Jason Robert Spence, PhD
H Marvin Pollard Collegiate Professor of Gastrointestinal Sciences
Professor of Internal Medicine
Professor of Cell and Developmental Biology
Professor of Biomedical Engineering
[email protected]

Available to mentor
Jason Robert Spence, PhD
Professor
  • Center Memberships
  • Research Overview
  • Recent Publications
    • Center Memberships
    • Center Member
      Biosciences Initiative
    • Center Member
      Center for Cell Plasticity and Organ Design
    • Center Member
      Caswell Diabetes Institute
    • Center Member
      Rogel Cancer Center
    Research Overview

    1. Developmental Biology: Using model organisms and human tissue to understand mechanisms by which the
    embryo develops, with a focus on specification, differentiation and organogenesis of tissue derived from the
    endoderm.
    2. Stem Cell Biology, Regenerative Medicine and Disease Modeling: Directing differentiation of human
    pluripotent stem cells into different endodermal lineages such that we may generate tissue for replacement
    therapies and discover novel in vitro methods to model and study human development and disease.

    Recent Publications See All Publications
    • Journal Article
      Polymer Design of Microwell Hydrogels Influences Epithelial–Mesenchymal Interactions During Human Bronchosphere Formation
      Eiken MK, Levine JE, Lee S, Lukpat S, Plaster EM, Bala V, Spence JR, Loebel C. Advanced NanoBiomed Research, DOI:10.1002/anbr.202300110
    • Preprint
      Endogenous FGFs drive ERK-dependent cell fate patterning in 2D human gastruloids
      Jo K, Liu Z-Y, Patel G, Yu Z, Yao L, Teague S, Johnson C, Spence J, Heemskerk I. 2024 Nov 8; eLife Sciences Publications, Ltd, DOI:10.7554/elife.101224
    • Preprint
      Endogenous FGFs drive ERK-dependent cell fate patterning in 2D human gastruloids
      Jo K, Liu Z-Y, Patel G, Yu Z, Yao L, Teague S, Johnson C, Spence J, Heemskerk I. 2024 Nov 8; eLife Sciences Publications, Ltd, DOI:10.7554/elife.101224.1
    • Additional Scholarship
      Data from GRAIL1 Stabilizes Misfolded Mutant p53 through a Ubiquitin Ligase-Independent, Chaperone Regulatory Function
      Ray P, Jaiswal S, Ferrer-Torres D, Wang Z, Nancarrow D, Curtin M, Martinho MS, Lacy SM, Kasturirangan S, Thomas D, Spence JR, Truttmann MC, Lagisetty KH, Lawrence TS, Wang TD, Beer DG, Ray D. 2024 Nov 1; DOI:10.1158/1541-7786.c.7520410
    • Additional Scholarship
      Supplementary Figure S1 from GRAIL1 Stabilizes Misfolded Mutant p53 through a Ubiquitin Ligase-Independent, Chaperone Regulatory Function
      Ray P, Jaiswal S, Ferrer-Torres D, Wang Z, Nancarrow D, Curtin M, Martinho MS, Lacy SM, Kasturirangan S, Thomas D, Spence JR, Truttmann MC, Lagisetty KH, Lawrence TS, Wang TD, Beer DG, Ray D. 2024 Nov 1; DOI:10.1158/1541-7786.27435436
    • Additional Scholarship
      Supplementary Figure S2 from GRAIL1 Stabilizes Misfolded Mutant p53 through a Ubiquitin Ligase-Independent, Chaperone Regulatory Function
      Ray P, Jaiswal S, Ferrer-Torres D, Wang Z, Nancarrow D, Curtin M, Martinho MS, Lacy SM, Kasturirangan S, Thomas D, Spence JR, Truttmann MC, Lagisetty KH, Lawrence TS, Wang TD, Beer DG, Ray D. 2024 Nov 1; DOI:10.1158/1541-7786.27435433
    • Additional Scholarship
      Supplementary Figure S3 from GRAIL1 Stabilizes Misfolded Mutant p53 through a Ubiquitin Ligase-Independent, Chaperone Regulatory Function
      Ray P, Jaiswal S, Ferrer-Torres D, Wang Z, Nancarrow D, Curtin M, Martinho MS, Lacy SM, Kasturirangan S, Thomas D, Spence JR, Truttmann MC, Lagisetty KH, Lawrence TS, Wang TD, Beer DG, Ray D. 2024 Nov 1; DOI:10.1158/1541-7786.27435427
    • Additional Scholarship
      Supplementary Figure S4 from GRAIL1 Stabilizes Misfolded Mutant p53 through a Ubiquitin Ligase-Independent, Chaperone Regulatory Function
      Ray P, Jaiswal S, Ferrer-Torres D, Wang Z, Nancarrow D, Curtin M, Martinho MS, Lacy SM, Kasturirangan S, Thomas D, Spence JR, Truttmann MC, Lagisetty KH, Lawrence TS, Wang TD, Beer DG, Ray D. 2024 Nov 1; DOI:10.1158/1541-7786.27435424