Mukesh K Nyati, PhD
Professor
Radiation Oncology
1600 Huron Parkway
Ann Arbor, MI 48109
[email protected]

Available to mentor

Mukesh K Nyati, PhD
Professor
  • About
  • Qualifications
  • Center Memberships
  • Research Overview
  • Recent Publications
  • About

    Dr. Nyati is a professor in the Department of Radiation Oncology at the University of Michigan, with over 30 years of expertise in basic and translational oncology. He is actively involved in academic education, research, and peer review for top-tier journals and funding agencies such as the NIH. An avid photographer and dedicated cancer awareness volunteer, his work is funded by agencies including the NIH and DoD. Dr. Nyati has obtained numerous international patents for his contributions to the development of novel anti-cancer agents and has been involved in several biotech startups.

    Qualifications
    • Post-Doctoral
      University of Michigan, Ann Arbor, 2001
    • Post-Doctoral
      Indian Institute of Science, Bangalore, 1998
    • PhD
      University of Rajasthan, Jaipur, 1996
    • Certificate
      University of Rajasthan, Jaipur, 1992
    • MS
      Government College Kota, University of Ajmer, Ajmer, 1991
    • BS
      Government College Jhalawar, University of Ajmer, Ajmer, 1989
    Center Memberships
    • Center Member
      Rogel Cancer Center
    Research Overview

    The main focus of Dr. Nyati's research is investigating the role of protein stability in cancer progression and treatment. He has been extensively studying key oncogenes such as EGFR, BRAF, and KRAS, aiming to develop agents that induce the selective degradation of activated EGFR. Additionally, he explores the functions of the EGFR protein that are independent of its kinase activity, particularly its role in cell survival. Dr. Nyati is also part of the Protein Folding Disease Initiative Group, where he investigates the roles of Hsp90 chaperone machinery in DNA repair. His comprehensive research continues to contribute significantly to the field of cancer research.

    Recent Publications See All Publications
    • Journal Article
      Investigating NanoLuc-EGFR engineered cell lines for real-time monitoring of EGFR protein dynamics in live cells.
      Mehta RK, Tan M, Hassan MK, Zhao T, Markovitz DM, Lawrence TS, Nyati MK. Biochem Biophys Res Commun, 2024 Nov 12; 733: 150711 DOI:10.1016/j.bbrc.2024.150711
      PMID: 39312880
    • Preprint
      A molecularly engineered lectin destroys EGFR and inhibits the growth of non-small cell lung cancer.
      Chan SM, Raglow Z, Pal A, Gitlin SD, Legendre M, Thomas D, Mehta RK, Tan M, Nyati MK, Rehemtulla A, Markovitz DM. 2024 Mar 20; DOI:10.1101/2024.03.18.585535
      PMID: 38562773
    • Presentation
      From Observation to Innovation: A Decade-Long Expedition in Targeting Activated EGFR for Cancer Therapy
      Nyati M. 2024 Jan 5;
    • Presentation
      Innovation in Research and Education
      2024 Jan 3;
    • Presentation
      Activated-EGFR Degradation: A Promising Approach for EGFR Positive Cancer
      Nyati M. 2023 Dec 27;
    • Presentation
      Discussion on Drug Target Engagement
      2023 Dec 26;
    • Presentation
      Protein Degradation-Based Targeting of EGFR in KRAS-Mutant Non-Small Cell Lung Cancer and Pancreatic Ductal Adenocarcinoma: Discovery of a Novel Small Molecule Degrader
      Nyati M. 2023 Sep 21;
    • Presentation
      Advancing EGFR targeting agent in mutant KRAS cancers
      Nyati M. 2023 Jun 29;