My primary research interest focuses on biochemical mechanisms of chemokine and growth factor signaling in the breast cancer primary and metastatic tumor environment, and how these regulate breast cancer progression and response to therapy. As a key element of this work, I develop innovative fluorescence and bioluminescence approaches, including integrated systems of luciferase protein fragment complementation and kinase translocation reporters. I am a research specialist in molecular imaging of cell signaling, and I work in a large collaborative network of physicians, biologists, engineers, and computational experts across multiple institutions. We detect and quantify intercellular and intracellular signaling events at the single cell level. From hundreds to millions of single cell observations, we use a variety of approaches to construct multiscale models of intracellular signaling pathways and the tumor environment. Other ongoing projects I am involved in examine cell signaling in myelofibrosis and other cancers, including decoding the functions of GIV in cancer cell states and autocrine/paracrine signaling.

Breast cancer tumor microenvironment, chemokine and growth factor signaling in cancer, autocrine/paracrine signaling in cancer, bioluminescence and fluorescence reporters of cell signaling, custom image analysis methods, multiscale computational modeling of cancer cell signaling environments.