Research Assistant Professor
Internal Medicine
[email protected]
Available to mentor
Helmut Grasberger
Research Assistant Professor
1) Mucosal innate immunity
2) Function of NOX NADPH oxidases
3) Pathogenesis of inflammatory bowel disease
4) Redox regulation of microbiota
5) Genetic susceptibility factors
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Grasberger H, Dumitrescu AM, Liao X-H, Swanson EG, Weiss RE, Srichomkwun P, Pappa T, Chen J, Yoshimura T, Hoffmann P, França MM, Tagett R, Onigata K, Costagliola S, Ranchalis J, Vollger MR, Stergachis AB, Chong JX, Bamshad MJ, Smits G, Vassart G, Refetoff S. Nat Genet, 2024 May; 56 (5): 877 - 888.Journal ArticleSTR mutations on chromosome 15q cause thyrotropin resistance by activating a primate-specific enhancer of MIR7-2/MIR1179.
DOI:10.1038/s41588-024-01717-7 PMID: 38714869 -
Grasberger H, Magis AT, Sheng E, Conomos MP, Zhang M, Garzotto LS, Hou G, Bishu S, Nagao-Kitamoto H, El-Zaatari M, Kitamoto S, Kamada N, Stidham RW, Akiba Y, Kaunitz J, Haberman Y, Kugathasan S, Denson LA, Omenn GS, Kao JY. J Clin Invest, 2021 May 3; 131 (9):Journal ArticleDUOX2 variants associate with preclinical disturbances in microbiota-immune homeostasis and increased inflammatory bowel disease risk.
DOI:10.1172/JCI141676 PMID: 33651715 -
Grasberger H, Gao J, Nagao-Kitamoto H, Kitamoto S, Zhang M, Kamada N, Eaton KA, El-Zaatari M, Shreiner AB, Merchant JL, Owyang C, Kao JY. Gastroenterology, 2015 Dec; 149 (7): 1849 - 1859.Journal ArticleIncreased Expression of DUOX2 Is an Epithelial Response to Mucosal Dysbiosis Required for Immune Homeostasis in Mouse Intestine.
DOI:10.1053/j.gastro.2015.07.062 PMID: 26261005 -
Grasberger H, El-Zaatari M, Dang DT, Merchant JL. Gastroenterology, 2013 Nov; 145 (5): 1045 - 1054.Journal ArticleDual oxidases control release of hydrogen peroxide by the gastric epithelium to prevent Helicobacter felis infection and inflammation in mice.
DOI:10.1053/j.gastro.2013.07.011 PMID: 23860501 -
Grasberger H, De Deken X, Mayo OB, Raad H, Weiss M, Liao X-H, Refetoff S. Mol Endocrinol, 2012 Mar; 26 (3): 481 - 492.Journal ArticleMice deficient in dual oxidase maturation factors are severely hypothyroid.
DOI:10.1210/me.2011-1320 PMID: 22301785 -
Grasberger H. Mol Cell Endocrinol, 2010 Jun 30; 322 (1-2): 99 - 106.Journal ArticleDefects of thyroidal hydrogen peroxide generation in congenital hypothyroidism.
DOI:10.1016/j.mce.2010.01.029 PMID: 20122987 -
Grasberger H, Van Sande J, Hag-Dahood Mahameed A, Tenenbaum-Rakover Y, Refetoff S. J Clin Endocrinol Metab, 2007 Jul; 92 (7): 2816 - 2820.Journal ArticleA familial thyrotropin (TSH) receptor mutation provides in vivo evidence that the inositol phosphates/Ca2+ cascade mediates TSH action on thyroid hormone synthesis.
DOI:10.1210/jc.2007-0366 PMID: 17456567 -
Grasberger H, Refetoff S. J Biol Chem, 2006 Jul 7; 281 (27): 18269 - 18272.Journal ArticleIdentification of the maturation factor for dual oxidase. Evolution of an eukaryotic operon equivalent.
DOI:10.1074/jbc.C600095200 PMID: 16651268
