Associate Research Scientist
Internal Medicine
[email protected]
Available to mentor
Haibin Zhou
Associate Research Scientist
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Xu R, Zhou H, Bai L, McEachern D, Wu D, Acharyya RK, Wang M, Tošović J, Yang C-Y, Chinnaswamy K, Meagher JL, Stuckey JA, Liu C, Wang M, Wen B, Sun D, Wang S. J Med Chem, 2024 Nov 28; 67 (22): 20495 - 20513.Journal ArticleDiscovery of SD-436: A Potent, Highly Selective and Efficacious STAT3 PROTAC Degrader Capable of Achieving Complete and Long-Lasting Tumor Regression.
DOI:10.1021/acs.jmedchem.4c01946 PMID: 39509603 -
Sun J, Corradini S, Azab F, Shokeen M, Muz B, Miari KE, Maksimos M, Diedrich C, Asare O, Alhallak K, Park C, Lubben B, Chen Y, Adebayo O, Bash H, Kelley S, Fiala M, Bender DE, Zhou H, Wang S, Vij R, Williams MTS, Azab AK. Leukemia, 2024 Nov; 38 (11): 2355 - 2365.Journal ArticleIL-10R inhibition reprograms tumor-associated macrophages and reverses drug resistance in multiple myeloma.
DOI:10.1038/s41375-024-02391-8 PMID: 39215060 -
Krempski J, Yamani A, Thota LNR, Marella S, Ganesan V, Sharma A, Kaneshige A, Bai L, Zhou H, Foster PS, Wang S, Obi AT, Hogan SP. J Allergy Clin Immunol, 2024 Sep; 154 (3): 719 - 734.Journal ArticleIL-4-STAT6 axis amplifies histamine-induced vascular endothelial dysfunction and hypovolemic shock.
DOI:10.1016/j.jaci.2024.05.009 PMID: 38777155 -
Marella S, Sharma A, Ganesan V, Ferrer-Torres D, Krempski JW, Idelman G, Clark S, Nasiri Z, Vanoni S, Zeng C, Dlugosz AA, Zhou H, Wang S, Doyle AD, Wright BL, Spence JR, Chehade M, Hogan SP. J Allergy Clin Immunol, 2023 Dec; 152 (6): 1550 - 1568.Journal ArticleIL-13-induced STAT3-dependent signaling networks regulate esophageal epithelial proliferation in eosinophilic esophagitis.
DOI:10.1016/j.jaci.2023.07.021 PMID: 37652141 -
Wang S, Stuckey J.PatentSmall molecule degraders of stat3
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Zhou H, Lu J, Chinnaswamy K, Stuckey JA, Liu L, McEachern D, Yang C-Y, Bernard D, Shen H, Rui L, Sun Y, Wang S. Nat Commun, 2021 May 11; 12 (1): 2621Journal ArticleSelective inhibition of cullin 3 neddylation through covalent targeting DCN1 protects mice from acetaminophen-induced liver toxicity.
DOI:10.1038/s41467-021-22924-4 PMID: 33976147 -
Zhou H, Bai L, Xu R, McEachern D, Chinnaswamy K, Li R, Wen B, Wang M, Yang C-Y, Meagher JL, Sun D, Stuckey JA, Wang S. ACS Med Chem Lett, 2021 Jun 10; 12 (6): 996 - 1004.Journal ArticleSD-91 as A Potent and Selective STAT3 Degrader Capable of Achieving Complete and Long-Lasting Tumor Regression.
DOI:10.1021/acsmedchemlett.1c00155 PMID: 34141084 -
Zhou H, Bai L, Xu R, McEachern D, Chinnaswamy K, Li R, Wen B, Wang M, Yang CY, Liu Z, Wang M, Liu L, Meagher JL, Sun D, Stuckey JA, Wang S. ACS Med. Chem. Lett., 2021 May 10; 12 (6):Journal ArticleSD-91 as A Potent and Selective STAT3 Degrader Capable of Achieving Complete and Long-Lasting Tumor Regression
