Associate Research Scientist
Internal Medicine
[email protected]
Available to mentor
Sangchoul Im
Associate Research Scientist
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Center MemberCenter for Integrative Research in Critical Care
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Loomis CL, Im S-C, Scott EE. RSC Chem Biol, 2024 Aug 2; 5 (9): 938 - 951.Journal ArticleAdrenodoxin allosterically alters human cytochrome P450 11B enzymes to accelerate substrate binding and decelerate release.
DOI:10.1039/d4cb00015c PMID: 39129792 -
Valentín-Goyco J, Im S-C, Auchus RJ. Biochemistry, 2024 Apr 16; 63 (8): 1026 - 1037.Journal ArticleKinetics of Intermediate Release Enhances P450 11B2-Catalyzed Aldosterone Synthesis.
DOI:10.1021/acs.biochem.3c00725 PMID: 38564530 -
Krishnarjuna B, Sharma G, Im S-C, Auchus R, Anantharamaiah GM, Ramamoorthy A. J Colloid Interface Sci, 2024 Jan; 653 (Pt B): 1402 - 1414.Journal ArticleCharacterization of nanodisc-forming peptides for membrane protein studies.
DOI:10.1016/j.jcis.2023.09.162 PMID: 37801850 -
Sumangala N, Im S-C, Valentín-Goyco J, Auchus RJ. J Inorg Biochem, 2023 Oct; 247: 112340Journal ArticleInfluence of cholesterol on kinetic parameters for human aromatase (P450 19A1) in phospholipid nanodiscs.
DOI:10.1016/j.jinorgbio.2023.112340 PMID: 37544101 -
Im S-C, Valentín-Goyco J, Peng H-M, Auchus RJ. Methods Enzymol, 2023 689: 263 - 276.Journal ArticleBacterial expression, purification, and reconstitution of human steroid 5α-reductases in phospholipid liposomes and nanodiscs.
DOI:10.1016/bs.mie.2023.05.005 PMID: 37802573 -
Krishnarjuna B, Im S-C, Ravula T, Marte J, Auchus RJ, Ramamoorthy A. Anal Chem, 2022 Aug 30; 94 (34): 11908 - 11915.Journal ArticleNon-Ionic Inulin-Based Polymer Nanodiscs Enable Functional Reconstitution of a Redox Complex Composed of Oppositely Charged CYP450 and CPR in a Lipid Bilayer Membrane.
DOI:10.1021/acs.analchem.2c02489 PMID: 35977417 -
Rwere F, Im S, Waskell L. Int J Mol Sci, 2021 Sep 30; 22 (19):Journal ArticleThe FMN "140s Loop" of Cytochrome P450 Reductase Controls Electron Transfer to Cytochrome P450.
DOI:10.3390/ijms221910625 PMID: 34638963 -
Bai J, Wang J, Ravula T, Im S-C, Anantharamaiah GM, Waskell L, Ramamoorthy A. Biochim Biophys Acta Biomembr, 2020 May 1; 1862 (5): 183194Journal ArticleExpression, purification, and functional reconstitution of 19F-labeled cytochrome b5 in peptide nanodiscs for NMR studies.
DOI:10.1016/j.bbamem.2020.183194 PMID: 31953231