1600 Huron Parkway
Ann Arbor, MI 48109
Available to mentor
Dr. Nyati is a professor in the Department of Radiation Oncology at the University of Michigan, with over 30 years of expertise in basic and translational oncology. He is actively involved in academic education, research, and peer review for top-tier journals and funding agencies such as the NIH. An avid photographer and dedicated cancer awareness volunteer, his work is funded by agencies including the NIH and DoD. Dr. Nyati has obtained numerous international patents for his contributions to the development of novel anti-cancer agents and has been involved in several biotech startups.
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Post-DoctoralUniversity of Michigan, Ann Arbor, 2001
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Post-DoctoralIndian Institute of Science, Bangalore, 1998
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PhDUniversity of Rajasthan, Jaipur, 1996
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CertificateUniversity of Rajasthan, Jaipur, 1992
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MSGovernment College Kota, University of Ajmer, Ajmer, 1991
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BSGovernment College Jhalawar, University of Ajmer, Ajmer, 1989
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Center MemberRogel Cancer Center
The main focus of Dr. Nyati's research is investigating the role of protein stability in cancer progression and treatment. He has been extensively studying key oncogenes such as EGFR, BRAF, and KRAS, aiming to develop agents that induce the selective degradation of activated EGFR. Additionally, he explores the functions of the EGFR protein that are independent of its kinase activity, particularly its role in cell survival. Dr. Nyati is also part of the Protein Folding Disease Initiative Group, where he investigates the roles of Hsp90 chaperone machinery in DNA repair. His comprehensive research continues to contribute significantly to the field of cancer research.
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Mehta RK, Tan M, Hassan MK, Zhao T, Markovitz DM, Lawrence TS, Nyati MK. Biochem Biophys Res Commun, 2024 Nov 12; 733: 150711Journal ArticleInvestigating NanoLuc-EGFR engineered cell lines for real-time monitoring of EGFR protein dynamics in live cells.
DOI:10.1016/j.bbrc.2024.150711 PMID: 39312880 -
Chan SM, Raglow Z, Pal A, Gitlin SD, Legendre M, Thomas D, Mehta RK, Tan M, Nyati MK, Rehemtulla A, Markovitz DM. 2024 Mar 20;PreprintA molecularly engineered lectin destroys EGFR and inhibits the growth of non-small cell lung cancer.
DOI:10.1101/2024.03.18.585535 PMID: 38562773 -
Nyati M. 2024 Jan 5;PresentationFrom Observation to Innovation: A Decade-Long Expedition in Targeting Activated EGFR for Cancer Therapy
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2024 Jan 3;PresentationInnovation in Research and Education
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Nyati M. 2023 Dec 27;PresentationActivated-EGFR Degradation: A Promising Approach for EGFR Positive Cancer
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2023 Dec 26;PresentationDiscussion on Drug Target Engagement
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Nyati M. 2023 Sep 21;PresentationProtein Degradation-Based Targeting of EGFR in KRAS-Mutant Non-Small Cell Lung Cancer and Pancreatic Ductal Adenocarcinoma: Discovery of a Novel Small Molecule Degrader
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Nyati M. 2023 Jun 29;PresentationAdvancing EGFR targeting agent in mutant KRAS cancers