Gary B Huffnagle, PhD
Nina and Jerry D Luptak Research Professor
Research Professor
Mary H Weiser Food Allergy Center
Professor of Internal Medicine
Professor of Microbiology and Immunology
Professor of Molecular, Cellular and Developmental Biology
College of Literature, Science, and the Arts
[email protected]

Available to mentor

Gary B Huffnagle, PhD
  • About
  • Links
  • Qualifications
  • Research Overview
  • Recent Publications
  • About

    Gary B. Huffnagle, PhD, holds the Nina and Jerry D Luptak Professorship in the Mary H. Weiser Food Allergy Center at the University of Michigan. He received his BS in microbiology from Penn State University and PhD in immunology from the University of Texas Southwestern Medical School. He has been a faculty member at the University of Michigan since completing his post-doctoral fellowship at UT Southwestern and teaches a series of courses in microbial pathogenesis, host immunity, bacteriology, microbial genomics, and allergic diseases to students ranging from sophomore undergraduates to graduate students.

    He and his collaborators have published over 250 peer-reviewed publications and his laboratory has provided mentorship for more than 50 undergraduates, 20 graduate students and 15 post-doctoral fellows during his career. Dr. Huffnagle has served as an Associate Chair of Undergraduate Studies in the Department of MCDB and Interim Director of the Immunology Graduate Program. Dr. Huffnagle has been a frequent study section reviewer for the National Institutes of Health, including standing membership for multiple study sections, and has presented over 150 invited national and international lectures and talks. In 2007, he published "The Probiotics Revolution," a book aimed at introducing the topic of the human microbiome in disease to the general public. In 2014, "The Lancet" wrote a feature biography on him titled "Rewriting the Rules on the Lung Microbiome." In recognition of his efforts in both research and education, Dr. Huffnagle was awarded a Faculty Recognition Award from the President's and Provost's Offices at the University of Michigan in 2010 and he was elected to the American Academy of Microbiology of the American Society for Microbiology in 2013.

    • Huffnagle Lab
    • BS
      Pennsylvania State University (Honors in Microbiology), University Park
    • PhD
      University of Texas Southwestern Medical Center, Dallas
    Research Overview

    The research focus of the Huffnagle laboratory is on the interplay between elements of mucosal immunity, the microbiome, pathogens, and other aspects of physiology as they relate to food allergies, inflammation, infection, and health. This includes studies of the respiratory and gastrointestinal mucosa. Our laboratory utilizes an interdisciplinary approach that combines research approaches in pathophysiology, immunology, microbiology, microbial ecology, microbial genomics and computational biology. Current projects in the lab include studies of host-microbiome interactions at a molecular/cellular level, in both human disease and mouse models of inflammation/infection and food allergy.

    Recent Publications See All Publications
    • Journal Article
      Respiratory and Gut Microbiome Modification during Respiratory Syncytial Virus Infection: A Systematic Review.
      Yagi K, Lukacs NW, Huffnagle GB, Kato H, Asai N. Viruses, 2024 Jan 31; 16 (2): DOI:10.3390/v16020220
      PMID: 38399997
    • Journal Article
      Loss of Airway Phylogenetic Diversity Is Associated with Clinical and Pathobiological Markers of Disease Development in COPD.
      Opron K, Begley LA, Erb-Downward JR, Li G, Alexis NE, Barjaktarevic I, Barr RG, Bleecker ER, Boucher R, Bowler RP, Christenson SA, Comellas AP, Criner G, Cooper CB, Couper D, Galban CJ, Han MK, Hastie A, Hatt C, Hoffman EA, Kaner RJ, Kesimer M, Krishnan JA, LaFon DC, Martinez FJ, Ortega VE, Peters SP, Paine Iii R, Putcha N, Woodruff PG, Huffnagle GB, Kozik AJ, Curtis JL, Huang YJ, SPIROMICS Investigators . Am J Respir Crit Care Med, 2024 Jan 23; DOI:10.1164/rccm.202303-0489OC
      PMID: 38261629
    • Journal Article
      Lactobacillus johnsonii and host communication: insight into modulatory mechanisms during health and disease
      Arzola-Martínez L, Ravi K, Huffnagle GB, Lukacs NW, Fonseca W. Frontiers in Microbiomes, 2: 1345330 DOI:10.3389/frmbi.2023.1345330
    • Journal Article
      Horizontal transmission of gut microbiota attenuates mortality in lung fibrosis.
      Gurczynski SJ, Lipinski JH, Strauss J, Alam S, Huffnagle GB, Ranjan P, Kennedy LH, Moore BB, O'Dwyer DN. JCI Insight, 2023 Nov 28; 9 (1): DOI:10.1172/jci.insight.164572
      PMID: 38015634
    • Proceeding / Abstract / Poster
      ASAI N, ETHRIDGE AD, FONSECA W, YAGI K, RASKY A, MORRIS S, FALKOWSKI N, HUANG YJ, HUFFNAGLE G, LUKACS N. CHEST Journal, 2023 Oct; 164 (4): a56 DOI:10.1016/j.chest.2023.07.095
    • Journal Article
      A steroid-resistant cockroach allergen model is associated with lung and cecal microbiome changes.
      Asai N, Ethridge AD, Fonseca W, Yagi K, Rasky AJ, Morris SB, Falkowski NR, Huang YJ, Huffnagle GB, Lukacs NW. Physiol Rep, 2023 Jul; 11 (13): e15761 DOI:10.14814/phy2.15761
      PMID: 37403414
    • Proceeding / Abstract / Poster
      Alveolar Neutrophilia Is Temporally Correlated With Staphylococcal Outgrowth, Not Pulmonary Injury, Following Hyperoxia Exposure
      Mayoras B, Rosenthal B, Ashley SL, Luth J, Fergle D, Falkowski N, Brown C, Huffnagle GB, Dickson RP, Baker JM. 2023 May; a2098 - a2098. DOI:10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a2098
    • Proceeding / Abstract / Poster
      Anti-Anaerobic Antibiotics Contribute to Liver Injury and Metabolic Dysfunction in a Murine Model of Oxygen Toxicity
      Metcalf JD, Baker JM, McLellan L, Flott T, Chanderraj R, McDonald RA, Falkowski NR, Huffnagle GB, Stringer KA, Dickson RP. 2023 May; a6067 - a6067. DOI:10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6067