Henry L Paulson
Lucile Groff Chair of Neurology for Alzheimers Disease
Research Professor
Michigan Neuroscience Institute
Professor of Neurology and Co-Division Chief Cognitive Disorders
Medical School
[email protected]

Available to mentor
Henry L Paulson
Professor
  • About
  • Qualifications
  • Center Memberships
  • Research Overview
  • Recent Publications
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    About

    Dr. Paulson is the Lucile Groff Professor of Neurology in the Department of Neurology at the University of Michigan, where he also serves as Director of the Michigan Alzheimer’s Disease Center. Dr. Paulson received his MD and PhD degrees from Yale University, completed residency and fellowship training at the University of Pennsylvania, and previously taught at the University of Iowa. His research and clinical interests concern the causes and treatment of age-related neurodegenerative diseases, with an emphasis on repeat expansion diseases and age-related dementias. He is a member of the National Academy of Medicine, an elected fellow of the American Association for the Advancement of Science, and a recipient of the Landis Outstanding Mentor Award from the National Institutes of Health.

    Qualifications
    • movement disorders and neurogenetics
      University of Pennsylvania Health System, Philadelphia, 1997
    Center Memberships
    • Center Member
      Taubman Institute
    Research Overview

    Dr. Paulson's basic and clinical research focuses on age-related neurodegenerative diseases including Alzheimer's and related dementias as well as hereditary movement disorders including the ataxias. He directs the Michigan Alzheimer's Disease Center, which supports a wide range research projects to understand the causes and treatment of cognitive impairment. His laboratory studies the molecular mechanisms of various neurodegenerative diseases, with the goal of identifying therapeutic targets that can lead to treatments for currently fatal disorders.

    Recent Publications See All Publications
    • Journal Article
      WMH Contributions to Cognitive Impairment: Rationale and Design of the Diverse VCID Study
      DeCarli C, Rajan KB, Jin LW, Hinman J, Johnson DK, Harvey D, Fornage M, Beiser A, Gonzalez H, Kukull W, Barnes L, Elahi F, Croff R, Kramer J, Weickenmeier J, Tudorascu D, Albert M, Craft S, Jicha G, Wolk DA, Paulson H, Brewer J, Asthana S, Seshadri S, Brickman A, Chui HC, Nelson A, Savitz S, Saykin A, Geldmacher D, Masurkar A, Rundek T, Maillard P, Knaack A. Stroke, 2025 Mar 1; 56 (3): 758 - 776. DOI:10.1161/STROKEAHA.124.045903
      PMID: 39545328
    • Journal Article
      Amyloid-β predominant Alzheimer's disease neuropathologic change.
      Kovacs GG, Katsumata Y, Wu X, Aung KZ, Fardo DW, Forrest SL, Alzheimer's Disease Genetics Consortium , Nelson PT. Brain, 2025 Feb 3; 148 (2): 401 - 407. DOI:10.1093/brain/awae325
      PMID: PMC11788189
    • Journal Article
      Neuropsychiatric symptoms cluster and fluctuate over time in behavioral variant frontotemporal dementia
      Morrow CB, Kamath V, Dickerson BC, Eldaief M, Rezaii N, Wong B, McGinnis S, Darby R, Staffaroni AM, Lapid MI, Pascual B, Rojas JC, Masdeu JC, Tsapkini K, Huey ED, Fisher DW, Pantelyat A, Balaji A, Sah E, Litvan I, Rascovsky K, Ghoshal N, Domoto-Reilly K, Kornak J, Onyike CU, Abdullah M, Apostolova L, Appleby B, Barmada S, Bayram E, Boeve B, Botha H, Boxer AL, Bozoki A, Brushaber D, Clark D, Considine CM, Darby RR, Day GS, Dickerson B, Dickson D, Domoto-Reilly K, Dwosh E, Faber K, Fagan A, Fields JA, Fong JC, Foroud T, Forsberg LK, Galasko DR, Gavrilova R, Gendron T, Geschwind D, Ghoshal N, Goldman J, Graff-Radford J, Graff-Radford N, Grant IM, Grossman M, Hales CM, Hall M, Heuer HW, Honig LS, Ging-Yuek H, Huang E, Huey ED, Irwin D, Johnson N, Jones DT, Kantarci K, Knopman D, Kolander T, Kornak J, Kremers W, Kwan J, Lago AL, Lapid M, Lavigne SB, Lee S, Léger GC, Litvan I, Ljubenkov P, Lucente D, Mackenzie IR, Masdeu JC, Massimo L, McGinnis S, McMillan CT, Mendez MF, Mester C, Miyagawa T, Molden J, Onyike C, Pantelyat A, Pascual B, Paulson H, Petrucelli L, Pressman P, Rademakers R, Ramanan V. Psychiatry and Clinical Neurosciences, 2025 Jan 1; DOI:10.1111/pcn.13810
      PMID: 40079430
    • Journal Article
      Spinocerebellar Ataxia Progression Measured with the Patient-Reported Outcome Measure of Ataxia
      Burt AL, L'Italien G, Perlman SL, Rosenthal LS, Kuo SH, Ashizawa T, Zesiewicz T, Dietiker C, Opal P, Duquette A, Wilmot GR, Shakkottai VG, Gomez CM, Srinivasan SR, Paulson H, Geschwind MD, Worley S, Onyike CU, Billnitzer A, Ferng A, Matulis K, Davis MY, Subramony SH, Gupta A, Stephen CD, Schmahmann JD. Movement Disorders, 2025 Jan 1; DOI:10.1002/mds.30158
    • Journal Article
      Alzheimer's Imaging Consortium.
      Best MN, Levy J, Spencer A, Min L, Olafasson E, Pinarbasi E, Sexton J, Jenkins PM, Carruthers VB, Paulson HL. Alzheimers Dement, 2024 Dec; 20 Suppl 9: e094106 DOI:10.1002/alz.094106
      PMID: 39782721
    • Journal Article
      Basic Science and Pathogenesis
      Best MN, Levy J, Spencer A, Min L, Olafasson E, Pinarbasi E, Sexton J, Jenkins PM, Carruthers VB, Paulson HL. Alzheimer's & dementia : the journal of the Alzheimer's Association, 2024 Dec 1; 20: e092937 DOI:10.1002/alz.092937
      PMID: 39750902
    • Journal Article
      Clinical, Radiological and Pathological Features of a Large American Cohort of Spinocerebellar Ataxia (SCA27B)
      Abou Chaar W, Eranki AN, Stevens HA, Watson SL, Wong DY, Avila VS, Delfeld M, Gary AJ, Tawde S, Triebold M, Cherchi M, Xie T, Lockhart PJ, Bahlo M, Pellerin D, Dicaire MJ, Danzi M, Zuchner S, Brais BC, Perlman S, Burmeister M, Paulson H, Srinivasan S, Schut L, Bower M, Bushara K, Liao C, Shakkottai VG, Collins J, Clark HB, Das S, Fogel BL, Gomez CM. Annals of Neurology, 2024 Dec 1; 96 (6): 1092 - 1103. DOI:10.1002/ana.27060
      PMID: 39263992
    • Journal Article
      Developing Topics.
      Gierzynski TF, Reader JM, Flores B, Gadwa R, Bhaumik AK, Rahman-Filipiak A, Heidebrink JL, Giordani B, Hampstead BM, Bakulski KM, Paulson HL, Roberts JS. Alzheimers Dement, 2024 Dec; 20 Suppl 8: e095026 DOI:10.1002/alz.095026
      PMID: 39783551
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