Associate Research Scientist
Pharmacology
[email protected]
Available to mentor
Yoshihiro Morishima, MD, PhD
Associate Research Scientist
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Felker D, Lee K, Pospiech TH, Morishima Y, Zhang H, Lau M, Southworth DR, Osawa Y. J Biol Chem, 2024 Jan; 300 (1): 105464Journal ArticleMapping interactions of calmodulin and neuronal NO synthase by crosslinking and mass spectrometry.
DOI:10.1016/j.jbc.2023.105464 PMID: 37979917 -
Morishima Y, Lau M, Pratt WB, Osawa Y. J Biol Chem, 2023 Feb; 299 (2): 102856Journal ArticleDynamic cycling with a unique Hsp90/Hsp70-dependent chaperone machinery and GAPDH is needed for heme insertion and activation of neuronal NO synthase.
DOI:10.1016/j.jbc.2022.102856 PMID: 36596358 -
Felker D, Zhang H, Bo Z, Lau M, Morishima Y, Schnell S, Osawa Y. Biophys Chem, 2021 Jul; 274: 106590Journal ArticleMapping protein-protein interactions in homodimeric CYP102A1 by crosslinking and mass spectrometry.
DOI:10.1016/j.bpc.2021.106590 PMID: 33894563 -
Mehta RK, Pal S, Kondapi K, Sitto M, Dewar C, Devasia T, Schipper MJ, Thomas DG, Basrur V, Pai MP, Morishima Y, Osawa Y, Pratt WB, Lawrence TS, Nyati MK. Clin Cancer Res, 2020 Oct 1; 26 (19): 5246 - 5257.Journal ArticleLow-Dose Hsp90 Inhibitor Selectively Radiosensitizes HNSCC and Pancreatic Xenografts.
DOI:10.1158/1078-0432.CCR-19-3102 PMID: 32718999 -
Davis AK, McMyn NF, Lau M, Morishima Y, Osawa Y. Mol Pharmacol, 2020 Sep; 98 (3): 243 - 249.Journal ArticleHsp70:CHIP Ubiquitinates Dysfunctional but Not Native Neuronal NO Synthase.
DOI:10.1124/mol.120.119990 PMID: 32591478 -
Mehta RK, Pal S, Kondapi K, Sitto M, Dewar C, Devasia T, Schipper MJ, Dafydd TG, Basrur V, Pai MP, Morishima Y, Osawa Y, Pratt WB, Lawrence TS, Nyati MK. Clinical Cancer Research, 2020 Jan 1; 26 (19):Journal ArticleLow-dose Hsp90 inhibitor selectivity radiosensitizes HNSCC and pancreatic xenografts.
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Pospiech TH, Morishima Y, Osawa Y, Southworth DR. Biophysical Journal, 2019 Feb; 116 (3): 187a - 188a.Proceeding / Abstract / PosterCryo-EM Structural Analysis of Neuronal Nitric Oxide Synthase
DOI:10.1016/j.bpj.2018.11.1040 -
Morishima Y, Mehta RK, Yoshimura M, Lau M, Southworth DR, Lawrence TS, Pratt WB, Nyati MK, Osawa Y. Molecular Pharmacology, 2018 Jun 25; 94: 984 - 991.Journal ArticleChaperone Activity and Dimerization Properties of Hsp90α and Hsp90β in Glucocorticoid Receptor Activation by the Multiprotein Hsp90/Hsp70-Dependent Chaperone Machinery
Department News
Dr. Yoshihiro Morishima, in the U-M Medical School Department of Pharmacology, has received "Best Abstract."
