Available to mentor
Weizhen Zhang, MD, PhD, is a Research Professor at the Department of Surgery, the University of Michigan. Dr. Zhang received his bachelors in medicine from Sun Yat-sen University of Medical Sciences in 1987, and Ph.D. from Beijing Medical University in 1994. Dr. Zhang is the author of over 140 peer-reviewed manuscripts in prestigious journal such as Hepatology, Nature Communications, PNAS and Diabetes. He has been invited to serve as a reviewer for many journals and funding agencies including NSFC and ADA, to deliver numerous visiting professor lectures and presentations. He has been serving as editor-in-chief of three journals and editor board member of three other journals.
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Center MemberCaswell Diabetes Institute
Dr. Zhang's research focuses on defining the mechanisms by which gut interacts with metabolic organs to regulate glucose and lipid metabolism. He is the pioneer in the definition of gastric fuel sensing mechanism. His works unravel the mechanism by which gastric endocrine cells sense the fuel supply to coordinate the production of gastric hormones with fuel status at the organism levels. The gastric hormones then function to modulate the food intake as well as glucose and lipid homeostasis.
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Liang Y, Luo C, Sun L, Feng T, Yin W, Zhang Y, Mulholland MW, Zhang W, Yin Y. Nat Commun, 2024 May 23; 15 (1): 4393Journal ArticleReduction of specific enterocytes from loss of intestinal LGR4 improves lipid metabolism in mice.
DOI:10.1038/s41467-024-48622-5 PMID: 38782937 -
Lv Y, Lu X, Liu G, Qi L, Zhong Z, Wang X, Zhang W, Shi R, Goodarzi MO, Pandol SJ, Li L. J Clin Endocrinol Metab, 2024 Jul 12; 109 (8): 2003 - 2011.Journal ArticleDifferential Diagnosis of Post Pancreatitis Diabetes Mellitus Based on Pancreatic and Gut Hormone Characteristics.
DOI:10.1210/clinem/dgae080 PMID: 38344778 -
Bi Y, Zhang L, Song Y, Sun L, Mulholland MW, Yin Y, Zhang W. Gastroenterol Hepatol, 2024 Apr; 47 (4): 352 - 365.Journal ArticleRspo2-LGR4 exacerbates hepatocellular carcinoma progression via activation of Wnt/β-catenin signaling pathway.
DOI:10.1016/j.gastrohep.2023.05.016 PMID: 37437654 -
Bi Y, Zhang L, Song Y, Sun L, Mulholland MW, Yin Y, Zhang W. Gastroenterología y Hepatología (English Edition), 2024 Apr; 47 (4): 352 - 365.Journal ArticleRspo2-LGR4 exacerbates hepatocellular carcinoma progression via activation of Wnt/β-catenin signaling pathway
DOI:10.1016/j.gastre.2023.05.018 -
Chen H, Sun L, Feng L, Han X, Zhang Y, Zhai W, Zhang Z, Mulholland M, Zhang W, Yin Y. eLife, 12:Journal ArticleIntermittent fasting promotes type 3 innate lymphoid cells secreting IL-22 contributing to the beigeing of white adipose tissue
DOI:10.7554/elife.91060.3 -
Zhao Y, Liu Y, Tao T, Zhang J, Guo W, Deng H, Han M, Mo H, Tong X, Lin S, Yang J, Zhai H, Wang Q, Hu Z, Zhang W, Chen H, Xu G. Nat Metab, 2024 Mar; 6 (3): 458 - 472.Journal ArticleGastric mechanosensitive channel Piezo1 regulates ghrelin production and food intake.
DOI:10.1038/s42255-024-00995-z PMID: 38467889 -
Chen H, Sun L, Feng L, Han X, Zhang Y, Zhai W, Zhang Z, Mulholland M, Zhang W, Yin Y. Elife, 2024 Mar 27; 12:Journal ArticleIntermittent fasting promotes type 3 innate lymphoid cells secreting IL-22 contributing to the beigeing of white adipose tissue.
DOI:10.7554/eLife.91060 PMID: 38536726 -
Chen H, Sun L, Feng L, Han X, Zhang Y, Zhai W, Zhang Z, Mulholland M, Zhang W, Yin Y. 2024 Jan 10;PreprintIntermittent fasting promotes ILC3s secreting IL-22 contributing to the beigeing of white adipose tissue.
DOI:10.1101/2023.08.29.555436 PMID: 37693430
