Available to mentor
Gary B. Huffnagle, PhD, holds the Nina and Jerry D Luptak Professorship in the Mary H. Weiser Food Allergy Center at the University of Michigan. He received his BS in microbiology from Penn State University and PhD in immunology from the University of Texas Southwestern Medical School. He has been a faculty member at the University of Michigan since completing his post-doctoral fellowship at UT Southwestern and teaches a series of courses in microbial pathogenesis, host immunity, bacteriology, microbial genomics, and allergic diseases to students ranging from sophomore undergraduates to graduate students.
He and his collaborators have published over 250 peer-reviewed publications and his laboratory has provided mentorship for more than 50 undergraduates, 20 graduate students and 15 post-doctoral fellows during his career. Dr. Huffnagle has served as an Associate Chair of Undergraduate Studies in the Department of MCDB and Interim Director of the Immunology Graduate Program. Dr. Huffnagle has been a frequent study section reviewer for the National Institutes of Health, including standing membership for multiple study sections, and has presented over 150 invited national and international lectures and talks. In 2007, he published "The Probiotics Revolution," a book aimed at introducing the topic of the human microbiome in disease to the general public. In 2014, "The Lancet" wrote a feature biography on him titled "Rewriting the Rules on the Lung Microbiome." In recognition of his efforts in both research and education, Dr. Huffnagle was awarded a Faculty Recognition Award from the President's and Provost's Offices at the University of Michigan in 2010 and he was elected to the American Academy of Microbiology of the American Society for Microbiology in 2013.
Huffnagle Lab
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BSPennsylvania State University (Honors in Microbiology), University Park
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PhDUniversity of Texas Southwestern Medical Center, Dallas
The research focus of the Huffnagle laboratory is on the interplay between elements of mucosal immunity, the microbiome, pathogens, and other aspects of physiology as they relate to food allergies, inflammation, infection, and health. This includes studies of the respiratory and gastrointestinal mucosa. Our laboratory utilizes an interdisciplinary approach that combines research approaches in pathophysiology, immunology, microbiology, microbial ecology, microbial genomics and computational biology. Current projects in the lab include studies of host-microbiome interactions at a molecular/cellular level, in both human disease and mouse models of inflammation/infection and food allergy.
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Zeise KD, Falkowski NR, Metcalf JD, Brown CA, Huffnagle GB. Infect Immun, 2024 Nov 13; e0043824Journal ArticleGene expression profiling reveals host defense strategies for restricting Candida albicans invasion and gastritis to the limiting ridge of the murine stomach.
DOI:10.1128/iai.00438-24 PMID: 39535200 -
Zeise KD, Falkowski NR, Stark KG, Brown CA, Huffnagle GB. mBio, 2024 Nov 13; 15 (11): e0211324Journal ArticleProfiling inflammatory outcomes of Candida albicans colonization and food allergy induction in the murine glandular stomach.
DOI:10.1128/mbio.02113-24 PMID: 39347572 -
Yagi K, Ethridge AD, Falkowski NR, Huang YJ, Elesela S, Huffnagle GB, Lukacs NW, Fonseca W, Asai N. Am J Physiol Lung Cell Mol Physiol, 2024 Nov 1; 327 (5): L646 - L660.Journal ArticleMicrobiome modifications by steroids during viral exacerbation of asthma and in healthy mice.
DOI:10.1152/ajplung.00040.2024 PMID: 39159427 -
Baker J, Flott T, Mclellan L, Falkowski N, Huffnagle G, Stringer K, Dickson R. 2024 Sep 14; pa2396Proceeding / Abstract / PosterThe impact of differential nutrient availability during acute lung injury on Pseudomonas aeruginosa growth
DOI:10.1183/13993003.congress-2024.pa2396 -
Ravi K, Oh GJ, Moore BB, Huffnagle GB, Zhou X. Microbiol Resour Announc, 2024 Sep 10; 13 (9): e0055524Journal ArticleGenome sequence of Lactobacillus johnsonii XZ17, isolated from a C57BL/6J mouse lung.
DOI:10.1128/mra.00555-24 PMID: 39162468 -
Opron K, Begley LA, Erb-Downward JR, Li G, Alexis NE, Barjaktarevic I, Barr RG, Bleecker ER, Boucher R, Bowler RP, Christenson SA, Comellas AP, Criner G, Cooper CB, Couper D, Galban CJ, Han MK, Hastie A, Hatt C, Hoffman EA, Kaner RJ, Kesimer M, Krishnan JA, LaFon DC, Martinez FJ, Ortega VE, Peters SP, Paine R, Putcha N, Woodruff PG, Huffnagle GB, Kozik AJ, Curtis JL, Huang YJ, SPIROMICS Investigators . Am J Respir Crit Care Med, 2024 Jul 15; 210 (2): 186 - 200.Journal ArticleLoss of Airway Phylogenetic Diversity Is Associated with Clinical and Pathobiological Markers of Disease Development in Chronic Obstructive Pulmonary Disease.
DOI:10.1164/rccm.202303-0489OC PMID: 38261629 -
Perkins J, Ravi K, Guo C, Oh G, Rodriguez B, Gurczynski S, Weinberg J, Huffnagle G, O’Dwyer D, Moore B, Zhou X. 2024 bioRxiv,PreprintLung Microbiome Intervention Attenuates Herpesvirus-Induced Post-HCT Pulmonary Fibrosis Through PD-L1 Upregulation on Dendritic Cells
DOI:10.1101/2024.07.06.602351 -
Gestal MC, Oates AE, Akob DM, Criss AK, Host-Microbe Retreat Planning Committee , Host-Microbe Retreat Speakers . mSphere, 2024 Jul 30; 9 (7): e0025624Journal ArticlePerspectives on the future of host-microbe biology from the Council on Microbial Sciences of the American Society for Microbiology.
DOI:10.1128/msphere.00256-24 PMID: 38920371