
Available to mentor

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Ph.D.Yale University
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B.Sc.University of Waterloo
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Center MemberCenter for Cell Plasticity and Organ Design
Research in the Kwan laboratory is aimed at the genetic mechanisms that underlie neural development and circuit assembly in the cerebral cortex, and their dysregulation in human neurodevelopmental disorders, in particular autism spectrum disorder (ASD), intellectual disability, and schizophrenia. We specialize in unraveling the mechanistic underpinnings of fundamental and pathogenic developmental processes in vivo. Our three overarching goals are to understand: 1) the mechanisms by which neural progenitor cells (NPCs) give rise to diverse cortical cell types; 2) the mechanisms by which cortical neurons are wired into functional neural circuits; and 3) how dysregulation of these mechanisms contribute to disorders of brain development. We use an integrative approach at the interface of molecular biology, functional genomics, genome-editing, mouse genetics, and circuit neurobiology. With the accelerating pace of genetic discoveries, we are ideally positioned to functionally characterize genes associated with brain disorders, and uncover the mechanisms by which gene mutations contribute to disease in vivo.
Kwan Laboratory twitter Google Scholar
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Liao C, O'Farrell E, Qalieh Y, Savalia NK, Girgenti MJ, Kwan KY, Kwan AC. bioRxiv, 2025 Jan 4;Journal ArticleSingle-nucleus transcriptomics reveals time-dependent and cell-type-specific effects of psilocybin on gene expression.
DOI:10.1101/2025.01.04.631335 PMID: PMC11722411 -
Sun C, Kathuria K, Emery SB, Kim BJ, Burbulis IE, Shin JH, Gleeson JG, Breuss MW, Yang X, Antaki D, Chung C, Averbuj D, Ball LL, Roy S, Weinberger D, Jaffe A, Paquola A, Erwin J, Straub R, Narurkar R, Mathern G, Walsh CA, Lee A, Huang AY, D’Gama A, Dias C, Maury E, Ganz J, Lodato M, Miller M, Li P, Rodin R, Borges-Monroy R, Hill R, Bizzotto S, Khoshkhoo S, Kim S, Zhou Z, Park PJ, Barton A, Galor A, Chu C, Bohrson C, Gulhan D, Lim E, Lim E, Melloni G, Cortes I, Lee J, Luquette J, Yang L, Sherman M, Coulter M, Kwon M, Lee S, Lee S, Viswanadham V, Dou Y, Chess AJ, Jones A, Rosenbluh C, Akbarian S, Langmead B, Thorpe J, Cho S, Abyzov A, Bae T, Jang Y, Wang Y, Molitor C, Peters M, Gage FH, Wang M, Reed P, Linker S, Urban A, Zhou B, Pattni R, Zhu X, Amero AS, Juan D, Povolotskaya I, Lobon I, Moruno MS, Perez RG, Marques-Bonet T, Soriano E, Moran JV, Flasch DA, Frisbie TJ, Kopera HC, Moldovan JB, Kwan KY, Mills RE, Zhou W, Zhao X, Ratan A, Vaccarino FM, Cherskov A, Jourdon A, McConnell M. Nature Communications, 2025 Mar 3; 15 (1):Journal ArticleMapping recurrent mosaic copy number variation in human neurons
DOI:10.1038/s41467-024-48392-0 -
Sunyaev SR, Bizzotto S, Coulter M, Dias C, D'Gama A, Ganz J, Hill R, Huang AY, Khoshkhoo S, Kim S, Lee A, Lodato M, Maury E, Miller M, Borges-Monroy R, Rodin R, Walsh CA, Zhou Z, Bohrson C, Chu C, Cortes-Ciriano I, Dou Y, Galor A, Gulhan D, Kwon M, Luquette J, Park P, Sherman M, Viswanadham V, Akbarian S, Chess A, Jones A, Rosenbluh C, Cho S, Langmead B, Pevsner J, Thorpe J, Erwin J, Jaffe A, McConnell M, Narurkar R, Paquola A, Shin J, Straub R, Weinberger D, Abyzov A, Bae T, Jang Y, Molitor C, Peters M, Gage F, Linker S, Reed P, Wang M, Urban A, Zhou B, Zhu X, Pattni R, Serres Amero A, Juan D, Lobon I, Marques-Bonet T, Solis Moruno M, Garcia Perez R, Povolotskaya I, Soriano E, Mathern G, Antaki D, Averbuj D, Ball L, Breuss M, Courchesne E, Gleeson J, Yang X, Chung C, Emery SB, Flasch DA, Kidd JM, Kopera HC, Kwan KY, Mills RE, Moldovan JB, Moran JV, Sun C, Zhao X, Zhou W, Frisbie TJ, Wang Y, Cherskov A, Fasching L, Jourdon A, Pochareddy S, Scuderi S, Sestan N, Vaccarino F. Science, 2024 Oct 11; 386 (6718): 217 - 224.Journal ArticleSomatic mosaicism in schizophrenia brains reveals prenatal mutational processes
DOI:10.1126/science.adq1456 PMID: 39388546 -
Molnár Z, Kwan KY. Cold Spring Harbor Perspectives in Biology, 2024 Jan 1; 16 (1):Journal ArticleDevelopment and Evolution of Thalamocortical Connectivity
DOI:10.1101/cshperspect.a041503 PMID: 38167425 -
Garrison MKA, Jang Y, Bae T, Cherskov A, Emery SB, Fasching L, Jones A, Moldovan JB, Molitor C, Pochareddy S, Peters MA, Shin JH, Wang Y, Yang X, Akbarian S, Chess A, Gage FH, Gleeson JG, Kidd JM, McConnell M, Mills RE, Moran JV, Park PJ, Sestan N, Urban AE, Vaccarino FM, Walsh CA, Weinberger DR, Wheelan SJ, Abyzov A, Amero AS, Antaki D, Averbuj D, Ball L, Bizzotto S, Bohrson C, Borges-Monroy R, Breuss M, Cho S, Chu C, Chung C, Cortes-Ciriano I, Coulter M, Daily K, Dias C, D’Gama A, Dou Y, Erwin J, Flasch DA, Frisbie TJ, Galor A, Ganz J, Gulhan D, Hill R, Huang AY, Jaffe A, Jourdon A, Juan D, Khoshkhoo S, Kim S, Kopera HC, Kwan KY, Kwon M, Langmead B, Lee EA, Linker S, Lobon I, Lodato MA, Luquette LJ, Mathern G, Marques-Bonet T, Maury EA, Miller M, Moruno MS, Narurkar R, Paquola A, Pattni R, Perez RG, Povolotskaya I, Reed P, Rodin R, Rosenbluh C, Scuderi S, Sherman M, Straub R, Soriano E, Sun C, Thorpe J, Viswanadham V, Wang M, Zhao X, Zhou B, Zhou W, Zhou Z, Zhu X. Scientific Data, 2024 May 13; 10 (1):Journal ArticleGenomic data resources of the Brain Somatic Mosaicism Network for neuropsychiatric diseases
DOI:10.1038/s41597-023-02645-7 -
Zhu X, Zhou B, Pattni R, Gleason K, Tan C, Kalinowski A, Sloan S, Fiston-Lavier AS, Mariani J, Petrov D, Barres BA, Duncan L, Abyzov A, Vogel H, Zhu X, Urban A, Walsh C, Ganz J, Woodworth M, Li P, Rodin R, Hill R, Bizzotto S, Zhou Z, Lee A, D’Gama A, Galor A, Bohrson C, Kwon D, Gulhan D, Lim E, Cortes I, Luquette J, Sherman M, Coulter M, Lodato M, Park P, Monroy R, Kim S, Dou Y, Chess A, Jones A, Rosenbluh C, Akbarian S, Langmead B, Thorpe J, Pevsner J, Scharpf R, Cho S, Vaccarino F, Fasching L, Tomasi S, Sestan N, Pochareddy S, Jaffe A, Paquola A, Weinberger D, Erwin J, Shin J, Straub R, Narurkar R, Addington A, Panchision D, Meinecke D, Senthil G, Bingaman L, Dutka T, Lehner T, Abyzov A, Bae T, Saucedo-Cuevas L, Conniff T, Flasch DA, Frisbie TJ, Kidd JM, Lam MM, Moldovan JB, Moran JV, Kwan KY, Mills RE, Emery S, Zhou W, Wang Y, Daily K, Peters M, Gage F, Wang M, Reed P, Linker S, Sarkar A, Serres A, Juan D, Povolotskaya I, Lobon I, Solis M, Garcia R, Marques-Bonet T, Mathern G, Gu J. Nature Neuroscience, 2023 Oct 1; 26 (10): 1833Journal ArticleAuthor Correction: Machine learning reveals bilateral distribution of somatic L1 insertions in human neurons and glia (Nature Neuroscience, (2021), 24, 2, (186-196), 10.1038/s41593-020-00767-4)
DOI:10.1038/s41593-023-01438-w PMID: 37648813 -
Rodin RE, Dou Y, Kwon M, Sherman MA, D’Gama AM, Doan RN, Rento LM, Girskis KM, Bohrson CL, Kim SN, Nadig A, Luquette LJ, Gulhan DC, Walsh CA, Ganz J, Woodworth MB, Li P, Hill RS, Bizzotto S, Zhou Z, Lee EA, Barton AR, Galor A, Kwon D, Lim ET, Cortes IC, Luquette LJ, Sherman MA, Coulter ME, Lodato MA, Park PJ, Monroy RB, Kim SN, Dou Y, Chess A, Gulyás-Kovács A, Rosenbluh C, Akbarian S, Ben Langmead , Thorpe J, Pevsner J, Cho S, Jaffe AE, Paquola A, Weinberger DR, Erwin JA, Shin JH, Straub RE, Narurkar R, Abyzov AS, Bae T, Addington A, Panchision D, Meinecke D, Senthil G, Bingaman L, Dutka T, Lehner T, Saucedo-Cuevas L, Conniff T, Daily K, Peters M, Gage FH, Wang M, Reed PJ, Linker SB, Urban AE, Zhou B, Zhu X, Serres A, Juan D, Povolotskaya I, Lobón I, Solis-Moruno M, García-Pérez R, Marquès-Bonet T, Mathern GW, Gu J, Gleeson JG, Ball LL, George RD, Pramparo T, Flasch DA, Frisbie TJ, Kidd JM, Moldovan JB, Moran JV, Kwan KY, Mills RE, Emery SB, Zhou W, Wang Y, Ratan A, McConnell MJ, Vaccarino FM, Coppola G. Nature Neuroscience, 2024 May 10; 26 (10): 1833 - 1833.Journal ArticleAuthor Correction: The landscape of somatic mutation in cerebral cortex of autistic and neurotypical individuals revealed by ultra-deep whole-genome sequencing (Nature Neuroscience, (2021), 24, 2, (176-185), 10.1038/s41593-020-00765-6)
DOI:10.1038/s41593-023-01437-x -
Njoku IP, Kwan KY. Neuron, 2023 Apr 19; 111 (8): 1168 - 1170.Journal ArticleDistinct microtubule networks mediate neuronal migration and polarization
DOI:10.1016/j.neuron.2023.03.026 PMID: 37080166