1301 Catherine Street
Ann Arbor, MI 48109
Available to mentor
Dr. Zhang has over 15 years of research experience in the field of cancer biology with specific emphasis on identifying novel molecular targets in pancreatic cancer and diffuse intrinsic pontine glioma (DIPG) that are important in the response to radiation and immune checkpoint inhibitors. He is involved with several translational therapeutic projects to optimize the use of agents targeting ATM, PARP, DNA-PK, and FBXW7. Dr. Zhang also has extensive experience in mechanism-based studies of DNA double-strand break repair pathways and protein post-translational modifications. His expertise in laser microirradiation was essential in establishing this platform in the Experimental Irradiation Shared Resource in the UMCCC.
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Postdoctoral Research FellowUniversity of Michigan, Ann Arbor, 2014
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Postdoctoral Research FellowWake Forest University, Winston-Salem, 2012
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Postdoctoral Research FellowPeking Union Medical College Hospital, Beijing, 2009
Diffused Intrinsic Pontine Glioma, Pancreatic Cancer, Radiotherapy and Immunotherapy, DNA Repair, DNA Damage Response, E3 Ubiquitin Ligase, Protein Post-translational Modification
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Zhang Q, Jiang L, Wang W, Huber AK, Valvo VM, Jungles KM, Holcomb EA, Pearson AN, The S, Wang Z, Parsels LA, Parsels JD, Wahl DR, Rao A, Sahai V, Lawrence TS, Green MD, Morgan MA. JCI Insight, 2024 Feb 20;Journal ArticlePotentiating the radiation-induced type I interferon anti-tumoral immune response by ATM inhibition in pancreatic cancer
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Valvo VM, Vitale E, Tigano M, Evans R, Morgan MA, Zhang Q. Front Oncol, 2024 14: 1424895Journal ArticleCorrigendum: Editorial: Targeting DNA damage response to enhance antitumor innate immunity in radiotherapy.
DOI:10.3389/fonc.2024.1424895 PMID: 38939331 -
Zhang Q, Jiang L, Wang W, Huber AK, Valvo VM, Jungles KM, Holcomb EA, Pearson AN, The S, Wang Z, Parsels LA, Parsels JD, Wahl DR, Rao A, Sahai V, Lawrence TS, Green MD, Morgan MA. JCI Insight, 2024 Feb 20; 9 (6):Journal ArticlePotentiating the radiation-induced type I interferon antitumoral immune response by ATM inhibition in pancreatic cancer.
DOI:10.1172/jci.insight.168824 PMID: 38376927 -
Zhang Q, Zou P, Zhu M, Sui D, Wang S, Hu Z, Wang Y, Jing L, Zheng J. Bioorg Med Chem Lett, 2023 Nov 15; 96: 129502Journal ArticleSynthesis and biological activity assay of novel camptothecin-peptidic conjugates based on PEPT1.
DOI:10.1016/j.bmcl.2023.129502 PMID: 37806498 -
Valvo V, Vitale E, Tigano M, Evans R, Morgan MA, Zhang Q. Frontiers in Oncology, 2023 Jul 25;Journal ArticleTargeting DNA damage response to enhance antitumor innate immunity in radiotherapy
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Parsels LA, Wahl DW, Koschmann C, Morgan MA, Zhang Q. Neoplasia, 2023 Mar 1;Journal ArticleDeveloping H3K27M mutant selective radiosensitization strategies in diffuse intrinsic pontine glioma
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Wang W, McMillan MT, Zhao X, Wang Z, Jiang L, Karnak D, Lima F, Parsels JD, Parsels LA, Lawrence TS, Frankel TL, Morgan MA, Green MD, Zhang Q. Mol Cancer Res, 2022 Jul 6; 20 (7): 1137 - 1150.Journal ArticleDNA-PK Inhibition and Radiation Promote Antitumoral Immunity through RNA Polymerase III in Pancreatic Cancer.
DOI:10.1158/1541-7786.MCR-21-0725 PMID: 35348737 -
Parsels LA, Zhang Q, Karnak D, Parsels JD, Lam K, Willers H, Green MD, Rehemtulla A, Lawrence TS, Morgan MA. Int J Radiat Oncol Biol Phys, 2021 Dec 1; 111 (5): e38 - e53.Journal ArticleTranslation of DNA Damage Response Inhibitors as Chemoradiation Sensitizers From the Laboratory to the Clinic.
DOI:10.1016/j.ijrobp.2021.07.1708 PMID: 34348175
