Nadejda Bozadjieva Kramer, PhD
Assistant Professor of Surgery
Department of Surgery
2800 Plymouth Rd, NCRC B25-3688
Ann Arbor, Michigan 48109
[email protected]

Available to mentor

Nadejda Bozadjieva Kramer, PhD
Assistant Professor
  • About
  • Links
  • Qualifications
  • Center Memberships
  • Research Overview
  • Recent Publications
  • About

    Dr. Bozadjieva Kramer’s research efforts leverage both basic and translational science towards a better understanding of the critical factors behind metabolic dysfunction. Her passion is to develop the best interventions to meet the enormous unmet needs of patients with obesity and metabolic disorders.

    Dr. Bozadjieva Kramer holds research appointments in the Ann Arbor Veterans Affairs Health Systems and Michigan Medicine, Department of Surgery. She has received several funding awards, including Department of Veterans Affairs Career Development Award, University of Michigan Center for Gastrointestinal Research Pilot Award, , Michigan Institute for Clinical & Health Research Fellowship award and Michigan Nutrition and Obesity Research Center Pilot Award..

    Links
    Qualifications
    • Postdoctoral Research Fellow
      University of Michigan, Surgery, 2022
    • PhD
      University of Michigan, Ann Arbor, 2016
    • MS
      University of Minnesota, Duluth, 2011
    • BS
      University of Minnesota, Duluth, 2009
    Center Memberships
    • Center Member
      Caswell Diabetes Institute
    Research Overview

    Dr. Bozadjieva Kramer's overall research interests focus on the pancreas-gut-liver axis, understanding the roles enterohepatic and nutrient signaling play in obesity, comorbidities (Type 2 diabetes, MASLD, and MASH) and how these change after rapid weight loss (diet, pharmacological, or surgery-induced weight loss). These projects employ extensive metabolic techniques including surgical, molecular, pharmacological, and physiological expertise in clinical and preclinical models.

    Recent Publications See All Publications
    • Preprint
      GDNF family receptor alpha-like (GFRAL) expression is restricted to the caudal brainstem
      Hes C, Gui L, Bay A, Alvarez F, Katz P, Paul T, Bozadjieva-Kramer N, Seeley RJ, Piccirillo CA, Sabatini P. bioRxiv, DOI:10.1101/2024.09.19.613956
    • Journal Article
      Gut-muscle communication links FGF19 levels to the loss of lean muscle mass following rapid weight loss.
      Wean J, Baranwal S, Miller N, Shin JH, O'Rourke RW, Burant CF, Seeley RJ, Rothberg AE, Bozadjieva-Kramer N. Diabetes Metab, 2024 Sep; 50 (5): 101570 DOI:10.1016/j.diabet.2024.101570
      PMID: 39134173
    • Journal Article
      Liraglutide Impacts Iron Homeostasis in a Murine Model of Hereditary Hemochromatosis.
      Bozadjieva-Kramer N, Shin JH, Blok NB, Jain C, Das NK, Polex-Wolf J, Knudsen LB, Shah YM, Seeley RJ. Endocrinology, 2024 Jul 26; 165 (9): DOI:10.1210/endocr/bqae090
      PMID: 39045670
    • Presentation
      The role of bile acids in the beneficial and deleterious effects of Sleeve gastrectomy
      Bozadjieva Kramer N. 2024 Jul 9;
    • Presentation
      The gut-liver communication during obesity and rapid weight loss
      Bozadjieva Kramer N. 2024 Jun 26;
    • Presentation
      The role of gut-liver communication after Vertical Sleeve Gastrectomy
      Bozadjieva Kramer N. 2024 Jun;
    • Presentation
      The role of the gut-liver axis in metabolism
      Bozadjieva Kramer N. 2024 Jun;
    • Preprint
      Control of Physiologic Glucose Homeostasis via the Hypothalamic Modulation of Gluconeogenic Substrate Availability.
      Hashsham A, Kodur N, Su J, Tomlinson AJ, Yacawych WT, Flak JN, Lewis KT, Oles LR, Mori H, Bozadjieva-Kramer N, Turcu AF, MacDougald OA, Myers MG, Affinati AH. 2024 May 21; DOI:10.1101/2024.05.20.594873
      PMID: 38826340
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