inform Patient Survival.
      Scott AJ, Correa LO, Edwards DM, Sun Y, Ravikumar V, Andren AC, Zhang L, Srinivasan S, Jairath N, Verbal K, Muraszko K, Sagher O, Carty SA, Hervey-Jumper S, Orringer D, Kim MM, Junck L, Umemura Y, Leung D, Venneti S, Camelo-Piragua S, Lawrence TS, Ippolito JE, Al-Holou WN, Chinnaiyan P, Heth J, Rao A, Lyssiotis CA, Wahl DR. Antioxid Redox Signal, 2023 Nov; 39 (13-15): 942 - 956. DOI:10.1089/ars.2022.0085
      PMID: 36852494
    • Proceeding / Abstract / Poster
      A Phase 0 Study Assessing the Intracranial Activity of a Metabolic Radiosensitizer in Patients with Glioblastoma
      Elaimy AL, Al-Holou W, Scott A, Marini BL, Pai A, Wen B, Wang L, Sun D, Heth JA, Umemura Y, Wahl DR. International Journal of Radiation Oncology • Biology • Physics, 2023 Oct; 117 (2): e102 DOI:10.1016/j.ijrobp.2023.06.872
    • Journal Article
      Identification of Excellent Prognosis IDH Wildtype Glioblastomas Using Genomic and Metabolic Profiling
      Edwards DM, Hopkins A, Scott A, Mannan R, Cao X, Zhang L, Andren A, Heth JA, Muraszko K, Sagher O, Orringer D, Hollon T, Hervey-Jumper S, Venneti S, Camelo-Piragua S, Al-Holou W, Chinnaiyan A, Lyssiotis CA, Wahl DR. International Journal of Radiation Oncology • Biology • Physics, 2023 Oct; 117 (2): e101 DOI:10.1016/j.ijrobp.2023.06.870