Gabriel Corfas, PhD
Lynn and Ruth Townsend Professor of Communication Disorders
Kresge Hearing Research Institute Director
Otolaryngology-Head and Neck Surgery Associate Chair for Research
Professor of Otolaryngology-Head and Neck Surgery
Medical School
[email protected]

Available to mentor

Gabriel Corfas, PhD
Professor
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    About

    Gabriel Corfas obtained an MSc in Biological Sciences from the University of Buenos Aires and a doctorate in Neurobiology from the Weizmann Institute of Science. During his postdoctoral training, first at Washington University in St. Louis, MO, and then at Harvard Medical School, he contributed to identifying and cloning the trophic factor Neuregulin 1 and its mechanism of action. In 1996 he obtained a faculty position at Harvard Medical School and Boston Children’s Hospital (BCH), eventually becoming a Professor of Neurology and Otolaryngology and director of basic research in Otolaryngology at BCH.

    Since 2014 Corfas has been the Director of the Kresge Hearing Research Institute and associate chair for research for the Department of Otolaryngology and Head and Neck Surgery at the University of Michigan in Ann Arbor.

    Dr. Corfas’s research focuses on the cellular and molecular mechanisms of nervous system development, plasticity, degeneration, and regeneration. Current efforts are devoted to identifying the mechanisms of noise-induced and age-related hearing loss and developing therapies for these prevalent disorders. The lab also investigates how social isolation alters brain structure and function.

    For his work, Dr. Corfas has received many honors and awards, including a Klingenstein Fellowship in the Neurosciences, an Alfred P. Sloan Research Fellowship, an award from the EJLB Foundation, a Young and an Independent Investigator Award from NARSAD, as well as being elected secretary and treasurer of the Association for Research in Otolaryngology and a fellow of the American Association for the Advancement of Science.

    Center Memberships
    • Center Member
      Kresge Hearing Research Institute
    • Center Member
      Samuel and Jean Frankel Cardiovascular Center
    Research Overview

    Molecular and cellular mechanisms of brain development and plasticity
    Cellular and molecular mechanisms of inner ear development and function
    Hearing loss and Balance disorders
    Neuron-glia interactions
    Mechanisms of peripheral neuropathies
    Development of drugs for peripheral neuropathies

    Recent Publications See All Publications
    • Preprint
      Lipidomics profiling identifies β-oxidation as a key process in noise-induced hearing loss.
      Wallace G, Ji L, Cassinotti LR, Kachman M, Lyssiotis CA, Burant CF, Corfas G. 2025 Mar 26; DOI:10.1101/2025.03.25.645361
      PMID: 40196644
    • Journal Article
      A modiolar-pillar gradient in auditory-nerve dendritic length: A novel post-synaptic contribution to dynamic range?
      Kostrikov S, Hjortkjaer J, Dau T, Corfas G, Liberman LD, Liberman MC. Hear Res, 2025 Feb; 456: 109172 DOI:10.1016/j.heares.2024.109172
      PMID: PMC11772111
    • Journal Article
      Imaging poly(ADP-ribose) polymerase-1 (PARP1) in vivo with 18F-labeled brain penetrant positron emission tomography (PET) ligand
      Zhou X, Chen J, Patel JS, Ran W, Li Y, Van RS, Ibrahim MMH, Zhao C, Gao Y, Rong J, Chaudhary AF, Li G, Hu J, Davenport AT, Daunais JB, Shao Y, Ran C, Collier TL, Haider A, Schuster DM, Levey AI, Wang L, Corfas G, Liang SH. Acta Pharmaceutica Sinica B, 2025 Jan 1; DOI:10.1016/j.apsb.2025.05.020
    • Journal Article
      A modiolar-pillar gradient in auditory-nerve dendritic length: a novel post-synaptic contribution to dynamic range?
      Kostrikov S, Hjortkjaer J, Dau T, Corfas G, Liberman LD, Liberman MC. bioRxiv, 2024 Nov 4; DOI:10.1101/2024.11.04.621861
      PMID: PMC11580876
    • Presentation
      Hidden Hearing Loss: Cellular/Molecular Mechanisms; Implications for Auditory Processing, and Potential Therapies
      Corfas G. 2024 Nov 8;
    • Journal Article
      Hidden hearing loss in a Charcot-Marie-Tooth type 1A mouse model.
      Cassinotti LR, Ji L, Yuk MC, Desai AS, Cass ND, Amir ZA, Corfas G. JCI Insight, 2024 Oct 8; 9 (19): DOI:10.1172/jci.insight.180315
      PMID: PMC11466197
    • Preprint
      Population coding of auditory space in the dorsal inferior colliculus persists with altered binaural cues.
      Rogalla MM, Quass GL, Yardley H, Martinez-Voigt C, Ford AN, Wallace G, Dileepkumar D, Corfas G, Apostolides PF. 2024 Sep 13; DOI:10.1101/2024.09.13.612867
      PMID: 39314270
    • Preprint
      Hidden hearing loss in a Charcot-Marie-Tooth type 1A mouse model.
      Cassinotti LR, Ji L, Yuk MC, Desai AS, Cass ND, Amir ZA, Corfas G. 2024 Aug 15; DOI:10.1101/2023.12.14.571732
      PMID: 38168255
    Featured News & Stories ear in the mix of photos in the background of people faded out
    Health Lab
    Creating supranormal hearing in mice
    A study from Michigan's Kresge Hearing Research Institute produced supranormal hearing in mice, while also supporting a hypothesis on the cause of hidden hearing loss in people.