Henry L Paulson
Lucile Groff Chair of Neurology for Alzheimers Disease
Research Professor
Michigan Neuroscience Institute
Professor of Neurology
Co-Division Chief Cognitive Disorders
[email protected]

Available to mentor

Henry L Paulson
  • About
  • Qualifications
  • Center Memberships
  • Research Overview
  • Recent Publications
  • About

    Dr. Paulson is the Lucile Groff Professor of Neurology in the Department of Neurology at the University of Michigan, where he also serves as Director of the Michigan Alzheimer’s Disease Center. Dr. Paulson received his MD and PhD degrees from Yale University, completed residency and fellowship training at the University of Pennsylvania, and previously taught at the University of Iowa. His research and clinical interests concern the causes and treatment of age-related neurodegenerative diseases, with an emphasis on repeat expansion diseases and age-related dementias. He is a member of the National Academy of Medicine, an elected fellow of the American Association for the Advancement of Science, and a recipient of the Landis Outstanding Mentor Award from the National Institutes of Health.

    • movement disorders and neurogenetics
      University of Pennsylvania Health System, Philadelphia, 1997
    Center Memberships
    • Center Member
      Taubman Institute
    Research Overview

    Dr. Paulson's basic and clinical research focuses on age-related neurodegenerative diseases including Alzheimer's and related dementias as well as hereditary movement disorders including the ataxias. He directs the Michigan Alzheimer's Disease Center, which supports a wide range research projects to understand the causes and treatment of cognitive impairment. His laboratory studies the molecular mechanisms of various neurodegenerative diseases, with the goal of identifying therapeutic targets that can lead to treatments for currently fatal disorders.

    Recent Publications See All Publications
    • Journal Article
      Caregiver Experiences and Burden in Moderate-Advanced Dementia With Lewy Bodies.
      Armstrong MJ, Dai Y, Sovich K, LaBarre B, Paulson HL, Maixner SM, Fields JA, Lunde AM, Forsberg LK, Boeve BF, Manning CA, Galvin JE, Taylor AS, Li Z. Neurol Clin Pract, 2024 Jun; 14 (3): e200292 DOI:10.1212/CPJ.0000000000200292
      PMID: 38617555
    • Journal Article
      Diagnostic Yield of Genetic Testing Over Five Years in a Tertiary Ataxia Clinic (P7-3.017)
      Albertson R, Paulson H, Srinivasan S, Shakkottai V, Todd P. Neurology, 2024 Apr 9; 102 (17_supplement_1): DOI:10.1212/wnl.0000000000205545
    • Journal Article
      Patient- and proxy-reported quality of life in advanced dementia with Lewy bodies.
      Armstrong MJ, LaBarre B, Sovich K, Maixner SM, Paulson HL, Manning C, Fields JA, Lunde A, Forsberg L, Boeve BF, Galvin JE, Taylor AS, Li Z. Alzheimers Dement, 2024 Apr; 20 (4): 2719 - 2730. DOI:10.1002/alz.13745
      PMID: 38400528
    • Journal Article
      Whole genome-wide sequence analysis of long-lived families (Long-Life Family Study) identifies MTUS2 gene associated with late-onset Alzheimer's disease.
      Xicota L, Cosentino S, Vardarajan B, Mayeux R, Perls TT, Andersen SL, Zmuda JM, Thyagarajan B, Yashin A, Wojczynski MK, Krinsky-McHale S, Handen BL, Christian BT, Head E, Mapstone ME, Schupf N, Lee JH, Barral S, Long‐Life Family Study (LLFS) , Alzheimer's Disease Genetic Consortium (ADGC) , Alzheimer's Biomarkers Consortium‐Down Syndrome (ABC‐DS) . Alzheimers Dement, 2024 Apr; 20 (4): 2670 - 2679. DOI:10.1002/alz.13718
      PMID: 38380866
    • Journal Article
      Pathogenic mutations in UBQLN2 exhibit diverse aggregation propensity and neurotoxicity.
      Safren N, Dao TP, Mohan HM, Huang C, Trotter B, Castañeda CA, Paulson H, Barmada S, Sharkey LM. Sci Rep, 2024 Mar 13; 14 (1): 6049 DOI:10.1038/s41598-024-55582-9
      PMID: 38472280
    • Journal Article
      Blood-based biomarkers for Alzheimer's disease and cognitive function from mid- to late life.
      Wang X, Bakulski KM, Karvonen-Gutierrez CA, Park SK, Morgan D, Albin RL, Paulson HL. Alzheimers Dement, 2024 Mar; 20 (3): 1807 - 1814. DOI:10.1002/alz.13583
      PMID: 38126555
    • Journal Article
      Evaluation of the Uniform Data Set version 3 teleneuropsychological measures.
      Gierzynski TF, Gregoire A, Reader JM, Pantis R, Campbell S, Bhaumik A, Rahman-Filipiak A, Heidebrink J, Giordani B, Paulson H, Hampstead BM. J Int Neuropsychol Soc, 2024 Feb; 30 (2): 183 - 193. DOI:10.1017/S1355617723000383
      PMID: 37366070
    • Journal Article
      Lessons Learned from Approval of Aducanumab for Alzheimer's Disease.
      Heidebrink JL, Paulson HL. Annu Rev Med, 2024 Jan 29; 75: 99 - 111. DOI:10.1146/annurev-med-051022-043645
      PMID: 38285515
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