Jochen H Schacht
Professor Emeritus of Otolaryngology-Head and Neck Surgery
[email protected]

Available to mentor
Jochen H Schacht
Center Member
  • Center Memberships
  • Recent Publications
    • Center Memberships
    • Center Member
      Kresge Hearing Research Institute
    Recent Publications See All Publications
    • Journal Article
      Phenotype of Mrps5-Associated Phylogenetic Polymorphisms Is Intimately Linked to Mitoribosomal Misreading.
      Juskeviciene R, Fritz A-K, Brilkova M, Akbergenov R, Schmitt K, Rehrauer H, Laczko E, Isnard-Petit P, Thiam K, Eckert A, Schacht J, Wolfer DP, Böttger EC, Shcherbakov D. Int J Mol Sci, 2022 Apr 15; 23 (8): DOI:10.3390/ijms23084384
      PMID: 35457201
    • Journal Article
      An Advanced Apralog with Increased in vitro and in vivo Activity toward Gram-negative Pathogens and Reduced ex vivo Cochleotoxicity.
      Sonousi A, Quirke JCK, Waduge P, Janusic T, Gysin M, Haldimann K, Xu S, Hobbie SN, Sha S-H, Schacht J, Chow CS, Vasella A, Böttger EC, Crich D. ChemMedChem, 2021 Jan 19; 16 (2): 335 - 339. DOI:10.1002/cmdc.202000726
      PMID: 33007139
    • Journal Article
      Apralogs: Apramycin 5-O-Glycosides and Ethers with Improved Antibacterial Activity and Ribosomal Selectivity and Reduced Susceptibility to the Aminoacyltranserferase (3)-IV Resistance Determinant.
      Quirke JCK, Rajasekaran P, Sarpe VA, Sonousi A, Osinnii I, Gysin M, Haldimann K, Fang Q-J, Shcherbakov D, Hobbie SN, Sha S-H, Schacht J, Vasella A, Böttger EC, Crich D. J Am Chem Soc, 2020 Jan 8; 142 (1): 530 - 544. DOI:10.1021/jacs.9b11601
      PMID: 31790244
    • Journal Article
      Auditory metabolomics, an approach to identify acute molecular effects of noise trauma.
      Ji L, Lee H-J, Wan G, Wang G-P, Zhang L, Sajjakulnukit P, Schacht J, Lyssiotis CA, Corfas G. Sci Rep, 2019 Jun 25; 9 (1): 9273 DOI:10.1038/s41598-019-45385-8
      PMID: 31239523
    • Journal Article
      Design, Multigram Synthesis, and in Vitro and in Vivo Evaluation of Propylamycin: A Semisynthetic 4,5-Deoxystreptamine Class Aminoglycoside for the Treatment of Drug-Resistant Enterobacteriaceae and Other Gram-Negative Pathogens.
      Matsushita T, Sati GC, Kondasinghe N, Pirrone MG, Kato T, Waduge P, Kumar HS, Sanchon AC, Dobosz-Bartoszek M, Shcherbakov D, Juhas M, Hobbie SN, Schrepfer T, Chow CS, Polikanov YS, Schacht J, Vasella A, Böttger EC, Crich D. J Am Chem Soc, 2019 Mar 27; 141 (12): 5051 - 5061. DOI:10.1021/jacs.9b01693
      PMID: 30793894
    • Journal Article
      Mutant MRPS5 affects mitoribosomal accuracy and confers stress-related behavioral alterations.
      Akbergenov R, Duscha S, Fritz A-K, Juskeviciene R, Oishi N, Schmitt K, Shcherbakov D, Teo Y, Boukari H, Freihofer P, Isnard-Petit P, Oettinghaus B, Frank S, Thiam K, Rehrauer H, Westhof E, Schacht J, Eckert A, Wolfer D, Böttger EC. EMBO Rep, 2018 Nov; 19 (11): DOI:10.15252/embr.201846193
      PMID: 30237157
    • Journal Article
      Assessing ototoxicity due to chronic lead and cadmium intake with and without noise exposure in the mature mouse.
      Carlson K, Schacht J, Neitzel RL. J Toxicol Environ Health A, 2018 81 (20): 1041 - 1057. DOI:10.1080/15287394.2018.1521320
      PMID: 30239325
    • Journal Article
      Effects of the 1- N-(4-Amino-2 S-hydroxybutyryl) and 6'- N-(2-Hydroxyethyl) Substituents on Ribosomal Selectivity, Cochleotoxicity, and Antibacterial Activity in the Sisomicin Class of Aminoglycoside Antibiotics.
      Sonousi A, Sarpe VA, Brilkova M, Schacht J, Vasella A, Böttger EC, Crich D. ACS Infect Dis, 2018 Jul 13; 4 (7): 1114 - 1120. DOI:10.1021/acsinfecdis.8b00052
      PMID: 29708331