Associate Research Scientist
Internal Medicine
Internal Medicine
1600 Huron Parkway, B520, G351
Ann Arbor, Michigan 48109-1600
[email protected]
1600 Huron Parkway, B520, G351
Ann Arbor, Michigan 48109-1600
Available to mentor
Longchuan Bai
Associate Research Scientist
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Postdoc AssociateHoward Hughes Medical Institute, United States, 2000
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Bai L, Zhou H, Xu R, Zhao Y, Chinnaswamy K, McEachern D, Chen J, Yang C-Y, Liu Z, Wang M, Liu L, Jiang H, Wen B, Kumar P, Meagher JL, Sun D, Stuckey JA, Wang S. Cancer Cell, 2019 Nov 11; 36 (5): 498 - 511.e17.Journal ArticleA Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo.
DOI:10.1016/j.ccell.2019.10.002 PMID: 31715132 -
Xiang W, Yang C-Y, Bai L. Onco Targets Ther, 2018 11: 7301 - 7314.Journal ArticleMCL-1 inhibition in cancer treatment.
DOI:10.2147/OTT.S146228 PMID: 30425521 -
Bai L, Zhou B, Yang C-Y, Ji J, McEachern D, Przybranowski S, Jiang H, Hu J, Xu F, Zhao Y, Liu L, Fernandez-Salas E, Xu J, Dou Y, Wen B, Sun D, Meagher J, Stuckey J, Hayes DF, Li S, Ellis MJ, Wang S. Cancer Res, 2017 May 1; 77 (9): 2476 - 2487.Journal ArticleTargeted Degradation of BET Proteins in Triple-Negative Breast Cancer.
DOI:10.1158/0008-5472.CAN-16-2622 PMID: 28209615 -
Bai L, Smith DC, Wang S. Pharmacol Ther, 2014 Oct; 144 (1): 82 - 95.Journal ArticleSmall-molecule SMAC mimetics as new cancer therapeutics.
DOI:10.1016/j.pharmthera.2014.05.007 PMID: 24841289 -
Xu R, Zhou H, Bai L, McEachern D, Wu D, Acharyya RK, Wang M, Tošović J, Yang C-Y, Chinnaswamy K, Meagher JL, Stuckey JA, Liu C, Wang M, Wen B, Sun D, Wang S. J Med Chem, 2024 Nov 28; 67 (22): 20495 - 20513.Journal ArticleDiscovery of SD-436: A Potent, Highly Selective and Efficacious STAT3 PROTAC Degrader Capable of Achieving Complete and Long-Lasting Tumor Regression.
DOI:10.1021/acs.jmedchem.4c01946 PMID: 39509603 -
Acharyya RK, Rej RK, Hu B, Chen Z, Wu D, Lu J, Metwally H, McEachern D, Wang Y, Jiang W, Bai L, Tošović J, Gersch CL, Xu G, Zhang W, Wu W, Priestley ES, Sui Z, Sarkari F, Wen B, Sun D, Rae JM, Wang S. J Med Chem, 2024 Nov 14; 67 (21): 19010 - 19037.Journal ArticleDiscovery of ERD-1233 as a Potent and Orally Efficacious Estrogen Receptor PROTAC Degrader for the Treatment of ER+ Human Breast Cancer.
DOI:10.1021/acs.jmedchem.4c01521 PMID: 39485242 -
Krempski J, Yamani A, Thota LNR, Marella S, Ganesan V, Sharma A, Kaneshige A, Bai L, Zhou H, Foster PS, Wang S, Obi AT, Hogan SP. J Allergy Clin Immunol, 2024 Sep; 154 (3): 719 - 734.Journal ArticleIL-4-STAT6 axis amplifies histamine-induced vascular endothelial dysfunction and hypovolemic shock.
DOI:10.1016/j.jaci.2024.05.009 PMID: 38777155 -
Wang C, Wang M, Wang Y, Rej RK, Aguilar A, Xu T, Bai L, Tošović J, McEachern D, Li Q, Sarkari F, Wen B, Sun D, Wang S. J Med Chem, 2024 Aug 22; 67 (16): 14125 - 14154.Journal ArticleDiscovery of CW-3308 as a Potent, Selective, and Orally Efficacious PROTAC Degrader of BRD9.
DOI:10.1021/acs.jmedchem.4c00971 PMID: 39132814
