Henry L Paulson
Lucile Groff Chair of Neurology for Alzheimers Disease
Interim Co-Director, Michigan Neuroscience Institute
Research Professor, Michigan Neuroscience Institute
Professor of Neurology and Co-Division Chief Cognitive Disorders
[email protected]

Available to mentor

Henry L Paulson
  • About
  • Center Memberships
  • Research Overview
  • Recent Publications
  • About

    Dr. Paulson is the Lucile Groff Professor of Neurology in the Department of Neurology at the University of Michigan, where he also serves as Director of the Michigan Alzheimer’s Disease Center. Dr. Paulson received his MD and PhD degrees from Yale University, completed residency and fellowship training at the University of Pennsylvania, and previously taught at the University of Iowa. His research and clinical interests concern the causes and treatment of age-related neurodegenerative diseases, with an emphasis on repeat expansion diseases and age-related dementias. He is a member of the National Academy of Medicine, an elected fellow of the American Association for the Advancement of Science, and a recipient of the Landis Outstanding Mentor Award from the National Institutes of Health.

    Center Memberships
    • Center Member
      Taubman Institute
    Research Overview

    Dr. Paulson's basic and clinical research focuses on age-related neurodegenerative diseases including Alzheimer's and related dementias as well as hereditary movement disorders including the ataxias. He directs the Michigan Alzheimer's Disease Center, which supports a wide range research projects to understand the causes and treatment of cognitive impairment. His laboratory studies the molecular mechanisms of various neurodegenerative diseases, with the goal of identifying therapeutic targets that can lead to treatments for currently fatal disorders.

    Recent Publications See All Publications
    • Journal Article
      Lessons Learned from Approval of Aducanumab for Alzheimer's Disease.
      Heidebrink JL, Paulson HL. Annu Rev Med, 2024 Jan 29; 75: 99 - 111. DOI:10.1146/annurev-med-051022-043645
      PMID: 38285515
    • Journal Article
      The Cerebellar Cognitive Affective/Schmahmann Syndrome Scale in Spinocerebellar Ataxias.
      Selvadurai LP, Perlman SL, Ashizawa T, Wilmot GR, Onyike CU, Rosenthal LS, Shakkottai VG, Paulson HL, Subramony SH, Bushara KO, Kuo S-H, Dietiker C, Geschwind MD, Nelson AB, Gomez CM, Opal P, Zesiewicz TA, Hawkins T, Yacoubian TA, Nopoulos PC, Sha SJ, Morrison PE, Figueroa KP, Pulst SM, Schmahmann JD. Cerebellum, 2024 Jan 2; DOI:10.1007/s12311-023-01651-0
      PMID: 38165578
    • Journal Article
      Upregulation of the ESCRT pathway and multivesicular bodies accelerates degradation of proteins associated with neurodegeneration.
      Benyair R, Giridharan SSP, Rivero-Ríos P, Hasegawa J, Bristow E, Eskelinen E-L, Shmueli MD, Fishbain-Yoskovitz V, Merbl Y, Sharkey LM, Paulson HL, Hanson PI, Patnaik S, Al-Ramahi I, Botas J, Marugan J, Weisman LS. Autophagy Rep, 2023 2 (1): DOI:10.1080/27694127.2023.2166722
      PMID: 37064812
    • Journal Article
      Associations of healthy lifestyle and socioeconomic status with cognitive function in U.S. older adults.
      Wang X, Bakulski KM, Paulson HL, Albin RL, Park SK. Sci Rep, 2023 May 9; 13 (1): 7513 DOI:10.1038/s41598-023-34648-0
      PMID: 37160962
    • Journal Article
      In vivo cortical diffusion imaging relates to Alzheimer's disease neuropathology.
      Torso M, Ridgway GR, Valotti M, Hardingham I, Chance SA, National Alzheimer’s Coordinating Center , Alzheimer’s Disease Neuroimaging Initiative . Alzheimers Res Ther, 2023 Oct 4; 15 (1): 165 DOI:10.1186/s13195-023-01309-3
      PMID: 37794477
    • Journal Article
      Ubiquilin-2 regulates pathological alpha-synuclein.
      Sandoval-Pistorius SS, Gerson JE, Liggans N, Ryou JH, Oak K, Li X, Negron-Rios KY, Fischer S, Barsh H, Crowley EV, Skinner ME, Sharkey LM, Barmada SJ, Paulson HL. Sci Rep, 2023 Jan 6; 13 (1): 293 DOI:10.1038/s41598-022-26899-0
      PMID: 36609661
    • Proceeding / Abstract / Poster
      19 Accuracy of Self- and Informant-Reported Domain-Specific Cognitive Ratings
      Kohl HS, Gregoire A, Reader J, Bhaumik A, Giordani B, Paulson H, Hampstead B, Rahman-Filipiak A. Journal of the International Neuropsychological Society, 2023 Nov; 29 (s1): 702 - 703. DOI:10.1017/s1355617723008779
    • Proceeding / Abstract / Poster
      97 Evaluation of Video and Telephone-Based Administration of the Uniform Data Set Version 3 (UDS v3.0) Teleneuropsychological Measures
      Gierzynski TF, Gregoire A, Reader JM, Pantis R, Campbell S, Bhaumik A, Rahman-Filipiak A, Heidebrink J, Giordani B, Paulson H, Hampstead BM. Journal of the International Neuropsychological Society, 2023 Nov; 29 (s1): 499 - 500. DOI:10.1017/s1355617723006458
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