Dongshan Yang
Research Assistant Professor
Internal Medicine
[email protected]

Available to mentor
Dongshan Yang
Research Assistant Professor
  • Center Memberships
  • Research Overview
  • Recent Publications
    • Center Memberships
    • Center Member
      MM-PKUHSC Joint Institute
    • Center Member
      Samuel and Jean Frankel Cardiovascular Center
    Research Overview

    One of the bottlenecks for developing novel therapies, including the cutting-edge gene therapy and gene editing therapies, is lack of appropriate animal models for translational studies. While mouse models excel in elucidating mechanisms, they have limitations in translational studies. The overall goal of Dr. Yang’s research is the modeling of human diseases using large animals and develop genome editing therapies using these animal models.

    Recent Publications See All Publications
    • Journal Article
      Selective nanosecond laser removal of retinal pigment epithelium for cell therapy.
      Nguyen VP, Karoukis AJ, Hu J, Wei Z, Yang D, Fahim AT, Wang X, Paulus YM. Sci Rep, 2024 Aug 21; 14 (1): 19457 DOI:10.1038/s41598-024-69917-z
      PMID: 39169055
    • Journal Article
      Multimodal Imaging-Guided Stem Cell Ocular Treatment.
      Nguyen VP, Karoukis AJ, Qian W, Chen L, Perera ND, Yang D, Zhang Q, Zhe J, Henry J, Liu B, Zhang W, Fahim AT, Wang X, Paulus YM. ACS Nano, 2024 Jun 11; 18 (23): 14893 - 14906. DOI:10.1021/acsnano.3c10632
      PMID: 38801653
    • Presentation
      Rabbit Models for Eye Diseases
      Yang D. 2024 Feb 3;
    • Journal Article
      Serine synthesis via reversed SHMT2 activity drives glycine depletion and acetaminophen hepatotoxicity in MASLD.
      Ghrayeb A, Finney AC, Agranovich B, Peled D, Anand SK, McKinney MP, Sarji M, Yang D, Weissman N, Drucker S, Fernandes SI, Fernández-García J, Mahan K, Abassi Z, Tan L, Lorenzi PL, Traylor J, Zhang J, Abramovich I, Chen YE, Rom O, Mor I, Gottlieb E. Cell Metab, 2024 Jan 2; 36 (1): 116 - 129.e7. DOI:10.1016/j.cmet.2023.12.013
      PMID: 38171331
    • Journal Article
      Sotagliflozin attenuates liver-associated disorders in cystic fibrosis rabbits.
      Liang X, Hou X, Bouhamdan M, Sun Y, Song Z, Rajagopalan C, Jiang H, Wei H-G, Song J, Yang D, Guo Y, Zhang Y, Mou H, Zhang J, Chen YE, Sun F, Jin J-P, Zhang K, Xu J. JCI Insight, 2024 Feb 15; 9 (6): DOI:10.1172/jci.insight.165826
      PMID: 38358827
    • Journal Article
      Multimodal photoacoustic microscopy, optical coherence tomography, and fluorescence imaging of USH2A knockout rabbits.
      Nguyen VP, Hu J, Zhe J, Chen EY, Yang D, Paulus YM. Sci Rep, 2023 Dec 12; 13 (1): 22071 DOI:10.1038/s41598-023-48872-1
      PMID: 38086867
    • Presentation
      Editing the Rabbit Genome for Translational Research
      Yang D. 2023 Nov 13;
    • Patent
      Invention:2024-186 USH2A and USH3A rabbits
      Yang D, Chen YE, Zhang J, Xu J.