Denise O Leung, MD, MSc
Clinical Associate Professor of Neurology
[email protected]

Available to mentor
Denise O Leung, MD, MSc
Clinical Associate Professor
  • Qualifications
  • Center Memberships
  • Recent Publications
    • Qualifications
    • Neuro-Oncology Fellow
      Henry Ford Hospital, United States, 2014
    • Neurology Resident
      Henry Ford Hospital, Neurology, 2012
    • Transitional Year Resident
      Henry Ford Hospital, United States, 2009
    Center Memberships
    • Center Member
      Precision Health Initiative
    Recent Publications See All Publications
    • Journal Article
      CTNI-19. MYCOPHENOLATE MOFETIL TARGETS GLIOBLASTOMA DE-NOVO PURINE METABOLISM TO OVERCOME CHEMORADIATION RESISTANCE IN NEWLY DIAGNOSED AND RECURRENT GLIOBLASTOMA
      Umemura Y, Clarke N, Al-Holou W, Elaimy A, Scott A, Leung D, Kim M, Ferris S, Thomas J, Heth J, Schipper M, Suresh K, Lawrence T, Wahl D. Neuro-Oncology, 2024 Nov 11; 26 (Supplement_8): viii99 - viii100. DOI:10.1093/neuonc/noae165.0386
    • Journal Article
      P18.13.A DE-NOVO PURINE METABOLISM CAN BE TARGETED SAFELY IN GLIOBLASTOMA TREATMENT TO OVERCOME CHEMORADIATION RESISTANCE: AN INTERIM RESULT OF PHASE 0/1 CLINICAL TRIAL
      Umemura Y, Clarke N, Al-Holou W, Elaimy AL, Scott A, Leung D, Kim M, Ferris S, Thomas J, Heth J, Schipper M, Suresh K, Lawrence T, Wahl D. Neuro-Oncology, 2024 Oct 17; 26 (Supplement_5): v98 - v98. DOI:10.1093/neuonc/noae144.329
    • Journal Article
      AB036. Targeting glioblastoma de-novo purine metabolism to overcome chemoradiation resistance: an interim result of phase 0/1 clinical trial in newly diagnosed and recurrent glioblastoma.
      Umemura Y, Clarke N, Al-Holou W, Elaimy A, Scott A, Leung D, Kim M, Ferris S, Thomas J, Heth J, Schipper M, Suresh K, Lawrence T, Wahl D. Chin Clin Oncol, 2024 Aug; 13 (Suppl 1): AB036 DOI:10.21037/cco-24-ab036
      PMID: 39295354
    • Journal Article
      Practical guidance for direct oral anticoagulant use in the treatment of venous thromboembolism in primary and metastatic brain tumor patients.
      Ranjan S, Leung D, Ghiaseddin AP, Taylor JW, Lobbous M, Dhawan A, Budhu JA, Coffee E, Melnick K, Chowdhary SA, Lu-Emerson C, Kurz SC, Burke JE, Lam K, Patel MP, Dunbar EM, Mohile NA, Peters KB. Cancer, 2024 May 1; 130 (9): 1577 - 1589. DOI:10.1002/cncr.35220
      PMID: 38288941
    • Journal Article
      Metabolomic Profiles of Human Glioma Inform Patient Survival.
      Scott AJ, Correa LO, Edwards DM, Sun Y, Ravikumar V, Andren AC, Zhang L, Srinivasan S, Jairath N, Verbal K, Muraszko K, Sagher O, Carty SA, Hervey-Jumper S, Orringer D, Kim MM, Junck L, Umemura Y, Leung D, Venneti S, Camelo-Piragua S, Lawrence TS, Ippolito JE, Al-Holou WN, Chinnaiyan P, Heth J, Rao A, Lyssiotis CA, Wahl DR. Antioxid Redox Signal, 2023 Nov; 39 (13-15): 942 - 956. DOI:10.1089/ars.2022.0085
      PMID: 36852494
    • Journal Article
      Combined cytotoxic and immune-stimulatory gene therapy for primary adult high-grade glioma: a phase 1, first-in-human trial.
      Umemura Y, Orringer D, Junck L, Varela ML, West MEJ, Faisal SM, Comba A, Heth J, Sagher O, Leung D, Mammoser A, Hervey-Jumper S, Zamler D, Yadav VN, Dunn P, Al-Holou W, Hollon T, Kim MM, Wahl DR, Camelo-Piragua S, Lieberman AP, Venneti S, McKeever P, Lawrence T, Kurokawa R, Sagher K, Altshuler D, Zhao L, Muraszko K, Castro MG, Lowenstein PR. Lancet Oncol, 2023 Sep; 24 (9): 1042 - 1052. DOI:10.1016/S1470-2045(23)00347-9
      PMID: 37657463
    • Presentation
      Using APAS in speech research
      2023 Jun;
    • Journal Article
      A Call to Advocacy: The Role of The Neurologist and Neuro-oncologist (Op-Ed)
      Budhu J, Bhatia A, Burke J, Chowdhary S, Coffee E, Daras M, Dhawan A, Dunbar E, Ghiaseddin A, Kurz S, Lam K, Leeper H, Leung D, Lobbous M, Lu-Emerson C, Mohile N, Peters KB, Ranjan S, Sharma A, Taylor J. Neurology Blogs,