Gary B Huffnagle, PhD
Nina and Jerry D Luptak Research Professor
Research Professor
Mary H Weiser Food Allergy Center
Professor of Internal Medicine
Professor of Microbiology and Immunology
Professor of Molecular, Cellular and Developmental Biology
College of Literature, Science, and the Arts
[email protected]

Available to mentor

Gary B Huffnagle, PhD
Professor
  • About
  • Links
  • Qualifications
  • Research Overview
  • Recent Publications
  • About

    Gary B. Huffnagle, PhD, holds the Nina and Jerry D Luptak Professorship in the Mary H. Weiser Food Allergy Center at the University of Michigan. He received his BS in microbiology from Penn State University and PhD in immunology from the University of Texas Southwestern Medical School. He has been a faculty member at the University of Michigan since completing his post-doctoral fellowship at UT Southwestern and teaches a series of courses in microbial pathogenesis, host immunity, bacteriology, microbial genomics, and allergic diseases to students ranging from sophomore undergraduates to graduate students.

    He and his collaborators have published over 250 peer-reviewed publications and his laboratory has provided mentorship for more than 50 undergraduates, 20 graduate students and 15 post-doctoral fellows during his career. Dr. Huffnagle has served as an Associate Chair of Undergraduate Studies in the Department of MCDB and Interim Director of the Immunology Graduate Program. Dr. Huffnagle has been a frequent study section reviewer for the National Institutes of Health, including standing membership for multiple study sections, and has presented over 150 invited national and international lectures and talks. In 2007, he published "The Probiotics Revolution," a book aimed at introducing the topic of the human microbiome in disease to the general public. In 2014, "The Lancet" wrote a feature biography on him titled "Rewriting the Rules on the Lung Microbiome." In recognition of his efforts in both research and education, Dr. Huffnagle was awarded a Faculty Recognition Award from the President's and Provost's Offices at the University of Michigan in 2010 and he was elected to the American Academy of Microbiology of the American Society for Microbiology in 2013.

    Links
    • Huffnagle Lab
    Qualifications
    • BS
      Pennsylvania State University (Honors in Microbiology), University Park
    • PhD
      University of Texas Southwestern Medical Center, Dallas
    Research Overview

    The research focus of the Huffnagle laboratory is on the interplay between elements of mucosal immunity, the microbiome, pathogens, and other aspects of physiology as they relate to food allergies, inflammation, infection, and health. This includes studies of the respiratory and gastrointestinal mucosa. Our laboratory utilizes an interdisciplinary approach that combines research approaches in pathophysiology, immunology, microbiology, microbial ecology, microbial genomics and computational biology. Current projects in the lab include studies of host-microbiome interactions at a molecular/cellular level, in both human disease and mouse models of inflammation/infection and food allergy.

    Recent Publications See All Publications
    • Journal Article
      Gene expression profiling reveals host defense strategies for restricting Candida albicans invasion and gastritis to the limiting ridge of the murine stomach.
      Zeise KD, Falkowski NR, Metcalf JD, Brown CA, Huffnagle GB. Infect Immun, 2024 Nov 13; e0043824 DOI:10.1128/iai.00438-24
      PMID: 39535200
    • Journal Article
      Profiling inflammatory outcomes of Candida albicans colonization and food allergy induction in the murine glandular stomach.
      Zeise KD, Falkowski NR, Stark KG, Brown CA, Huffnagle GB. mBio, 2024 Nov 13; 15 (11): e0211324 DOI:10.1128/mbio.02113-24
      PMID: 39347572
    • Journal Article
      Microbiome modifications by steroids during viral exacerbation of asthma and in healthy mice.
      Yagi K, Ethridge AD, Falkowski NR, Huang YJ, Elesela S, Huffnagle GB, Lukacs NW, Fonseca W, Asai N. Am J Physiol Lung Cell Mol Physiol, 2024 Nov 1; 327 (5): L646 - L660. DOI:10.1152/ajplung.00040.2024
      PMID: 39159427
    • Proceeding / Abstract / Poster
      The impact of differential nutrient availability during acute lung injury on Pseudomonas aeruginosa growth
      Baker J, Flott T, Mclellan L, Falkowski N, Huffnagle G, Stringer K, Dickson R. 2024 Sep 14; pa2396 DOI:10.1183/13993003.congress-2024.pa2396
    • Journal Article
      Genome sequence of Lactobacillus johnsonii XZ17, isolated from a C57BL/6J mouse lung.
      Ravi K, Oh GJ, Moore BB, Huffnagle GB, Zhou X. Microbiol Resour Announc, 2024 Sep 10; 13 (9): e0055524 DOI:10.1128/mra.00555-24
      PMID: 39162468
    • Journal Article
      Loss of Airway Phylogenetic Diversity Is Associated with Clinical and Pathobiological Markers of Disease Development in Chronic Obstructive Pulmonary Disease.
      Opron K, Begley LA, Erb-Downward JR, Li G, Alexis NE, Barjaktarevic I, Barr RG, Bleecker ER, Boucher R, Bowler RP, Christenson SA, Comellas AP, Criner G, Cooper CB, Couper D, Galban CJ, Han MK, Hastie A, Hatt C, Hoffman EA, Kaner RJ, Kesimer M, Krishnan JA, LaFon DC, Martinez FJ, Ortega VE, Peters SP, Paine R, Putcha N, Woodruff PG, Huffnagle GB, Kozik AJ, Curtis JL, Huang YJ, SPIROMICS Investigators . Am J Respir Crit Care Med, 2024 Jul 15; 210 (2): 186 - 200. DOI:10.1164/rccm.202303-0489OC
      PMID: 38261629
    • Preprint
      Lung Microbiome Intervention Attenuates Herpesvirus-Induced Post-HCT Pulmonary Fibrosis Through PD-L1 Upregulation on Dendritic Cells
      Perkins J, Ravi K, Guo C, Oh G, Rodriguez B, Gurczynski S, Weinberg J, Huffnagle G, O’Dwyer D, Moore B, Zhou X. 2024 bioRxiv, DOI:10.1101/2024.07.06.602351
    • Journal Article
      Perspectives on the future of host-microbe biology from the Council on Microbial Sciences of the American Society for Microbiology.
      Gestal MC, Oates AE, Akob DM, Criss AK, Host-Microbe Retreat Planning Committee , Host-Microbe Retreat Speakers . mSphere, 2024 Jul 30; 9 (7): e0025624 DOI:10.1128/msphere.00256-24
      PMID: 38920371
    Featured News & Stories Dr. Bob Dickson receives the Toew's award
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    Dr. Bob Dickson is named the Galen B. Toews MD Legacy Professor in Pulmonary and Critical Care Medicine
    Dickson joined the faculty of the Division of Pulmonary and Critical Care Medicine in 2015 and was promoted to Associate Professor in 2020. He is the program director for the Pulmonary T32 program. Dickson also holds an appointment in the Department of Microbiology and Immunology and serves as deputy director of the Weil Institute for Critical Care Research and Innovation.
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    Jennifer Baker, PhD Candidate: Running the PhD marathon
    Jennifer Baker is a PhD Candidate in the Microbiology & Immunology Program.