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Dr. Paulson is the Lucile Groff Professor of Neurology in the Department of Neurology at the University of Michigan, where he also serves as Director of the Michigan Alzheimer’s Disease Center. Dr. Paulson received his MD and PhD degrees from Yale University, completed residency and fellowship training at the University of Pennsylvania, and previously taught at the University of Iowa. His research and clinical interests concern the causes and treatment of age-related neurodegenerative diseases, with an emphasis on repeat expansion diseases and age-related dementias. He is a member of the National Academy of Medicine, an elected fellow of the American Association for the Advancement of Science, and a recipient of the Landis Outstanding Mentor Award from the National Institutes of Health.
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movement disorders and neurogeneticsUniversity of Pennsylvania Health System, Philadelphia, 1997
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Center MemberTaubman Institute
Dr. Paulson's basic and clinical research focuses on age-related neurodegenerative diseases including Alzheimer's and related dementias as well as hereditary movement disorders including the ataxias. He directs the Michigan Alzheimer's Disease Center, which supports a wide range research projects to understand the causes and treatment of cognitive impairment. His laboratory studies the molecular mechanisms of various neurodegenerative diseases, with the goal of identifying therapeutic targets that can lead to treatments for currently fatal disorders.
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Armstrong MJ, Dai Y, Sovich K, LaBarre B, Paulson HL, Maixner SM, Fields JA, Lunde AM, Forsberg LK, Boeve BF, Manning CA, Galvin JE, Taylor AS, Li Z. Neurol Clin Pract, 2024 Jun; 14 (3): e200292Journal ArticleCaregiver Experiences and Burden in Moderate-Advanced Dementia With Lewy Bodies.
DOI:10.1212/CPJ.0000000000200292 PMID: 38617555 -
Albertson R, Paulson H, Srinivasan S, Shakkottai V, Todd P. Neurology, 2024 Apr 9; 102 (17_supplement_1):Journal ArticleDiagnostic Yield of Genetic Testing Over Five Years in a Tertiary Ataxia Clinic (P7-3.017)
DOI:10.1212/wnl.0000000000205545 -
Armstrong MJ, LaBarre B, Sovich K, Maixner SM, Paulson HL, Manning C, Fields JA, Lunde A, Forsberg L, Boeve BF, Galvin JE, Taylor AS, Li Z. Alzheimers Dement, 2024 Apr; 20 (4): 2719 - 2730.Journal ArticlePatient- and proxy-reported quality of life in advanced dementia with Lewy bodies.
DOI:10.1002/alz.13745 PMID: 38400528 -
Xicota L, Cosentino S, Vardarajan B, Mayeux R, Perls TT, Andersen SL, Zmuda JM, Thyagarajan B, Yashin A, Wojczynski MK, Krinsky-McHale S, Handen BL, Christian BT, Head E, Mapstone ME, Schupf N, Lee JH, Barral S, Long‐Life Family Study (LLFS) , Alzheimer's Disease Genetic Consortium (ADGC) , Alzheimer's Biomarkers Consortium‐Down Syndrome (ABC‐DS) . Alzheimers Dement, 2024 Apr; 20 (4): 2670 - 2679.Journal ArticleWhole genome-wide sequence analysis of long-lived families (Long-Life Family Study) identifies MTUS2 gene associated with late-onset Alzheimer's disease.
DOI:10.1002/alz.13718 PMID: 38380866 -
Safren N, Dao TP, Mohan HM, Huang C, Trotter B, Castañeda CA, Paulson H, Barmada S, Sharkey LM. Sci Rep, 2024 Mar 13; 14 (1): 6049Journal ArticlePathogenic mutations in UBQLN2 exhibit diverse aggregation propensity and neurotoxicity.
DOI:10.1038/s41598-024-55582-9 PMID: 38472280 -
Wang X, Bakulski KM, Karvonen-Gutierrez CA, Park SK, Morgan D, Albin RL, Paulson HL. Alzheimers Dement, 2024 Mar; 20 (3): 1807 - 1814.Journal ArticleBlood-based biomarkers for Alzheimer's disease and cognitive function from mid- to late life.
DOI:10.1002/alz.13583 PMID: 38126555 -
Gierzynski TF, Gregoire A, Reader JM, Pantis R, Campbell S, Bhaumik A, Rahman-Filipiak A, Heidebrink J, Giordani B, Paulson H, Hampstead BM. J Int Neuropsychol Soc, 2024 Feb; 30 (2): 183 - 193.Journal ArticleEvaluation of the Uniform Data Set version 3 teleneuropsychological measures.
DOI:10.1017/S1355617723000383 PMID: 37366070 -
Heidebrink JL, Paulson HL. Annu Rev Med, 2024 Jan 29; 75: 99 - 111.Journal ArticleLessons Learned from Approval of Aducanumab for Alzheimer's Disease.
DOI:10.1146/annurev-med-051022-043645 PMID: 38285515
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