Chunling Chen
Assistant Research Scientist, Pharmacology
[email protected]

Available to mentor
Chunling Chen
Assistant Research Scientist
  • Recent Publications
    • Recent Publications See All Publications
    • Journal Article
      Antisense oligonucleotides restore excitability, GABA signalling and sodium current density in a Dravet syndrome model.
      Yuan Y, Lopez-Santiago L, Denomme N, Chen C, O'Malley HA, Hodges SL, Ji S, Han Z, Christiansen A, Isom LL. Brain, 2024 Apr 4; 147 (4): 1231 - 1246. DOI:10.1093/brain/awad349
      PMID: 37812817
    • Journal Article
      Epilepsy and sudden unexpected death in epilepsy in a mouse model of human SCN1B-linked developmental and epileptic encephalopathy.
      Chen C, Ziobro J, Robinson-Cooper L, Hodges SL, Chen Y, Edokobi N, Lopez-Santiago L, Habig K, Moore C, Minton J, Bramson S, Scheuing C, Daddo N, Štěrbová K, Weckhuysen S, Parent JM, Isom LL. Brain Commun, 2023 5 (6): fcad283 DOI:10.1093/braincomms/fcad283
      PMID: 38425576
    • Journal Article
      Excitatory and inhibitory neuron defects in a mouse model of Scn1b-linked EIEE52.
      Hull JM, O'Malley HA, Chen C, Yuan Y, Denomme N, Bouza AA, Anumonwo C, Lopez-Santiago LF, Isom LL. Ann Clin Transl Neurol, 2020 Nov; 7 (11): 2137 - 2149. DOI:10.1002/acn3.51205
      PMID: 32979291
    • Journal Article
      Antisense oligonucleotides increase Scn1a expression and reduce seizures and SUDEP incidence in a mouse model of Dravet syndrome.
      Han Z, Chen C, Christiansen A, Ji S, Lin Q, Anumonwo C, Liu C, Leiser SC, Meena , Aznarez I, Liau G, Isom LL. Sci Transl Med, 2020 Aug 26; 12 (558): DOI:10.1126/scitranslmed.aaz6100
      PMID: 32848094
    • Journal Article
      Scn1b deletion in adult mice results in seizures and SUDEP.
      O'Malley HA, Hull JM, Clawson BC, Chen C, Owens-Fiestan G, Jameson MB, Aton SJ, Parent JM, Isom LL. Ann Clin Transl Neurol, 2019 Jun; 6 (6): 1121 - 1126. DOI:10.1002/acn3.785
      PMID: 31211177
    • Journal Article
      Channelopathy as a SUDEP Biomarker in Dravet Syndrome Patient-Derived Cardiac Myocytes.
      Frasier CR, Zhang H, Offord J, Dang LT, Auerbach DS, Shi H, Chen C, Goldman AM, Eckhardt LL, Bezzerides VJ, Parent JM, Isom LL. Stem Cell Reports, 2018 Sep 11; 11 (3): 626 - 634. DOI:10.1016/j.stemcr.2018.07.012
      PMID: 30146492
    • Journal Article
      The adhesion function of the sodium channel beta subunit (β1) contributes to cardiac action potential propagation.
      Veeraraghavan R, Hoeker GS, Alvarez-Laviada A, Hoagland D, Wan X, King DR, Sanchez-Alonso J, Chen C, Jourdan J, Isom LL, Deschenes I, Smyth JW, Gorelik J, Poelzing S, Gourdie RG. Elife, 2018 Aug 14; 7: DOI:10.7554/eLife.37610
      PMID: 30106376
    • Journal Article
      Mapt deletion fails to rescue premature lethality in two models of sodium channel epilepsy.
      Chen C, Holth JK, Bunton-Stasyshyn R, Anumonwo CK, Meisler MH, Noebels JL, Isom LL. Ann Clin Transl Neurol, 2018 Aug; 5 (8): 982 - 987. DOI:10.1002/acn3.599
      PMID: 30128323