Corentin Cras-Meneur
Associate Research Scientist
Internal Medicine
Internal Medicine (MEND Division)
2800 Plymouth Rd, B20-213W
Ann Arbor, MI 48109
[email protected]

Available to mentor
Corentin Cras-Meneur
Associate Research Scientist
  • About
  • Links
  • Qualifications
  • Center Memberships
  • Research Overview
  • Recent Publications
    • About

    Dr. Cras-Méneur studied pancreatic organogenesis for his Ph.D. under the supervision of Pr. Scharfmann in Hôpital Robert Debré (Paris, France). He received his Ph.D. in the “Molecular Genetics of Developmental Diseases and Oncogenesis” track at Université Paris 5 (René Descartes) in 2002.
    He then moved on for a postdoctoral fellowship on the functional genomics of the pancreas with Pr. M. Alan Permutt in Washington University School of Medicine in St. Louis, MO.
    In 2009, Dr. Cras-Méneur moved to the University of Michigan joining the faculty of Internal Medicine (Metabolism and Endocrinology Division).

    Links
    • Lab
    • Islet Core
    • linkedin
    • Researchgate
    • Google Scholar
    Qualifications
    • Postdoctoral fellowship
      Washington University in St. Louis School of Medicine, Internal Medicine (Division of Endocrinology, Metabolism & Lipid Research), 2009
    • Ph.D.
      Paris Descartes University, Paris, 2002
    Center Memberships
    • Center Member
      Caswell Diabetes Institute
    Research Overview

    Dr. Cras-Méneur’s work focuses on the events that regulate pancreatic β-cell differentiation and function. His work has been focused on three related axes:
    • Pancreatic development (mesenchyme-epithelium interactions, control of the fate of the endocrine cells).
    • Functional Genomics (bioinformatics analysis of the transcriptome of the endocrine pancreas under physiological and experimental conditions).
    • Insulin signaling (control of insulin biosynthesis, control of the proliferation and resistance to stress of the β-cells).

    Recent Publications See All Publications
    • Journal Article
      mTORC1 regulates high levels of protein synthesis in retinal ganglion cells of adult mice.
      Fort PE, Losiewicz MK, Elghazi L, Kong D, Cras-Méneur C, Fingar DC, Kimball SR, Rajala RVS, Smith AJ, Ali RR, Abcouwer SF, Gardner TW. J Biol Chem, 2022 Jun; 298 (6): 101944 DOI:10.1016/j.jbc.2022.101944
      PMID: 35447116
    • Journal Article
      mTORC1 regulates high levels of protein synthesis in retinal ganglion cells of adult mice.
      Fort PE, Losiewicz MK, Elghazi L, Kong D, Cras-Méneur C, Fingar DC, Kimball SR, Rajala RVS, Smith AJ, Ali RR, Abcouwer SF, Gardner TW. The Journal of biological chemistry, 2022 Jan 18; 298 (6):
    • Journal Article
      Beta-cell specific Insr deletion promotes insulin hypersecretion and improves glucose tolerance prior to global insulin resistance.
      Skovsø S, Panzhinskiy E, Kolic J, Cen HH, Dionne DA, Dai X-Q, Sharma RB, Elghazi L, Ellis CE, Faulkner K, Marcil SAM, Overby P, Noursadeghi N, Hutchinson D, Hu X, Li H, Modi H, Wildi JS, Botezelli JD, Noh HL, Suk S, Gablaski B, Bautista A, Kim R, Cras-Méneur C, Flibotte S, Sinha S, Luciani DS, Nislow C, Rideout EJ, Cytrynbaum EN, Kim JK, Bernal-Mizrachi E, Alonso LC, MacDonald PE, Johnson JD. Nat Commun, 2022 Feb 8; 13 (1): 735 DOI:10.1038/s41467-022-28039-8
      PMID: 35136059
    • Journal Article
      Improved in vivo imaging method for individual islets across the mouse pancreas reveals a heterogeneous insulin secretion response to glucose.
      Frikke-Schmidt H, Arvan P, Seeley RJ, Cras-Méneur C. Sci Rep, 2021 Jan 12; 11 (1): 603 DOI:10.1038/s41598-020-79727-8
      PMID: 33436691
    • Journal Article
      Improved in vivo imaging method for individual islets across the mouse pancreas reveals a heterogeneous insulin secretion response to glucose
      Frikke-Schmidt H, Arvan P, Seeley RJ, Cras-Méneur C. Nature Scientific Reports, 2021 Jan 1; Jan 12;11 (1):
    • Proceeding / Abstract / Poster
      215-OR: Silencing CCKBR Containing Neurons in the VMN Restrains Hepatic Glucose Production to Ameliorate Diabetes in Mice
      AFFINATI A, FLAK J, BOZADJIEVA N, KODUR N, CRAS-MÉNEUR CM, SANDOVAL DA, MYERS MG. Diabetes, 2020 Jun 1; 69 (Supplement_1): DOI:10.2337/db20-215-or
    • Journal Article
      Ventromedial hypothalamic nucleus neuronal subset regulates blood glucose independently of insulin.
      Flak JN, Goforth PB, Dell'Orco J, Sabatini PV, Li C, Bozadjieva N, Sorensen M, Valenta A, Rupp A, Affinati AH, Cras-Méneur C, Ansari A, Sacksner J, Kodur N, Sandoval DA, Kennedy RT, Olson DP, Myers MG. J Clin Invest, 2020 Jun 1; 130 (6): 2943 - 2952. DOI:10.1172/JCI134135
      PMID: 32134398
    • Journal Article
      In vivo imaging of individual islets across the mouse pancreas reveals a heterogeneous insulin secretion response to glucose
      Frikke-Schmidt H, Arvan P, Seeley RJ, Cras-Méneur C. BioRxiv, 2020 May 1; 2020: