Daniel R Goldstein, MD
Eliza Maria Mosher Collegiate Professor of Internal Medicine
Professor of Internal Medicine
Professor of Microbiology and Immunology
Research Professor
Institute of Gerontology
[email protected]

Available to mentor

Daniel R Goldstein, MD
  • About
  • Links
  • Qualifications
  • Center Memberships
  • Research Overview
  • Recent Publications
  • About

    Daniel R. Goldstein obtained his medical degree from St. George’s, University of London, UK. He undertook a medical residency at Johns Hopkins Bayview Medical Center in Baltimore, MD, USA and his cardiovascular disease, heart failure and transplantation training at the University of Alabama, Birmingham (UAB). At UAB he was postdoctoral fellow studying transplantation immunology. Until April 2016, his entire faculty career has been at the Yale School of Medicine, New Haven CT, USA.

    On April 1, 2016, he moved to the University of Michigan to direct a basic science center on cardiovascular aging (Michigan Biology of Cardiovascular Aging, MBOCA). His research interests include how inflammation impacts organ transplantation and how aging impacts acute and chronic inflammation. He is a member of the American Society of Clinical Investigation, an Established Investigator of the American Heart Association, a Paul Beeson Scholar in Aging Research, a recipient of an Academic Leadership Award from the National Institute on Aging, National Institute of Health, and a recipient of an Outstanding Investigator R35 award from the National Heart, Lung, and Blood Institute. In January 2021, he became the Editor-in-Chief of The Journal of Heart and Lung Transplantation www.JHLTonline.org, the journal of the www.ishlt.org.

    • MB BS
      St. George's, Univ of London, Cranmer Terrace, 1992
    Center Memberships
    • Center Member
      Taubman Institute
    • Center Member
      Caswell Diabetes Institute
    • Center Member
      Samuel and Jean Frankel Cardiovascular Center
    Research Overview

    Dr. Goldstein is interested in how aging impacts innate immunity. Currently, he works in two broad areas: aging and respiratory viral infections and aging and vascular diseases.

    Active research programs:

    • How aging impacts inflammation resolution during lung inflammation
    • How aging impacts mitochondrial quality control to impact acute and chronic inflammation
    • Role of senescence in acute viral infections
    • How aging impacts the vasculature to increase transplant vasculopathy
    • Mechanisms by which aging impacts atherosclerosis and aortic aneurysms

    Recent Publications See All Publications
    • Journal Article
      Itaconate suppresses atherosclerosis by activating a Nrf2-dependent antiinflammatory response in macrophages in mice.
      Song J, Zhang Y, Frieler RA, Andren A, Wood S, Tyrrell DJ, Sajjakulnukit P, Deng JC, Lyssiotis CA, Mortensen RM, Salmon M, Goldstein DR. J Clin Invest, 2023 Dec 12; 134 (3): DOI:10.1172/JCI173034
      PMID: 38085578
    • Journal Article
      Clonally expanded memory CD8+ T cells accumulate in atherosclerotic plaques and are pro-atherogenic in aged mice.
      Tyrrell DJ, Wragg KM, Chen J, Wang H, Song J, Blin MG, Bolding C, Vardaman D, Giles K, Tidwell H, Ali MA, Janappareddi A, Wood SC, Goldstein DR. Nat Aging, 2023 Dec; 3 (12): 1576 - 1590. DOI:10.1038/s43587-023-00515-w
      PMID: 37996758
    • Journal Article
      My time to say goodbye to JHLT.
      Goldstein DR. J Heart Lung Transplant, 2023 Oct; 42 (10): 1319 - 1320. DOI:10.1016/j.healun.2023.06.008
      PMID: 37410000
    • Journal Article
      Immune mechanisms of cardiac aging.
      Goldstein DR, Abdel-Latif A. J Cardiovasc Aging, 2023 3 (2): DOI:10.20517/jca.2023.02
      PMID: 37092016
    • Journal Article
      Age-associated adipose tissue inflammation promotes monocyte chemotaxis and enhances atherosclerosis.
      Song J, Farris D, Ariza P, Moorjani S, Varghese M, Blin M, Chen J, Tyrrell D, Zhang M, Singer K, Salmon M, Goldstein DR. Aging Cell, 2023 Feb; 22 (2): e13783 DOI:10.1111/acel.13783
      PMID: 36683460
    • Journal Article
      Neutrophils drive pulmonary vascular leakage in MHV-1 infection of susceptible A/J mice.
      Gong HH, Worley MJ, Carver KA, Goldstein DR, Deng JC. Front Immunol, 2022 13: 1089064 DOI:10.3389/fimmu.2022.1089064
      PMID: 36685578
    • Journal Article
      Increased soluble urokinase plasminogen activator levels modulate monocyte function to promote atherosclerosis.
      Hindy G, Tyrrell DJ, Vasbinder A, Wei C, Presswalla F, Wang H, Blakely P, Ozel AB, Graham S, Holton GH, Dowsett J, Fahed AC, Amadi K-M, Erne GK, Tekmulla A, Ismail A, Launius C, Sotoodehnia N, Pankow JS, Thørner LW, Erikstrup C, Pedersen OB, Banasik K, Brunak S, Ullum H, Eugen-Olsen J, Ostrowski SR, DBDS Consortium , Haas ME, Nielsen JB, Lotta LA, Regeneron Genetics Center , Engström G, Melander O, Orho-Melander M, Zhao L, Murthy VL, Pinsky DJ, Willer CJ, Heckbert SR, Reiser J, Goldstein DR, Desch KC, Hayek SS. J Clin Invest, 2022 Dec 15; 132 (24): DOI:10.1172/JCI158788
      PMID: 36194491
    • Journal Article
      Age-induced prostaglandin E2 impairs mitochondrial fitness and increases mortality to influenza infection.
      Chen J, Deng JC, Zemans RL, Bahmed K, Kosmider B, Zhang M, Peters-Golden M, Goldstein DR. Nat Commun, 2022 Nov 9; 13 (1): 6759 DOI:10.1038/s41467-022-34593-y
      PMID: 36351902