Professor of Mechanical Engineering
Professor of Cell and Developmental Biology
[email protected]
Available to mentor
Jianping Fu, PhD
Professor
My group's research interests lie at the nexus of bioengineering, biophysics, and biology. Specifically, we integrate micro/nanoengineering, single-cell technologies, and systems and synthetic biology methods with new discoveries of mechanobiology, epigenetics, and stem cell biology for advancing understanding of human development and cancer biology. In our research, we have made significant contributions to these research areas: stem cell bioengineering, developmental bioengineering, cell mechanics, mechanotransduction, micro/nanofluidics, and BioMEMS.
Integrated Biosystems and Biomechanics Laboratory
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Center MemberCenter for Cell Plasticity and Organ Design
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Center MemberBiosciences Initiative
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Center MemberCenter for Integrative Research in Critical Care
Mechanobiology, Stem Cell Biology, Developmental Biology, Bioengineering, BioMEMS
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Esfahani SN, Zheng Y, Arabpour A, Irizarry AMR, Kobayashi N, Xue X, Shao Y, Zhao C, Agranonik NL, Sparrow M, Hunt TJ, Faith J, Lara MJ, Wu QY, Silber S, Petropoulos S, Yang R, Chien KR, Clark AT, Fu J. Nat Commun, 2024 Jan 2; 15 (1): 167Journal ArticleDerivation of human primordial germ cell-like cells in an embryonic-like culture.
DOI:10.1038/s41467-023-43871-2 PMID: 38167821 -
Lee HC, Oliveira NMM, Hastings C, Baillie-Benson P, Moverley AA, Lu H-C, Zheng Y, Wilby EL, Weil TT, Page KM, Fu J, Moris N, Stern CD. Nat Commun, 2024 Feb 17; 15 (1): 1463Journal ArticleRegulation of long-range BMP gradients and embryonic polarity by propagation of local calcium-firing activity.
DOI:10.1038/s41467-024-45772-4 PMID: 38368410 -
Xue X, Liu Y, Fu J. Nature Reviews Bioengineering, 1 - 19.Journal ArticleBioengineering embryo models
DOI:10.1038/s44222-024-00241-x -
Martinez Arias A, Rivron N, Moris N, Tam P, Alev C, Fu J, Hadjantonakis A-K, Hanna JH, Minchiotti G, Pourquie O, Sheng G, Solnica Krezel L, Veenvliet JV, Warmflash A. Nat Cell Biol, 2024 Oct; 26 (10): 1625 - 1628.Journal ArticleCriteria for the standardization of stem-cell-based embryo models.
DOI:10.1038/s41556-024-01492-x PMID: 39223372 -
Sun S, Zheng Y, Kim YS, Zhong Z, Kobayashi N, Xue X, Liu Y, Zhou Z, Xu Y, Zhai J, Wang H, Fu J. bioRxiv,PreprintA transgene-free, human peri-gastrulation embryo model with trilaminar embryonic disc-, amnion- and yolk sac-like structures
DOI:10.1101/2024.08.05.606556 -
Liu Y, Kim YS, Xue X, Miao Y, Kobayashi N, Sun S, Yan RZ, Yang Q, Pourquié O, Fu J. Cell Stem Cell, 2024 Aug 1; 31 (8): 1113 - 1126.e6.Journal ArticleA human pluripotent stem cell-based somitogenesis model using microfluidics.
DOI:10.1016/j.stem.2024.06.004 PMID: 38981471 -
Sung C-Y, Kadiyala U, Blanchard O, Yourston L, Walker D, Li L, Fu J, Yang Q. bioRxiv, 2024 Jul 4;Journal ArticleSubstrate Rigidity Modulates Segmentation Clock Dynamics in Isolated Presomitic Mesoderm Cells.
DOI:10.1101/2024.07.02.601712 PMID: 39005461 -
Holland EN, Fernández-Yagüe MA, Zhou DW, O'Neill EB, Woodfolk AU, Mora-Boza A, Fu J, Schlaepfer DD, García AJ. Biomaterials, 2024 Jul; 308: 122542Journal ArticleFAK, vinculin, and talin control mechanosensitive YAP nuclear localization.
DOI:10.1016/j.biomaterials.2024.122542 PMID: 38547833