Henry L Paulson
Lucile Groff Chair of Neurology for Alzheimers Disease
Research Professor
Michigan Neuroscience Institute
Professor of Neurology and Co-Division Chief Cognitive Disorders
[email protected]

Available to mentor

Henry L Paulson
Professor
  • About
  • Qualifications
  • Center Memberships
  • Research Overview
  • Recent Publications
  • About

    Dr. Paulson is the Lucile Groff Professor of Neurology in the Department of Neurology at the University of Michigan, where he also serves as Director of the Michigan Alzheimer’s Disease Center. Dr. Paulson received his MD and PhD degrees from Yale University, completed residency and fellowship training at the University of Pennsylvania, and previously taught at the University of Iowa. His research and clinical interests concern the causes and treatment of age-related neurodegenerative diseases, with an emphasis on repeat expansion diseases and age-related dementias. He is a member of the National Academy of Medicine, an elected fellow of the American Association for the Advancement of Science, and a recipient of the Landis Outstanding Mentor Award from the National Institutes of Health.

    Qualifications
    • movement disorders and neurogenetics
      University of Pennsylvania Health System, Philadelphia, 1997
    Center Memberships
    • Center Member
      Taubman Institute
    Research Overview

    Dr. Paulson's basic and clinical research focuses on age-related neurodegenerative diseases including Alzheimer's and related dementias as well as hereditary movement disorders including the ataxias. He directs the Michigan Alzheimer's Disease Center, which supports a wide range research projects to understand the causes and treatment of cognitive impairment. His laboratory studies the molecular mechanisms of various neurodegenerative diseases, with the goal of identifying therapeutic targets that can lead to treatments for currently fatal disorders.

    Recent Publications See All Publications
    • Journal Article
      Endogenous retrovirus-like proteins recruit UBQLN2 to stress granules and alter their functional properties.
      Mohan HM, Fernandez MG, Huang C, Lin R, Ryou JH, Seyfried D, Grotewold N, Whiteley AM, Barmada SJ, Basrur V, Mosalaganti S, Paulson HL, Sharkey LM. bioRxiv, 2024 Oct 25; DOI:10.1101/2024.10.24.620053
      PMID: 39484508
    • Journal Article
      Sensitivity of Advanced Magnetic Resonance Imaging to Progression over Six Months in Early Spinocerebellar Ataxia.
      Rezende TJR, Petit E, Park YW, Tezenas du Montcel S, Joers JM, DuBois JM, Moore Arnold H, Povazan M, Banan G, Valabregue R, Ehses P, Faber J, Coupé P, Onyike CU, Barker PB, Schmahmann JD, Ratai E-M, Subramony SH, Mareci TH, Bushara KO, Paulson H, Klockgether T, Durr A, Ashizawa T, Lenglet C, Öz G, READISCA Consortium . Mov Disord, 2024 Oct; 39 (10): 1856 - 1867. DOI:10.1002/mds.29934
      PMID: 39056163
    • Journal Article
      Lead Exposure and Incidence of Alzheimer's Disease and Related Dementias in the United States
      Wang X, Bakulski KM, Walker E, Mukherjee B, Dodge H, Albin RL, Paulson HL, Park SK. ISEE Conference Abstracts, 2024 Aug 15; 2024 (1): DOI:10.1289/isee.2024.1931
    • Journal Article
      End-of-life experiences in individuals with dementia with Lewy bodies and their caregivers: A mixed-methods analysis.
      Wollney E, Sovich K, LaBarre B, Maixner SM, Paulson HL, Manning C, Fields JA, Lunde A, Boeve BF, Galvin JE, Taylor AS, Li Z, Fechtel HJ, Armstrong MJ. PLoS One, 2024 19 (8): e0309530 DOI:10.1371/journal.pone.0309530
      PMID: 39208192
    • Journal Article
      The Cerebellar Cognitive Affective/Schmahmann Syndrome Scale in Spinocerebellar Ataxias.
      Selvadurai LP, Perlman SL, Ashizawa T, Wilmot GR, Onyike CU, Rosenthal LS, Shakkottai VG, Paulson HL, Subramony SH, Bushara KO, Kuo S-H, Dietiker C, Geschwind MD, Nelson AB, Gomez CM, Opal P, Zesiewicz TA, Hawkins T, Yacoubian TA, Nopoulos PC, Sha SJ, Morrison PE, Figueroa KP, Pulst SM, Schmahmann JD. Cerebellum, 2024 Aug; 23 (4): 1411 - 1425. DOI:10.1007/s12311-023-01651-0
      PMID: 38165578
    • Journal Article
      SARA captures disparate progression and responsiveness in spinocerebellar ataxias.
      Petit E, Schmitz-Hübsch T, Coarelli G, Jacobi H, Heinzmann A, Figueroa KP, Perlman SL, Gomez CM, Wilmot GR, Schmahmann JD, Ying SH, Zesiewicz TA, Paulson HL, Shakkottai VG, Bushara KO, Kuo S-H, Geschwind MD, Xia G, Pulst SM, Subramony SH, Ewenczyk C, Brice A, Durr A, Klockgether T, Ashizawa T, Tezenas du Montcel S. J Neurol, 2024 Jul; 271 (7): 3743 - 3753. DOI:10.1007/s00415-024-12475-1
      PMID: 38822840
    • Journal Article
      SCAview: an Intuitive Visual Approach to the Integrative Analysis of Clinical Data in Spinocerebellar Ataxias.
      Uebachs M, Wegner P, Schaaf S, Kugai S, Jacobi H, Kuo S-H, Ashizawa T, Fluck J, EUROSCA study group , ESMI study group , RISCA study group , CRC-SCA study group , SCA Registry study group , Klockgether T, Faber J. Cerebellum, 2024 Jun; 23 (3): 887 - 895. DOI:10.1007/s12311-023-01546-0
      PMID: 37002505
    • Journal Article
      Fatigue Impacts Quality of Life in People with Spinocerebellar Ataxias.
      Lai R-Y, Rummey C, Amlang CJ, Lin C-YR, Chen TX, Perlman S, Wilmot G, Gomez CM, Schmahmann JD, Paulson H, Ying SH, Onyike CU, Zesiewicz TA, Bushara KO, Geschwind MD, Figueroa KP, Pulst SM, Subramony SH, Burns MR, Opal P, Duquette A, Ashizawa T, Hamedani AG, Davis MY, Srinivasan SR, Moore LR, Shakkottai VG, Rosenthal LS, Kuo S-H. Mov Disord Clin Pract, 2024 May; 11 (5): 496 - 503. DOI:10.1002/mdc3.14006
      PMID: 38419568
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