1301 Catherine Street, Med Sci 1, RM 4311
Ann Arbor, MI 48109
Available to mentor
Dr. Ray has over 10 years of research experience in the field of cell and developmental biology. She obtained her PhD in 2007 from the Department of Biological Sciences at the University of Illinois at Chicago (UIC), where she studied the neurodevelopment of Caenorhabditis elegans. During her postdoctoral studies she became interested in cancer biology where she studied the role of chemokine receptors (CXCR4 and CXCR7) in breast cancer metastasis. As a Research Investigator in the Department of Radiation Oncology she studies factors that regulate the stability of various oncoproteins including Epidermal Growth Factor Receptor (EGFR) and mutant KRAS. She is also actively involved in collaborative research identifying ubiquitin ligases (E3s) responsible for regulating protein stabilities of various oncogenes including mutant TP53 and CYP24A1.
-
Postdoctoral Research AssociateNorthwestern University, Chicago, 2008
Factors regulating EGFR protein stability.
Oncogenic potential of CYP24A1 in lung cancer progression.
Understanding the role of GRAIL in Barrett’s progression to esophageal adenocarcinoma (EAC).
-
Ray P, Jaiswal S, Ferrer-Torres D, Wang Z, Nancarrow D, Curtin M, Martinho MS, Lacy SM, Kasturirangan S, Thomas D, Spence JR, Truttmann MC, Lagisetty KH, Lawrence TS, Wang TD, Beer DG, Ray D. Mol Cancer Res, 2024 Nov 1; 22 (11): 996 - 1010.Journal ArticleGRAIL1 Stabilizes Misfolded Mutant p53 through a Ubiquitin Ligase-Independent, Chaperone Regulatory Function.
DOI:10.1158/1541-7786.MCR-24-0361 PMID: 39018356 -
McEwen DP, Ray P, Nancarrow DJ, Wang Z, Kasturirangan S, Abdullah S, Balan A, Hoskeri R, Thomas D, Lawrence TS, Beer DG, Lagisetty KH, Ray D. JCI Insight, 2024 May 23; 9 (13):Journal ArticleISG15/GRAIL1/CD3 axis influences survival of patients with esophageal adenocarcinoma.
DOI:10.1172/jci.insight.179315 PMID: 38781019 -
Ray P. 2023 Mar 22;PresentationRadiosensitization of esophageal adenocarcinoma cells: importance of DNAJA1 and ISG15 targeting
-
Ray P. 2022 Aug 18;PresentationRNF128 Iso1 cooperates with mutant p53 in Barrett's progression
-
Tonaye H, David K, Ming T, Ralph J, Yi L, Philip B, Yilun S, Erin S, Ray P, Christopher M, Martha M, Matthew JS, Michael G, Shirish MG, Gregory AY, Muneesh T, Issam EN, Caitlin AS, Randall TH, Shruti J, Theodore SL, Dipankar R. Translational Oncology, 2022 Apr 11; 21:Journal ArticleImproved prediction of radiation pneumonitis by combining biological and radiobiological parameters using a data-driven Bayesian network analysis
-
Ray P, Nancarrow DJ, Ferrer-Torres D, Wang Z, San Martinho M, Hinton T, Wu JH, Wu A, Turgeon DK, Hammer MA, Dame MK, Lawrence TS, O'Brien PJ, Spence JR, Beer DG, Ray D. Cell Mol Gastroenterol Hepatol, 2022 13 (1): 129 - 149.Journal ArticleUBCH5 Family Members Differentially Impact Stabilization of Mutant p53 via RNF128 Iso1 During Barrett's Progression to Esophageal Adenocarcinoma.
DOI:10.1016/j.jcmgh.2021.08.003 PMID: 34416429 -
Ray P, Derek JN, Daysha F-T, Zhuwen W, May SM, Tonaye H, Joshua W, Angeline W, Danielle KT, Max AH, Michael KD, Theodore SL, Patrick JO, Jason RS, David GB, Dipankar R. Cellular and Molecular Gastroenterology and Hepatology, 2021 Aug 17; 13 (1): 129 - 149.Proceeding / Abstract / PosterUBCH5 Family Members Differentially Impact Stabilization of Mutant p53 via RNF128 Iso1 During Barrett's Progression to Esophageal Adenocarcinoma
DOI:10.1016/j.jcmgh.2021.08.003 -
Ray P. 2021 May 5;PresentationRNF128 Iso1-Mutant p53 Cooperation in Barrett's Progression
